AAAS is here – helping scientists achieve career success. Every month, over 400,000 students and scientists visit ScienceCareers.org in search of the information, advice, and opportunities they need to take the next step in their careers. A compl<strong>et</strong>e career resource, free to the public, Science Careers offers a suite of tools and services developed specific<strong>al</strong>ly for scientists. With hundreds of career development articles, webinars and downloadable bookl<strong>et</strong>s filled with practic<strong>al</strong> advice, a community forum providing answers to career questions, and thousands of job listings in academia, government, and industry, Science Careers has helped countless individu<strong>al</strong>s prepare themselves for successful careers. As a AAAS member, your dues help AAAS make this service freely available to the scientific community. If you’re not a member, join us. Tog<strong>et</strong>her we can make a difference. To learn more, visit aaas.org/plusyou/sciencecareers
online @sciencecareers.org POSITIONS OPEN AGROECOSYSTEM ECOLOGIST ASSISTANT PROFESSOR The University of Nebraska-Lincoln (UNL) Institute of Agriculture and Natur<strong>al</strong> Resources is inviting applications for a 12-month, tenure-leading Assistant Professor position with research and extension responsibilities in the Department of Entomology located at the University of Nebraska West Centr<strong>al</strong> Research and Extension Center in North Platte, Nebraska. Programming should address statewide resistance management issues and cropping systems work and contribute to Entomology efforts in managing arthropods and stress biology. A Ph.D. degree or equiv<strong>al</strong>ent in entomology or related field is required. Degree must be compl<strong>et</strong>ed before employment begins. To view the compl<strong>et</strong>e position d<strong>et</strong>ails and make applicationforthisposition,gototheUNLEmployment website: http://employment.unl.edu. Search for requisition number F_130050. Compl<strong>et</strong>e the faculty academic administrative information form. Attach a l<strong>et</strong>ter of interest, curriculum vitae, and a person<strong>al</strong> statement describing your research and extension interests and experience. Candidates should <strong>al</strong>so arrange for three l<strong>et</strong>ters of reference to be submitted to e-mail: mweidner1@unl.edu. Review of applications will begin on March 15, 2013, and continue until the position is filled or the search is closed. The University of Nebraska has an active Nation<strong>al</strong> Science Foundation ADVANCE gender equity program, and is committed to a plur<strong>al</strong>istic campus community through Affirmative Action/Equ<strong>al</strong> Opportunity, work-life b<strong>al</strong>ance, and du<strong>al</strong> careers. OKLAHOMA STATE UNIVERSITY Stillwater, OK ASSISTANT PROFESSOR, Anim<strong>al</strong> Physiologist, Tenure-track. The Department of Zoology at Oklahoma State University (OSU, website: http://zoology.okstate. edu) is searching for a physiologist working within the context of behavior, ecology, environment<strong>al</strong> stress, or evolution. Examples of research focus could include aging, development<strong>al</strong> biology, endocrinology, m<strong>et</strong>abolic physiology, and neurophysiology. Applicants should have a Ph.D., postdoctor<strong>al</strong> experience, teaching experience, and success in obtaining extramur<strong>al</strong> funding. Responsibilities include establishing an extramur<strong>al</strong>ly funded research program, mentoring M.S. and Ph.D. students, and teaching at the undergraduate and graduate levels. To apply please (1) send a single PDF file composed of a cover l<strong>et</strong>ter, curriculum vitae, and statements of research interests and teaching philosophy, and (2) have three l<strong>et</strong>ters of recommendation sent to the search committee chair, Dr. Puni Jeyasingh, at e-mail: zoologysearch@okstate.edu. Application review will begin March 29, 2013, with employment beginning August 15, 2013. Filling of this position is contingent upon availability of funding. Oklahoma State University is an Affirmative Action/Equ<strong>al</strong> Employment Opportunity/E:Verify Employer committed to diversity. OSU-Stillwater is a tobacco-free campus. FACULTY POSITIONS in Human Sociogenomics College of Liber<strong>al</strong> Arts and Sciences and Institute for Genomic Biology University of Illinois at Urbana-Champaign The University of Illinois, Urbana-Champaign, seeks candidates who examine the interdependence of biology and soci<strong>al</strong> behavior, with a particular interest in human sociogenomics for full-time faculty positions. Scholars in various soci<strong>al</strong> science fields whose research agenda engages the biologic<strong>al</strong> sciences as well as scholars in the biologic<strong>al</strong> sciences whose research lies at the interface with the soci<strong>al</strong> sciences are invited to apply. For compl<strong>et</strong>e d<strong>et</strong>ails see website: http://www. humansociogenomics.illinois.edu/. Illinois is an Affirmative Action/Equ<strong>al</strong> Opportunity Employer (website: http://www.inclusiveillinois.illinois.edu). 870 POSITIONS OPEN PLANT ARTHROPOD INTERACTIONS ASSISTANT PROFESSOR The Department of Entomology at the University of Nebraska-Lincoln (UNL) Institute of Agriculture and Natur<strong>al</strong> Resources is seeking applicants for the tenureleading position of Plant Arthropod Interactions at the Assistant Professor rank with a focus on the molecular biology of plant defense to arthropods and in teaching. A joint appointment with another department such as Biochemistry is possible. Approaches could include molecular biology, plant physiology, function<strong>al</strong> genomics, or the an<strong>al</strong>ysis of large data s<strong>et</strong>s. A Ph.D. degree or equiv<strong>al</strong>ent in entomology or related field (degree must be compl<strong>et</strong>ed before employment begins) with emphasis in molecular biology and research experience in arthropod interactions with plants. To view the compl<strong>et</strong>e position d<strong>et</strong>ails and make application for this position, go to the UNL Employment website: http://employment.unl.edu. Search for requisition number F_130049. Compl<strong>et</strong>e the faculty academic administrative information form. Attach a l<strong>et</strong>ter of interest, curriculum vitae, and a person<strong>al</strong> statement describing your research and teaching interests and experience. Candidates should <strong>al</strong>so arrange for three l<strong>et</strong>ters of reference to be submitted to e-mail: mweidner1@ unl.edu. Review of applications will begin on March 15, 2013, and continue until the position is filled or the search is closed. The University of Nebraska has an active Nation<strong>al</strong> Science Foundation ADVANCE gender equity program, and is committed to a plur<strong>al</strong>istic campus community through Affirmative Action/Equ<strong>al</strong> Opportunity, work-life b<strong>al</strong>ance, and du<strong>al</strong> careers. VICE PRESIDENT FOR RESEARCH Colorado State University (CSU), a Carnegie Research University (Very High Research Activity) in Fort Collins, Colorado, seeks an experienced, innovative research strategist to serve as Vice President for Research (VPR). CSU is one of the nation_s premier land-grant universities, with current annu<strong>al</strong> research expenditures in excess of $340 million and ranked 6th in feder<strong>al</strong>ly funded expenditures among universities without medic<strong>al</strong> schools in 2011. This position c<strong>al</strong>ls for an energ<strong>et</strong>ic, visionary individu<strong>al</strong>, a creator of bold solutions s<strong>et</strong>ting the foundation<strong>al</strong> environment for research and creative activities. The successful candidate must be a distinguished investigator/scholar with a demonstrated record of innovation in leadership and management at increasing levels of responsibility within academe and/or at the intersection of academic inquiry with private and government<strong>al</strong> sectors. Applications will be accepted until the position is filled; however, to be guaranteed full consideration, applications must be received by March 20, 2013, and include a single PDF document with the following information: (1) a l<strong>et</strong>ter of application stating applicant_s qu<strong>al</strong>ifications, (2) a statement of vision and philosophy for this position, (3) curriculum vitae, and (4) names and contact information of three individu<strong>al</strong>s who can comment on the applicant_s abilities to assume this leadership role. The application should be uploaded as a single PDF at the following website: http://cns.natsci. colostate.edu/employment/VPResearch/. A d<strong>et</strong>ailed description of this position can be accessed at, website: http://www.provost.colostate.edu. CSU is an Equ<strong>al</strong> Opportunity/Equ<strong>al</strong> Access/Affirmative Action Employer. Colorado State University conducts background checks on <strong>al</strong>l fin<strong>al</strong> candidates. 15 FEBRUARY 2013 VOL 339 SCIENCE www.sciencecareers.org POSITIONS OPEN VISITING ASSISTANT PROFESSOR BIOLOGY The Biology Department at Denison University, a selective liber<strong>al</strong> arts college, invites applications for a one-year visiting ASSISTANT PROFESSOR position with emphasis in ecology, evolution, and organism<strong>al</strong> biology to begin August 2013. Teaching load for this position is two courses with laboratories each semester; <strong>al</strong>l courses have enrollments of 24 or less. Anticipated teaching responsibilities include an upper-level majors course in organism<strong>al</strong> diversity/biology (such as plant diversity, ornithology, mycology), a sophomore-level majors course in Ecology and Evolution (BIOL 202), and the potenti<strong>al</strong> to teach a introductory majors or nonmajors course (visit website: http://www.denison. edu/biology/ for a d<strong>et</strong>ailed description of the department and its curriculum). Demonstrated ability in undergraduate teaching is expected and a Ph.D. is preferred (ABD acceptable). Please submit electronic application materi<strong>al</strong>s (a cover l<strong>et</strong>ter clearly indicating ability to teach an organism<strong>al</strong> biology course, Ecology & Evolution, and other teaching interests; curriculum vitae; statement of teaching philosophy; undergraduate and graduate transcripts; and three l<strong>et</strong>ters of recommendation) online at website: https://employment.denison.edu. Review of applications will begin February 26, 2013 and continue until the position is filled. Denison University is an Affirmative Action/Equ<strong>al</strong> Opportunity Employer. To achieve our mission as a liber<strong>al</strong> arts college, we continu<strong>al</strong>ly strive to foster a diverse campus community, which recognizes the v<strong>al</strong>ue of <strong>al</strong>l persons regardless of religion, race, <strong>et</strong>hnicity, gender, sexu<strong>al</strong> orientation, disability, or socio-economic background. ASSISTANT PROFESSOR – SOLID EARTH Massachus<strong>et</strong>ts Institute of Technology (MIT) The Department of Earth, Atmospheric and Plan<strong>et</strong>ary Sciences at MIT seeks applications for multiple faculty positions in the broad fields of geology, geobiology, geochemistry, and geophysics, including but not limited to earth history, tectonics, earthquake source physics, surface processes, sedimentology, environment<strong>al</strong> science, deep earth properties and processes, and rock physics. Applicants who integrate across tradition<strong>al</strong> boundaries are particularly encouraged to apply. The intention is to hire at the assistant professor level but more senior appointments can be considered. Applicants should submit curriculum vitae, one- to two-page descriptions of research and teaching plans, and the names, e-mail addresses, and telephone numbers of three profession<strong>al</strong> referees. Applicants should not ask their references to upload l<strong>et</strong>ters at the time of application; l<strong>et</strong>ters will be requested directly by MIT. Questions may be addressed to Professor Samuel Bowring, Search Committee Chair, at e-mail: sbowring@mit.edu. Applications are being accepted at Academic Jobs Online (website: https://academicjobsonline.org/ajo). To receive consideration, a compl<strong>et</strong>e application must be received by May 31, 2013. Search Contact: Mr. Michael Richard, Human Resources Administrator, EAPS, 54-912, Massachus<strong>et</strong>ts Institute of Technology, 77 Massachus<strong>et</strong>ts Avenue, Cambridge, MA 02139-4307; e-mail: mjr@mit.edu; telephone: 617-253-5184; fax: 617-253-8298. MIT is an Equ<strong>al</strong> Opportunity/Affirmative Action Employer; applications from women and underrepresented minority candidates are encouraged. MIT is a nonsmoking environment. POSTDOCTORAL POSITIONS Postdoctor<strong>al</strong> positions are immediately available for the study of biomembranes and membrane-associated proteins. Our interdisciplinary research includes quantitative imaging of cellular lipids and genomic-sc<strong>al</strong>e an<strong>al</strong>yis of membrane binding proteins with diverse cellular activities. This research group provides a highly ch<strong>al</strong>lenging and supportive environment with state-ofthe-art imaging and biophysic<strong>al</strong> facilities. Motivated candidates with a strong background in cell biology, chemic<strong>al</strong> biology, and microscopy are encouraged to apply. Please send curriculum vitae and names of three references to: Wonhwa Cho, Department of Chemistry (M/C 111), University of Illinois at Chicago, 845 W. Taylor Stre<strong>et</strong> Chicago, IL 60607. E-mail: wcho@ uic.edu. Website: http://brahms.chem.uic.edu.
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CONTENTS EDITORIAL 737 Designing Sc
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736 EDITED BY STELLA HURTLEY The Bu
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Sensing cytosolic danger ture capit
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TECHNICAL COMMENT 757-c Fig. 2. Rel
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policy ideas” could be rectifi ed
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ARMS CONTROL Beyond Arms-Control Mo
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A Field et al. B Partial modern tre
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depend on the binding strength of t
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increasing the accuracy of the meas
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Structural Biological Materials: Cr
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shown in Fig. 1C, illustrate an ene
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increasing toughness. These methods
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δD (‰ V-SMOW) 400 300 200 100 0
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L929 cell lines stably expressing t
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Fig. 6. cGAS binds to DNA in the cy
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k1 and k2 (byconservationofenergyan
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How do we answer this trilemma? As
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(9). For n = 3, where we used three
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computation in the presence of erro
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REPORTS greatly eases the requireme
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dynamically, therefore, Sr3Ru2O7 ca
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16. N. P. Ong, Phys. Rev. B 43, 193
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low-energy break in IC 443 and 21s
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32. T. Kamae, N. Karlsson, T. Mizun
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ferent structures rather than the e
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charge distribution, and DNA bindin
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ecause the efficiency of transcript
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precision and efficiency. To invest
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4. A. J. Wood et al., Science 333,
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targeting ~40.5% exons of genes in
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