Transcriptional Characterization of Glioma Neural Stem Cells Diva ...

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D.1 Pathway Interactions Appendix First interactor Interaction Second interactor FGFR includes FGFR1 FOSL2 activates DEC1 FOSL2 activates RUNX1 FOXO includes FOXO3 FOXO leads-to APOPTOSIS FOXO3 activates-transcription CDKN1B FOXO3 activates-transcription FASLG GAB1 activates PI3K-class1a GADD45 activates CCND-CDK4/6-complex GADD45 activates MAP3K4 GADD45 interacts PCNA GRB2 activates GAB1 GRB2 activates SOS1 HIF1A leads-to HYPOXIA HLA-A leads-to CD8-T-CELL-ACTIVATION HLA-DM activates MHC-classII HLA-DM includes HLA-DMA HLA-DM includes HLA-DMB HLA-DM inhibits CD74 HLA-DRA interacts CBL IFI30 activates Endocytosed-antigen IFNG activates IFI30 IFNG activates Immunoproteasome IGF1 activates IGF1R IGF2 leads-to APOPTOSIS IGFBP5 inhibits IGF2 IKBKE activates NFKB IKBKE interacts MAP3K14 IL1B activates IL1R1 IL1B leads-to APOPTOSIS IL1B leads-to DIFFERENTIATION IL1B leads-to INFLAMMATION IL1B leads-to PROLIFERATION IL1R1 activates PIK3R1 IL1R1 activates TRAF2 IL1R1 activates TRAF6 ILK activates AKT1 IP3 activates ITPR1 IRAK1 activates MAP3K14 IRAK1 activates MAP3K1 IRS1 activates PI3K-class1a ITGB activates ILK ITGB activates PTK2 ITGB activates SHC ITGB includes ITGA4 ITGB includes ITGBL1 ITPR1 lets-in Calcium Immunoproteasome activates Cytosolic-antigen JUN leads-to DIFFERENTIATION JUN leads-to INFLAMMATION JUN leads-to PROLIFERATION MAP2K1/2 activates MAPK1/2 MAP2K4 activates MAPK14 MAP2K6 activates MAPK14 MAP2K7 activates MAPK8 MAP3K14 tentatively-activates NFKB MAP3K4 activates MAP2K4 MAP3K4 interacts TRAF4 MAP3K5 activates AKT1 MAP3K7 activates MAP3K14 MAPK1 activates ELK1 MAPK1 activates MAPT MAPK1/2 activates RPS6KA3 MAPK1/2 inhibits MAP2K1/2 MAPK1/2 inhibits SOS1 MAPK1/2 inhibits TSC2 MAPK14 activates DDIT3 MAPK8 activates JUN MAPK8 inhibits NFATC2 MAPT interacts S100B MAPT interacts SNCA MAPT leads-to MICROTUBULE-DISASSEMBLY MDM2 inhibits RB1 MDM2 inhibits TP53 MDM4 inhibits TP53 MHC-classI includes HLA-A 278
D.1 Pathway Interactions Appendix First interactor Interaction Second interactor MHC-classII includes HLA-DPA1 MHC-classII includes HLA-DPB1 MHC-classII includes HLA-DQA1 MHC-classII includes HLA-DQA2 MHC-classII includes HLA-DQB1 MHC-classII includes HLA-DRA MHC-classII includes HLA-DRB5 MHC-classII interacts CD74 MHC-classII leads-to CD4-T-CELL-ACTIVATION NFATC2 interacts EP300 NFKB leads-to ANTI-APOPTOSIS NFKB leads-to INFLAMMATION NFKB leads-to PROLIFERATION NFKBIZ inhibits NFKB NGF activates NTRK1 NR activates MAP2K6 NR includes NR0B1 NR includes NR1D1 NR includes NR4A2 NTRK1 activates TRAF6 NTRK1 interacts GRB2 NTRK1 interacts SHC1 NTRK2 activates TRAF6 NTRK2 interacts SHC1 PARP includes PARP12 PARP includes PARP3 PARP leads-to APOPTOSIS PDGF activates PDGFR PDGFR includes PDGFRA PDGFR includes PDGFRB PDGFR interacts CBL PDGFR interacts CRK PDGFR interacts PI3K-class1a PDK1 activates AKT1 PDPK1 activates AKT1 PEA15 interacts CASP8 PEA15 interacts MAPK1/2 PERP activates CYCS PHLPP1 inhibits AKT1 PI3K includes PI3K-class1a PI3K includes PI3K-class3 PI3K-class1a activates PIP2 PI3K-class1a interacts RB1 PI3K-class3 activates TORC1-complex PIP2 becomes DAG PIP2 becomes IP3 PIP2 becomes PIP3 PIP3 activates ILK PIP3 activates PDK1 PIP3 becomes PIP2 PIP3 interacts AKT1 PKC activates MAP2K1/2 PKC activates RAF1 PKC activates RAS PLC activates PIP2 PLCG activates PIP2 PLCG activates PKC PRKAB1 activates TSC-complex PRKDC activates TP53 PTEN inhibits AKT1 PTEN inhibits PIP3 PTEN inhibits PTK2 PTEN inhibits SHC PTEN inhibits TP53 PTEN interacts GAB1 PTEN interacts PIK3CA PTEN interacts PIK3R1 PTK2 activates MAP3K4 PTK2 activates PI3K-class1a PTK2 inhibits TSC-complex PTK2 interacts GRB2 PTK2 leads-to ACTIN-ORGANIZATION RAF1 activates MAP2K1/2 RAS activates PI3K RAS activates RAF1 RAS includes HRAS 279
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Transcriptional Characterization of
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This dissertation is my own work an
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Acknowledgements I would like to th
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5.9 External Dataset Expression Cor
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Introduction 1
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1.1 Glial Cells in the Central Nerv
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1.2 Glioblastoma Multiforme Introdu
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1.3 Primary and Secondary Glioblast
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1.4 Pathways Involved in Glioblasto
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1.5 Pathway Crosstalk Introduction
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Chapter 2 Neurogenesis Contents 2.1
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2.1 Radial Glia Introduction VZ adj
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2.2 Neural Stem Cells Introduction
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Chapter 3 Brain Cancer Stem Cells C
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3.1 The Cancer Stem Cell Hypothesis
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3.1 The Cancer Stem Cell Hypothesis
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3.2 Brain Cancer Stem Cells Introdu
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3.3 Glioma Culture Systems Introduc
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Chapter 4 The Non-Coding RNA World
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4.1 MicroRNA regulation Introductio
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4.1 MicroRNA regulation Introductio
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4.2 Target Prediction and Validatio
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Methods 93
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5.1 Tag-sequencing Data Processing
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5.1 Tag-sequencing Data Processing
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5.2 Array Comparative Genomic Hybri
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5.4 Quantitative Real Time-PCR Vali
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5.5 Literature Mining Methods Figur
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5.5 Literature Mining Methods How m
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5.6 Differential Isoform Expression
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5.9 External Dataset Expression Cor
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5.10 Glioblastoma Pathway Construct
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5.11 MicroRNA Target Prediction Ana
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Results 119
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6.2 Tag mapping Results Table 6.1:
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6.2 Tag mapping Results 123 Figure
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6.3 Copy Number Aberrations Results
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6.3 Copy Number Aberrations Results
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6.4 Core Differentially Expressed G
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6.5 Large-scale qRT-PCR Validation
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6.6 Literature Mining for Different
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6.7 Isoform Differential Expression
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6.8 Long ncRNA Differential Express
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6.8 Long ncRNA Differential Express
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Chapter 7 Dataset Correlation Analy
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7.1 Enrichment Analysis Results Tab
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7.1 Enrichment Analysis Results Fig
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7.1 Enrichment Analysis Results Tab
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7.2 Glioblastoma Expression Signatu
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7.3 Tumour Expression Correlation R
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7.4 Survival Analysis Results Table
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7.4 Survival Analysis Results 867 g
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7.5 Glioblastoma Pathway Analysis R
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8.1 Principles Results say, this is
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8.3 Databases Results Figure 8.1: O
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8.3 Databases Results Figure 8.3: W
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8.4 Filters Results Bayesian method
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8.5 Target Prediction Ensemble Anal
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9.1. Digital Profiling of GNS Cell
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Page 295 and 296: E. Exon Array Data Appendix Average
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Transcriptional Characterization of Glioma Neural Stem Cells Diva ...

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