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NEWS OF THE WEEK<br />
FINDINGS<br />
Sweaty Human Evolution,<br />
Through a Mouse Lens<br />
Mice are helping scientists learn about the<br />
evolution of some humans’ sweat glands.<br />
In 2007, computation<strong>al</strong> an<strong>al</strong>yses reve<strong>al</strong>ed<br />
that some Asians<br />
carry a particular<br />
version of a gene<br />
c<strong>al</strong>led EDAR. To<br />
learn the effects of<br />
that version, c<strong>al</strong>led<br />
370A, Harvard<br />
Medic<strong>al</strong> School’s<br />
Yana Kamberov<br />
and her colleagues<br />
developed a strain<br />
of mice that carried<br />
370A instead of the<br />
usu<strong>al</strong> EDAR gene.<br />
Those mice have<br />
thicker hair, more<br />
sweat glands (blue tubes in the mouse footpad,<br />
above), denser mammary glands, and<br />
sm<strong>al</strong>ler fat pads around those mammary<br />
glands, the researchers report this week in<br />
Cell. The team <strong>al</strong>so ev<strong>al</strong>uated sweat gland<br />
density in Han Chinese carrying one or<br />
two copies of 370A and found that those<br />
with two copies had more sweat glands.<br />
Random Sample<br />
“It’s one of the fi rst papers that clearly<br />
shows that a change that was important in<br />
recent human evolution can be modeled<br />
in the mouse,” says Wolfgang Enard, an<br />
evolutionary gen<strong>et</strong>icist at the Max Planck<br />
Institute for Evolutionary Anthropology<br />
in Leipzig, Germany. The an<strong>al</strong>ysis suggests<br />
370A arose in Centr<strong>al</strong> China 30,000<br />
years ago and may have been favored as<br />
an adaptation to the humid environment.<br />
http://scim.ag/sweatyev<br />
First Evidence of Life<br />
Under Antarctic Ice<br />
Researchers have gotten the fi rst glimpse<br />
of life lurking beneath Antarctic ice. Last<br />
month, a U.S. team drilled through 1000<br />
m<strong>et</strong>ers of ice to reach subglaci<strong>al</strong> Lake<br />
Whillans, part of a complex hydrologic<strong>al</strong><br />
system in West Antarctica—and on 7 February<br />
the team announced that they now<br />
have obtained the fi rst evidence of microbi<strong>al</strong><br />
life in a subglaci<strong>al</strong> Antarctic lake.<br />
Last month, a team of Russian scientists<br />
announced that they had successfully<br />
sampled another subglaci<strong>al</strong> lake located<br />
thousands of kilom<strong>et</strong>ers away on the East<br />
Antarctic Ice She<strong>et</strong>; what microbes might<br />
exist in those waters are still unknown.<br />
But the two systems are very different:<br />
Diamonds Are a Sperm’s Best Friend<br />
It’s hard out here for a sperm—even the p<strong>et</strong>ri dishes researchers use to store and culture the<br />
cells might actu<strong>al</strong>ly harm their delicate cargo. Researchers in Germany suspect that exposing<br />
your standard polystyrene p<strong>et</strong>ri dish to water can cause its surface to soften into a layer of toxic<br />
goo made of chemic<strong>al</strong>s c<strong>al</strong>led reactive oxygen species, or ROS. ROS have been wreaking havoc<br />
on sperm and egg cells during<br />
in vitro fertilization (IVF)<br />
procedures for decades, but<br />
until now, nobody thought to<br />
blame the p<strong>et</strong>ri dish.<br />
So the researchers, led<br />
by materi<strong>al</strong>s scientist Andrei<br />
Sommer of Ulm University in<br />
Germany, came up with a solution that could bring back the sparkle: Make a p<strong>et</strong>ri dish out of<br />
quartz, and then coat it with a nanolayer of diamond. About 20% more sperm survived for<br />
42 hours in diamond-coated p<strong>et</strong>ri dishes than in the polystyrene containers usu<strong>al</strong>ly used for<br />
IVF, the researchers report in the Online Proceedings Library of the Materi<strong>al</strong>s Research Soci<strong>et</strong>y.<br />
“It’s an interesting preliminary study,” says Pravin Rao, a urologist at Johns Hopkins’ James<br />
Buchanan Brady Urologic<strong>al</strong> Institute in B<strong>al</strong>timore, Maryland, who was not involved in the study.<br />
“The most important thing to see is wh<strong>et</strong>her [the diamond-coated dishes] would improve IVF<br />
success rates”—particularly in cases complicated by low sperm counts, he says. “If you just have<br />
10 sperm, it’s great if even one extra sperm survives.” http://scim.ag/diamsperm<br />
744 15 FEBRUARY 2013 VOL 339 SCIENCE www.sciencemag.org<br />
Published by AAAS<br />
View from the bottom of Lake Whillans.<br />
Unlike Lake Vostok, the Whillans system<br />
has been in periodic contact with surface<br />
waters, rather than isolated from the rest of<br />
the plan<strong>et</strong> for millions of years. The team,<br />
which is seeking clues not only to glaci<strong>al</strong><br />
microbiology but <strong>al</strong>so to ice she<strong>et</strong> dynamics<br />
and the impact of climate change on the<br />
continent, hopes the Lake Whillans microbi<strong>al</strong><br />
community can shed light on organisms<br />
that can exist in the extreme dark and<br />
cold, and how such microbes might affect<br />
the chemistry of the ice.<br />
Proto-RNA: Clues to Origin of Life<br />
Origin of life researchers have long thought<br />
that RNA, the molecular cousin of the DNA<br />
that encodes our genes, may have played a<br />
starring role in the initi<strong>al</strong> evolution of life<br />
from a soup of organic molecules.<br />
But there are problems with this “RNA<br />
World” hypothesis. For starters, in water,<br />
the four chemic<strong>al</strong> components of RNA,<br />
the nucleotides abbreviated A, G, C, and<br />
U, don’t spontaneously assemble to create<br />
sizable molecules. So it remains a mystery<br />
how the fi rst long gene-length chains of<br />
RNA would have ever taken shape in Earth’s<br />
ancient environment.<br />
Now, researchers led by Nicholas Hud, a<br />
chemist at the Georgia Institute of Technology<br />
in Atlanta, report in the Journ<strong>al</strong> of the<br />
American Chemic<strong>al</strong> Soci<strong>et</strong>y that they have<br />
created a pair of RNA-like molecules that<br />
can spontaneously assemble into genelength<br />
chains in water. Although it’s likely<br />
to be diffi cult to d<strong>et</strong>ermine wh<strong>et</strong>her these<br />
proto-RNAs or others like them were present<br />
at the dawn of life, the researchers are<br />
now working to see if the proto-RNAs can<br />
indeed faithfully encode information and<br />
evolve toward RNA. http://scim.ag/RNAlife<br />
This week, Science is reporting from the<br />
AAAS Annu<strong>al</strong> Me<strong>et</strong>ing in Boston. Visit<br />
http://scim.ag/aaas_2013 for full coverage.<br />
CREDITS (TOP TO BOTTOM): ALBERTO BEHAR/JPL/ASU (UNDERWATER CAMERA FUNDED BY NSF AND NASA); Y. G. KAMBEROV ET AL., CELL 152 (14 FEBRUARY 2013) © 2013 ELSEVIER INC.; ISTOCKPHOTO; COURTESY OF ANDREI P. SOMMER AT ULM UNIVERSITY, GERMANY<br />
on February 14, 2013<br />
www.sciencemag.org<br />
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