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Programme Leader Starting salary will be in the range of £44,314 - £99,999 The MRC Toxicology Unit is an internationally renowned institution delivering field-changing mechanistic insights into toxicology and disease. Using an unbiased systems approach the Unit pursues an integrated scientific programme to examine the effects that occur following cellular exposure to chemicals, radiation and external biological agents.This research impacts directly on human health, with implications for reducing adverse drug reactions, drug attrition and bringing new insights leading to novel treatments for disease.The Unit has state of the art facilities with broad expertise in imaging, proteomics, genomics and deep sequencing. Applicants will be highly motivated with an outstanding international research profile, a substantial record of high impact publications, a proven ability to attract research funding and experience in leading a research team. A proven track record of international excellence with a background in DNA damage, epigenetics or neural biology is required in order to develop and lead an independent programme of research within either of these areas that are pertinent to an understanding of fundamental toxicology. The successful applicant will advance the discipline within the Unit and enhance its reputation both within the UK and internationally, provide leadership, demonstrate innovation and strategic vision in order to deliver a world-leading research agenda. In addition a contribution to the strategic management of the Unit and the successful implementation of its longer term vision for the Quinquennial Review (QQR) is expected. This is a tenured appointment with core funding including a number of research posts. Informal enquiries can be made to Professor Anne Willis, Unit Director at: aew5@le.ac.uk Applications should include a covering letter and full CV, an outline of current research interests (1 page) and a proposal for future research (up to 2 pages) together with the names and addresses of three professional referees who can be contacted prior to interview. Applications are handled by the RCUK Shared Services Centre, to apply please visit our job board at: http://www.topcareer.jobs/ entering job reference IRC82929 Further information about the Toxicology Unit can be found at: http://www.mrctox.le.ac.uk/ Closing date: 28th March 2013 The MRC is an Equal Opportunities Employer THE FACULTY OF BIOLOGY AND MEDICINE OF THE UNIVERSITY OF LAUSANNE, SWITZERLAND INVITES APPLICATIONS FOR THE FOLLOWING POSITION: FULL PROFESSOR DIRECTOR OF THE DEPARTMENT OF FUNDAMENTAL NEUROSCIENCE The Department of Fundamental Neuroscience at the University of Lausanne (http://www.unil.ch/dbcm) has been inaugurated recently. It intends to strengthen its research programme and developanewresearchfocusinmolecularandcell-biological aspects of neuroscience. We therefore seek an outstanding researcher (PhD, MD or MD/PhD) as full professor and new directoroftheDepartment.Thepositionrequiresarecord of scientific excellence and management experience, as well as vision and the motivation to lead and shape a Department. The future Director of the Department is expected to lead a strong, internationally competitive research programme, attract external funding and promote an interactive and synergistic research environment. She/he is expected to provide leadership in order to develop the Department of Fundamental Neuroscience into a centre of excellence in molecular and cell-biological aspects of neuroscience. The Department is embedded in a highly active and expanding research community in the Lake Geneva area, offering interactions with strong neurobiology programmes at the Federal Institute of Technology (EPFL) and the University Hospital (CHUV) in Lausanne, as well as at the University of Geneva. It also forms part of a programme of excellence in research by the Swiss National Science Foundation (NCCR Synapsy). Future deve- lopments in the Department will benefit from an excellent infrastructure in a new building on the main campus of the University. Further information may be obtained from Prof. Tafti (Mehdi.Tafti@unil.ch), chair of the search committee. The applications, in English, will include the curriculum vitae, thelistofpublicationsinwhichthefivemostsignificantones areidentified,asummaryofthemajordiscoveries(
AAAS is here – promoting universal science literacy. In 1985, AAAS founded Project 2061 with the goal of helping all Americans become literate in science, mathematics, and technology. Withits landmarkpublications Science for All Americans and Benchmarks for Science Literacy,Project 2061 set out recommendations forwhat all students should know andbe able to do in science, mathematics,and technology bythe time they graduatefrom high school. Today, many of the state standards in the UnitedStates have drawn their content from Project 2061. Every day Project 2061 staff use their expertise asteachers, researchers,and scientists toevaluate textbooks andassessments, create conceptual strand maps for educators, produce groundbreaking research and innovative books, CD-ROMs, and professional developmentworkshops for educators,all in the service of achieving our goal of universal science literacy. As a AAAS member, your dues help support Project 2061 as it works to improve science education. If you are not yet a AAAS member, join us. Togetherwe canmake adifference. To learn more, visit aaas.org/plusyou/project2061
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CONTENTS EDITORIAL 737 Designing Sc
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736 EDITED BY STELLA HURTLEY The Bu
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CREDITS: (TOP LEFT) TOM KOCHEL; (RI
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CREDIT: WIKIMEDIA COMMONS and orbit
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CREDITS (TOP TO BOTTOM): EOS/UNIVER
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CREDIT: P. CARRIL/ESA European NEWS
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CREDIT: TITUS ET AL., SCIENCE TRANS
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CREDITS (TOP TO BOTTOM): ISTOCKPHOT
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CREDIT: NATIONAL SCIENCE FOUNDATION
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CREDITS (CLOCKWISE FROM TOP LEFT):
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Sensing cytosolic danger ture capit
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TECHNICAL COMMENT 757-c Fig. 2. Rel
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TECHNICAL COMMENT 757-d values ment
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policy ideas” could be rectifi ed
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ARMS CONTROL Beyond Arms-Control Mo
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CREDIT: K. SUTLIFF/SCIENCE IMMUNOLO
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A Field et al. B Partial modern tre
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depend on the binding strength of t
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CREDIT: K. SUTLIFF/SCIENCE A Restri
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increasing the accuracy of the meas
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Structural Biological Materials: Cr
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shown in Fig. 1C, illustrate an ene
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increasing toughness. These methods
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experimental work has been conducte
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There are no other known achondrite
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δD (‰ V-SMOW) 400 300 200 100 0
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We estimated that we achieved a ran
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L929 cell lines stably expressing t
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Fig. 6. cGAS binds to DNA in the cy
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k1 and k2 (byconservationofenergyan
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How do we answer this trilemma? As
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(9). For n = 3, where we used three
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Fig. 2. Schematic and characterizat
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computation in the presence of erro
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REPORTS greatly eases the requireme
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dynamically, therefore, Sr3Ru2O7 ca
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16. N. P. Ong, Phys. Rev. B 43, 193
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low-energy break in IC 443 and 21s
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32. T. Kamae, N. Karlsson, T. Mizun
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ferent structures rather than the e
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Fig. 1. Fish behavioral response to
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charge distribution, and DNA bindin
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ecause the efficiency of transcript
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precision and efficiency. To invest
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4. A. J. Wood et al., Science 333,
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Page 108 and 109: visit the frontiers of science. . .
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Page 136 and 137: CREDIT: (© ISTOCKPHOTO.COM/NANTELA
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