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Transcriptional Characterization of Glioma Neural Stem Cells Diva ...

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6.7 Is<strong>of</strong>orm Differential Expression Results<br />

· AKT2: two reads map on the 3'UTR <strong>of</strong> the longest is<strong>of</strong>orm whilst one<br />

read maps on the 3'UTR <strong>of</strong> a shorter subset <strong>of</strong> is<strong>of</strong>orms;<br />

· AKT3: two reads map on the shortest is<strong>of</strong>orm and one on the 3'UTR<br />

and intron <strong>of</strong> the middle and longest is<strong>of</strong>orms, respectively;<br />

· BMP7: one read maps on the 3'UTR <strong>of</strong> the longest is<strong>of</strong>orm and one read<br />

on the 3'UTR <strong>of</strong> a middle-length set is<strong>of</strong>orms;<br />

· BRCA1: one read maps on the 3'UTR <strong>of</strong> the longest is<strong>of</strong>orm, whilst one<br />

read maps on an alternatively spliced exon, contained in a small subset<br />

<strong>of</strong> is<strong>of</strong>orms and which is a single is<strong>of</strong>orm itself;<br />

· CANX: all six reads map onto the 3'UTR <strong>of</strong> the longest is<strong>of</strong>orm, one on<br />

the 3'UTR <strong>of</strong> a shorter is<strong>of</strong>orm;<br />

· CTSB: three reads identify three different is<strong>of</strong>orms on their 3'UTRs;<br />

· ERBB2: two reads map on the 3'UTRs <strong>of</strong> two different is<strong>of</strong>orms (but<br />

one is not recognised by Ensembl Gene Predictions);<br />

· FGFR1: two reads map on the 3'UTRs <strong>of</strong> two different is<strong>of</strong>orms;<br />

· GRIA2: three reads identify three sets <strong>of</strong> lengths <strong>of</strong> is<strong>of</strong>orms on their<br />

3'UTRs with one identifying two <strong>of</strong> them;<br />

· HLA-A: two reads identify two different is<strong>of</strong>orms on their 3'UTR;<br />

· NBR1: one read maps on the 3'UTR <strong>of</strong> the longest is<strong>of</strong>orm and one read<br />

on a consistently present exon, which identifies also a shorter is<strong>of</strong>orm;<br />

· NFYC: two reads identify 3'UTRS <strong>of</strong> two different is<strong>of</strong>orms with one<br />

mapping between the 3'UTRs and last intron;<br />

· PTEN: two reads map on the 3'UTR <strong>of</strong> the longest is<strong>of</strong>orm and on the<br />

3'UTR <strong>of</strong> a much shorter is<strong>of</strong>orm;<br />

· RFX5: one read maps on the 3'UTR <strong>of</strong> two longer is<strong>of</strong>orms and one<br />

identifies a smaller subset <strong>of</strong> shorter ones on the 3'UTR;<br />

· NTRK2: two reads mapping on alternative 3'UTRs;<br />

· FGFR10P: one read maps on the 3'UTR and one on the fifth exon, which<br />

is displayed as a 3'UTR box on the Ensembl Prediction track;<br />

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