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NEWS OF THE WEEK<br />

FINDINGS<br />

Sweaty Human Evolution,<br />

Through a Mouse Lens<br />

Mice are helping scientists learn about the<br />

evolution of some humans’ sweat glands.<br />

In 2007, computation<strong>al</strong> an<strong>al</strong>yses reve<strong>al</strong>ed<br />

that some Asians<br />

carry a particular<br />

version of a gene<br />

c<strong>al</strong>led EDAR. To<br />

learn the effects of<br />

that version, c<strong>al</strong>led<br />

370A, Harvard<br />

Medic<strong>al</strong> School’s<br />

Yana Kamberov<br />

and her colleagues<br />

developed a strain<br />

of mice that carried<br />

370A instead of the<br />

usu<strong>al</strong> EDAR gene.<br />

Those mice have<br />

thicker hair, more<br />

sweat glands (blue tubes in the mouse footpad,<br />

above), denser mammary glands, and<br />

sm<strong>al</strong>ler fat pads around those mammary<br />

glands, the researchers report this week in<br />

Cell. The team <strong>al</strong>so ev<strong>al</strong>uated sweat gland<br />

density in Han Chinese carrying one or<br />

two copies of 370A and found that those<br />

with two copies had more sweat glands.<br />

Random Sample<br />

“It’s one of the fi rst papers that clearly<br />

shows that a change that was important in<br />

recent human evolution can be modeled<br />

in the mouse,” says Wolfgang Enard, an<br />

evolutionary gen<strong>et</strong>icist at the Max Planck<br />

Institute for Evolutionary Anthropology<br />

in Leipzig, Germany. The an<strong>al</strong>ysis suggests<br />

370A arose in Centr<strong>al</strong> China 30,000<br />

years ago and may have been favored as<br />

an adaptation to the humid environment.<br />

http://scim.ag/sweatyev<br />

First Evidence of Life<br />

Under Antarctic Ice<br />

Researchers have gotten the fi rst glimpse<br />

of life lurking beneath Antarctic ice. Last<br />

month, a U.S. team drilled through 1000<br />

m<strong>et</strong>ers of ice to reach subglaci<strong>al</strong> Lake<br />

Whillans, part of a complex hydrologic<strong>al</strong><br />

system in West Antarctica—and on 7 February<br />

the team announced that they now<br />

have obtained the fi rst evidence of microbi<strong>al</strong><br />

life in a subglaci<strong>al</strong> Antarctic lake.<br />

Last month, a team of Russian scientists<br />

announced that they had successfully<br />

sampled another subglaci<strong>al</strong> lake located<br />

thousands of kilom<strong>et</strong>ers away on the East<br />

Antarctic Ice She<strong>et</strong>; what microbes might<br />

exist in those waters are still unknown.<br />

But the two systems are very different:<br />

Diamonds Are a Sperm’s Best Friend<br />

It’s hard out here for a sperm—even the p<strong>et</strong>ri dishes researchers use to store and culture the<br />

cells might actu<strong>al</strong>ly harm their delicate cargo. Researchers in Germany suspect that exposing<br />

your standard polystyrene p<strong>et</strong>ri dish to water can cause its surface to soften into a layer of toxic<br />

goo made of chemic<strong>al</strong>s c<strong>al</strong>led reactive oxygen species, or ROS. ROS have been wreaking havoc<br />

on sperm and egg cells during<br />

in vitro fertilization (IVF)<br />

procedures for decades, but<br />

until now, nobody thought to<br />

blame the p<strong>et</strong>ri dish.<br />

So the researchers, led<br />

by materi<strong>al</strong>s scientist Andrei<br />

Sommer of Ulm University in<br />

Germany, came up with a solution that could bring back the sparkle: Make a p<strong>et</strong>ri dish out of<br />

quartz, and then coat it with a nanolayer of diamond. About 20% more sperm survived for<br />

42 hours in diamond-coated p<strong>et</strong>ri dishes than in the polystyrene containers usu<strong>al</strong>ly used for<br />

IVF, the researchers report in the Online Proceedings Library of the Materi<strong>al</strong>s Research Soci<strong>et</strong>y.<br />

“It’s an interesting preliminary study,” says Pravin Rao, a urologist at Johns Hopkins’ James<br />

Buchanan Brady Urologic<strong>al</strong> Institute in B<strong>al</strong>timore, Maryland, who was not involved in the study.<br />

“The most important thing to see is wh<strong>et</strong>her [the diamond-coated dishes] would improve IVF<br />

success rates”—particularly in cases complicated by low sperm counts, he says. “If you just have<br />

10 sperm, it’s great if even one extra sperm survives.” http://scim.ag/diamsperm<br />

744 15 FEBRUARY 2013 VOL 339 SCIENCE www.sciencemag.org<br />

Published by AAAS<br />

View from the bottom of Lake Whillans.<br />

Unlike Lake Vostok, the Whillans system<br />

has been in periodic contact with surface<br />

waters, rather than isolated from the rest of<br />

the plan<strong>et</strong> for millions of years. The team,<br />

which is seeking clues not only to glaci<strong>al</strong><br />

microbiology but <strong>al</strong>so to ice she<strong>et</strong> dynamics<br />

and the impact of climate change on the<br />

continent, hopes the Lake Whillans microbi<strong>al</strong><br />

community can shed light on organisms<br />

that can exist in the extreme dark and<br />

cold, and how such microbes might affect<br />

the chemistry of the ice.<br />

Proto-RNA: Clues to Origin of Life<br />

Origin of life researchers have long thought<br />

that RNA, the molecular cousin of the DNA<br />

that encodes our genes, may have played a<br />

starring role in the initi<strong>al</strong> evolution of life<br />

from a soup of organic molecules.<br />

But there are problems with this “RNA<br />

World” hypothesis. For starters, in water,<br />

the four chemic<strong>al</strong> components of RNA,<br />

the nucleotides abbreviated A, G, C, and<br />

U, don’t spontaneously assemble to create<br />

sizable molecules. So it remains a mystery<br />

how the fi rst long gene-length chains of<br />

RNA would have ever taken shape in Earth’s<br />

ancient environment.<br />

Now, researchers led by Nicholas Hud, a<br />

chemist at the Georgia Institute of Technology<br />

in Atlanta, report in the Journ<strong>al</strong> of the<br />

American Chemic<strong>al</strong> Soci<strong>et</strong>y that they have<br />

created a pair of RNA-like molecules that<br />

can spontaneously assemble into genelength<br />

chains in water. Although it’s likely<br />

to be diffi cult to d<strong>et</strong>ermine wh<strong>et</strong>her these<br />

proto-RNAs or others like them were present<br />

at the dawn of life, the researchers are<br />

now working to see if the proto-RNAs can<br />

indeed faithfully encode information and<br />

evolve toward RNA. http://scim.ag/RNAlife<br />

This week, Science is reporting from the<br />

AAAS Annu<strong>al</strong> Me<strong>et</strong>ing in Boston. Visit<br />

http://scim.ag/aaas_2013 for full coverage.<br />

CREDITS (TOP TO BOTTOM): ALBERTO BEHAR/JPL/ASU (UNDERWATER CAMERA FUNDED BY NSF AND NASA); Y. G. KAMBEROV ET AL., CELL 152 (14 FEBRUARY 2013) © 2013 ELSEVIER INC.; ISTOCKPHOTO; COURTESY OF ANDREI P. SOMMER AT ULM UNIVERSITY, GERMANY<br />

on February 14, 2013<br />

www.sciencemag.org<br />

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