Transcriptional Characterization of Glioma Neural Stem Cells Diva ...

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MicroRNA Array Data Appendix GNS NS microRNAs G7A G7B G26A G26B G144A G144B G166A G166B CB660A CB660B CB130A CB130B CB152A CB152B CB171A CB171B LogFC p-value FDR hsa-miR-762 5.94 6.4 5.5 6.29 5.68 5.74 5.03 5 5.45 5.68 3.69 2.78 4.47 4.76 3.59 3.62 1.4 1.79E-06 1.90E-05 hsa-miR-106b 13.58 13.74 12.99 12.97 12.23 12.14 10.91 11.37 10.44 9.66 11.5 11.39 11.85 11.57 11.84 11.7 1.2 1.51E-06 1.61E-05 hsa-miR-93 12.56 12.52 12.49 12.25 11.35 11.13 10.08 10.31 9.69 9.46 10.7 10.63 10.81 10.43 10.8 11.19 1.1 1.48E-06 1.59E-05 hsa-miR-1285 3.13 3.55 2.55 2.9 1.58 1.7 -0.07 0.87 -1.02 -1.13 -1.59 0.15 0.09 -0.66 -1.37 0.56 2.6 1.31E-06 1.44E-05 hsa-miR-630 7.37 7.13 7.81 7.71 6.67 8.1 4.32 4.61 7.43 7.17 3.79 3.73 5.18 4.9 3.9 4.38 1.7 1.30E-06 1.44E-05 hsa-miR-26a 11.67 11.8 9.99 10.19 12.63 12.51 8.54 9.09 9.77 9.52 9.48 8.59 9.23 9.48 9.69 9.14 1.4 1.27E-06 1.43E-05 hsa-miR-29c 10.44 10.67 10.87 10.79 9.45 9.3 10 10.6 8.67 7.33 8.65 8.65 8.85 8.65 9.13 9.17 1.6 1.04E-06 1.18E-05 hsa-miR-452 6.57 6.02 -0.35 0.35 0.28 1.01 0.14 -0.12 -0.7 -0.55 0.92 0.77 -0.59 0.3 -0.62 0.17 1.8 9.05E-07 1.05E-05 hsa-miR-188-5p 4.27 4.18 4.62 4.98 4.06 5.02 3.98 4.17 3.55 3.16 2.58 2.03 3.31 3.26 2.57 2.86 1.5 9.02E-07 1.05E-05 hsa-miR-483-5p 4.39 4.58 4.16 4.36 4.23 4.97 2.39 2.68 3.86 3.67 2.09 1.4 1.53 1.61 1.81 2.75 1.6 7.87E-07 9.49E-06 hsa-miR-1915* 1.48 1.38 0.81 0.77 0.11 0.1 0.13 0.61 -0.07 -0.07 -1.02 0.05 -1.03 -1.16 -1.43 -1.8 1.5 7.89E-07 9.49E-06 hsa-miR-589* 0 -0.11 -0.26 0.13 -1.23 -1.25 -0.61 -0.39 -2.07 -1.86 -1.75 -2.53 -1.32 -1.88 -2.12 -1.7 1.4 7.64E-07 9.35E-06 hsa-miR-664 6.32 6.25 5.29 5.7 5.05 4.98 3.68 3.76 4.76 4.64 3.65 3.45 3.98 4.14 3.8 3.6 1.1 7.06E-07 8.72E-06 hsa-miR-224 8.65 7.99 -0.01 -0.12 2.47 2.55 1.1 0.3 0.65 0.62 2.73 1.99 1.29 1.37 0.68 1.05 1.6 6.73E-07 8.47E-06 hsa-miR-550a* 6.74 6.7 5.88 5.58 4.63 4.43 5.17 5.4 3.48 3.74 4.4 4.88 4.28 4.04 4.64 4.97 1.3 6.09E-07 7.81E-06 hsa-miR-345 2.07 2.14 2.47 2.11 2.27 1.98 -0.24 0.64 -0.08 -0.89 -1.35 -1.19 0.16 -0.87 -0.42 0.85 2.2 5.78E-07 7.55E-06 hsa-miR-30b 9.44 9.35 10.26 10.06 8.15 7.81 8.54 9.23 7.63 7.22 7.53 6.77 8.09 7.83 7.8 7.21 1.6 5.83E-07 7.55E-06 hsa-miR-584 4.79 4.62 2.79 2.95 4.2 4.17 3.25 3.31 3.72 3.59 2.26 2.47 2.51 2.58 2.11 1.69 1.1 5.77E-07 7.55E-06 hsa-miR-4318 3.83 3.59 3.01 2.77 0.81 1.43 0.29 0.45 0.85 0.59 0.08 1.01 0.05 0.55 0.25 -0.01 1.6 5.25E-07 7.14E-06 hsa-miR-30d 10.35 10.36 11.76 11.52 9.9 9.71 9.85 10.28 9.65 9.67 8.76 8.04 9.35 9.52 9.01 8.57 1.4 5.13E-07 7.05E-06 hsa-miR-3607-3p 3.84 4.19 2.65 2.8 2.99 3.24 1.81 2.52 2.57 2.37 1.09 0.24 0.76 1.21 1.35 0.59 1.7 4.78E-07 6.64E-06 hsa-miR-3615 1.41 1.66 0.49 2.03 -1 -0.69 -1.13 -0.99 -0.88 -1.04 -2.26 -2.16 -1.5 -1.11 -2.12 -2.15 1.9 4.03E-07 5.78E-06 hsa-miR-30b* 3.86 4.01 4.77 4.68 3.11 2.8 4.27 4.48 1.68 1.65 2.31 2.07 3.26 2.19 2.91 2.03 1.7 4.12E-07 5.78E-06 hsa-miR-20b 11.79 11.98 12.66 12.56 11.47 11 9.71 10.31 9.53 8.79 10.12 10.32 9.38 9.01 10.32 10.94 1.6 4.06E-07 5.78E-06 hsa-miR-3194 2.54 3.02 2.44 3.35 2.56 2.62 2.27 2.32 1.4 1.44 0.36 0.19 1.39 1.95 0.56 1.04 1.6 4.12E-07 5.78E-06 hsa-miR-4298 4.97 5.17 4.64 5.02 3.79 4.53 3.44 3.42 3.58 3.61 2.05 1.99 2.48 2.56 2.37 3.35 1.6 4.10E-07 5.78E-06 hsa-miR-150* 5.95 6.28 5.47 6.35 5.13 5.06 5.64 5.59 5.05 5 3.62 3.41 4 4.31 4.05 3.43 1.6 3.34E-07 5.00E-06 hsa-miR-124 10.04 10.47 0.4 0.44 10.54 10.53 -0.55 -2.15 -0.75 -0.49 3 0.55 3.87 4.27 -1.24 0.93 3.7 3.25E-07 4.92E-06 hsa-miR-1915 8.53 8.9 7.81 8.78 8.27 8.24 9.02 8.95 7.8 7.7 6.14 5.3 6.86 7.44 6.35 5.59 1.9 3.21E-07 4.92E-06 hsa-miR-30d* 2.17 2.45 3.97 3.75 1.08 -0.17 2.72 3.96 -1.92 -3.21 -1.89 -2.27 1.98 -0.18 0.55 -0.8 3.5 2.97E-07 4.60E-06 hsa-miR-1273e 2.2 2.46 1.67 2.65 0.12 0.58 1.9 1.91 -1.25 -0.76 -0.47 -1 -0.08 -0.63 -0.9 0.54 2.3 2.89E-07 4.53E-06 hsa-miR-362-3p 6.21 6.42 5.81 5.88 6.59 6.13 3.96 4.66 4.6 2.9 2.81 1.56 4.23 3.44 2.04 2.72 2.7 2.75E-07 4.40E-06 hsa-miR-454 7.64 7.96 6.42 7.02 7.19 7.37 4.42 5.09 5.78 5.08 4.02 3.17 5.47 5.74 4.58 4.35 1.9 2.30E-07 3.73E-06 hsa-miR-877 1.92 2.27 1.23 2.56 0.53 1.25 1.31 1.16 -0.47 -0.81 -0.68 -1.04 -0.64 0.01 -0.78 -0.33 2.1 2.22E-07 3.65E-06 hsa-miR-500a* 5.75 5.85 5.83 5.87 6.44 5.94 4.86 5.05 5.08 5.16 3.73 3.81 4.6 4.62 4.07 4.32 1.3 2.22E-07 3.65E-06 hsa-miR-320c 8.03 7.86 7.77 7.7 7.12 7.2 6.9 7.17 6.81 6.46 5.75 5.26 6.16 6.24 5.92 6.25 1.4 2.11E-07 3.60E-06 hsa-miR-199a-3p 8.68 8.85 2.18 2.55 8.3 7.86 -0.76 -0.23 3.58 3.37 2.11 1.17 0.26 0.91 2.71 0.5 2.9 2.04E-07 3.52E-06 hsa-miR-423-5p 6.41 6.33 5.65 5.44 4.11 4.01 3.62 4.26 3.69 3.28 2.63 1.54 3.78 3.59 3.59 3.5 1.8 1.88E-07 3.29E-06 hsa-let-7b 14.64 14.61 14.02 13.92 13.3 13.16 12.82 13.47 11.75 11.16 12.1 11.67 12.29 12.13 12.49 11.41 1.9 1.84E-07 3.27E-06 hsa-miR-488* 2.77 3 3.28 3.89 3.88 4.41 -1.71 -1.63 -1.74 -1.57 1.4 0.02 -1.87 -1.09 1.77 0.39 2.6 1.69E-07 3.03E-06 hsa-miR-3065-5p 3.53 3.62 4.44 4.66 4.88 4.88 0.87 2 2.21 1.68 0.63 0.67 3.15 3.29 1.5 0.82 1.9 1.69E-07 3.03E-06 hsa-miR-32 4.12 3.99 0.34 1.75 4.14 4.43 -0.52 2.51 -3.73 -4.55 -0.98 -2.44 -1.46 -2.5 1.72 1.61 4.1 1.60E-07 2.96E-06 hsa-miR-320d 10.53 10.41 10.04 9.87 9.59 9.44 9.25 9.58 8.89 8.55 8.3 7.81 8.55 8.7 8.44 8.33 1.4 1.48E-07 2.80E-06 hsa-miR-4327 5.09 5.34 4.84 5.45 4.16 4.07 4.5 4.57 4.13 4 2.18 1.28 2.58 3.18 2.97 2.2 1.9 1.30E-07 2.53E-06 hsa-miR-361-3p 6.09 5.96 6.01 6.41 4.37 4.46 3.56 3.78 4.17 3.96 3.11 2.32 3.88 3.71 3.59 3.33 1.6 1.29E-07 2.53E-06 hsa-miR-664* 3.63 3.52 2.54 3.26 2.81 2.82 -0.19 0.11 2.11 2.34 -1.16 -1.32 0.55 0.33 0.37 -0.94 2 1.18E-07 2.38E-06 hsa-miR-492 3.09 3.1 1.97 2.97 2.41 2.41 2.91 2.83 1.16 0.44 0.52 -0.52 1.01 1.17 0.66 0.25 2.1 1.11E-07 2.26E-06 hsa-miR-424 12.87 12.79 11.31 11.95 12.07 12.87 9.77 10.36 11.39 9.36 7.33 6.82 11.52 11.17 6.66 6.88 2.9 1.01E-07 2.10E-06 hsa-miR-200b 5.36 5.23 4.31 4.7 3.76 2.92 1.85 2.79 1.95 2.39 1.72 0.64 1.96 2 0.63 1.19 2.3 1.01E-07 2.10E-06 hsa-miR-1181 7.14 7.72 6.28 6.94 5.95 5.79 6.61 6.53 5.36 5.38 4.6 4.5 4.75 5.29 4.81 4.28 1.7 9.04E-08 1.98E-06 hsa-miR-320e 9.82 9.74 9.31 9.2 8.9 8.77 8.46 8.79 8.17 7.83 7.46 6.98 7.7 7.89 7.61 7.75 1.5 9.16E-08 1.98E-06 hsa-miR-542-3p 8.8 9.12 6.99 8.06 8.24 8.95 6.1 6.4 7.57 6.34 3.77 2.8 8.08 7.74 2.97 2.63 2.6 8.39E-08 1.91E-06 304
F. MicroRNA Array Data Appendix GNS NS microRNAs G7A G7B G26A G26B G144A G144B G166A G166B CB660A CB660B CB130A CB130B CB152A CB152B CB171A CB171B LogFC p-value FDR hsa-miR-34c-3p 0.51 0.34 0.45 0.72 -1.75 -2.1 -1.58 -1.28 -1.98 -2.25 -2.4 -2.82 -1.66 -2.5 -2.5 -2.38 1.7 8.50E-08 1.91E-06 hsa-miR-3609 3.73 4.15 3.19 3.56 2.37 2.59 0.16 0.8 2.05 1.95 -0.71 -0.03 0.07 0.31 1.01 0.21 2 7.33E-08 1.70E-06 hsa-miR-25 13.1 13.05 12.06 12.09 11.86 11.63 9.99 10.44 9.88 9.54 10.44 10.44 10.6 10.29 10.65 10.74 1.5 7.07E-08 1.67E-06 hsa-miR-885-5p 6.59 6.58 1.25 1.99 5.06 4.58 -0.48 -0.72 1.21 0.84 0.33 -0.77 -0.51 -1 -0.12 1.66 2.9 6.18E-08 1.51E-06 hsa-miR-140-3p 9.2 8.7 7.21 7.27 9.37 9.37 5.29 5.58 6.43 6.14 6.02 5.74 6.37 6.17 6.38 6.2 1.6 3.99E-08 9.94E-07 hsa-miR-2276 5.71 6.43 3.34 4.75 4.85 4.87 4.99 4.7 3.26 3.2 -0.45 1.43 1.39 2.05 1.39 1.29 3.3 3.62E-08 9.29E-07 hsa-miR-338-3p 8.47 8.76 3.96 4.84 9.63 10.78 2.73 3.02 3.11 2.81 4.8 3.77 2.74 2.67 5.22 3.99 2.9 3.65E-08 9.29E-07 hsa-miR-502-5p 3.6 3.83 3.81 3.93 4.25 3.73 2.27 3.19 2.15 1.96 0.38 -0.44 2 0.92 0.16 0.91 2.6 3.54E-08 9.29E-07 hsa-miR-155 7.97 7.44 6.73 6.98 5.48 5.2 6.99 7.33 5.33 5.83 5.89 6.46 1.16 0.73 6.64 6.88 1.9 3.18E-08 8.56E-07 hsa-miR-542-5p 7.26 7.37 6.24 6.43 6.74 7.36 4.02 4.35 5.96 4.95 1.97 0.8 6.44 6.21 1.9 1.3 2.5 3.00E-08 8.25E-07 hsa-miR-362-5p 6.34 6.36 6.14 6.38 6.79 6.31 5.45 6.04 5.02 5.1 3.75 2.71 4.6 4.72 3.7 3.41 2.1 2.66E-08 7.45E-07 hsa-miR-4257 4.55 5.02 4.38 5.85 3.7 4.39 5.3 5.43 3.78 3 -0.77 -2.4 1.95 3.18 -0.18 -1.54 4 2.33E-08 6.82E-07 hsa-miR-186 7.64 7.91 7.63 8.02 6.22 6.45 5 5.23 6.1 5.84 4.05 4.45 5.53 5.39 4.59 4.81 1.7 2.21E-08 6.61E-07 hsa-miR-532-5p 5.94 6.13 5.81 6.05 6.54 6 5.01 5.69 4.49 4.39 3.08 2.29 4.39 4.37 3.6 2.98 2.2 1.65E-08 5.18E-07 hsa-miR-139-5p 4.27 4.37 1.34 1.36 6.36 6.21 -0.11 -0.38 -0.55 -0.17 -1.54 -0.77 -0.79 1.06 -1.36 -0.03 3.4 1.22E-08 4.00E-07 hsa-miR-192 7.99 8.26 6.54 6.97 6.23 6.13 5.47 5.69 5.43 5.24 5.13 4.95 4.99 4.91 4.67 4.68 1.7 1.13E-08 3.81E-07 hsa-miR-663 6.22 6.99 4.14 5.28 5.31 5.39 5.5 5.43 3.95 4.15 2.59 1.41 2.59 3.02 1.97 1.9 2.8 9.73E-09 3.36E-07 hsa-miR-29c* 4.32 4.33 5.6 5.47 2.58 2.59 4.21 4.51 2.57 1.53 0.55 1.21 3.03 3 1.9 2.01 2.2 9.57E-09 3.36E-07 hsa-miR-1972 2.46 3.57 0.98 2.45 0.4 0.91 1.29 2.52 -0.6 -1.88 -2.86 -2.53 -2.49 -2.18 -2.29 -2.09 3.9 5.28E-09 1.98E-07 hsa-miR-1208 4.58 4.72 3.55 4.49 4 3.75 4.5 4.67 2.59 1.82 1.53 1.46 2.53 2.85 1.21 1.35 2.4 5.32E-09 1.98E-07 hsa-miR-191 2.92 2.6 3.34 3.53 0.08 0.48 1.23 2.24 -0.52 -0.12 -1.04 -2.35 -1.68 -1.06 -1.58 -0.82 3.2 4.89E-09 1.95E-07 hsa-miR-339-5p 1.41 0.96 0.95 1.04 -1.15 -0.41 -1.43 -1.43 -2.38 -2.36 -2.41 -2.22 -1.76 -2 -2.24 -1.72 2.1 4.93E-09 1.95E-07 hsa-miR-501-3p 2.7 3.11 2.6 3.31 3.52 3.02 -1.01 -0.5 -0.65 0.1 -1.72 -1.98 0.06 -1.43 -1.86 -1.55 3.2 4.37E-09 1.84E-07 hsa-miR-424* 4.62 4.34 3.36 3.73 1.93 2.94 -0.62 -0.14 1.82 0.15 -2.63 -2.35 -0.24 -0.77 -2.08 -1.78 3.5 2.91E-09 1.27E-07 hsa-miR-488 6.31 6.56 6.22 6.64 6.88 7.3 -2.47 -2.52 -1.39 -1.59 5.08 4.09 -2.39 -1.8 5.27 4.24 2.9 2.65E-09 1.19E-07 hsa-miR-718 2.78 3.08 2.24 2.9 1.66 2.12 0.39 0.96 0.23 -0.8 -2.01 -2.28 -0.07 -1.32 -1.89 -2.09 3.3 2.26E-09 1.05E-07 hsa-miR-199b-5p 8.7 8.77 1.52 1.24 8.02 7.27 1.96 2.09 3.25 2.81 2.32 2.27 1.95 2.01 1.27 2.23 2.7 1.30E-09 6.50E-08 hsa-miR-10b* 7.24 7.18 0.71 0.53 3.88 4.1 2.21 2.49 -0.46 0.52 0.79 0.72 0.67 0.98 0.28 1.25 2.9 8.25E-10 4.27E-08 hsa-miR-532-3p 4.65 4.71 4.82 4.91 5.51 4.88 2.66 3.6 3.17 3.32 -0.71 -2.7 2.23 1.83 -2.24 -2.56 4.2 7.74E-10 4.17E-08 hsa-miR-135a* 3.87 4.15 3.08 3.76 2.86 2.68 3.38 3.03 2.8 1.96 -1.5 -2.16 -0.79 0.02 -0.38 -1.38 3.5 6.72E-10 3.77E-08 hsa-miR-215 6.72 6.99 5.17 5.69 4.99 4.88 3.79 4.02 3.52 3.18 2.87 2.57 2.53 2.89 2.82 2.86 2.4 4.79E-10 2.80E-08 hsa-miR-339-3p 1.65 1.69 2.03 2.15 0.97 0.42 -1.98 -0.75 -2.39 -2.82 -2.42 -2.9 -2.36 -2.83 -2.06 -2.14 3.3 4.13E-10 2.53E-08 hsa-miR-874 6.65 6.82 4.79 5.75 4.59 4.57 4.6 4.5 4.86 4.73 -1.2 -2.4 2.94 3.55 1.05 0.76 3.5 3.30E-10 2.12E-08 hsa-miR-10b 12.01 11.95 4.74 4.94 8.18 8.22 6.15 6.92 1.92 1.97 5.53 5.61 6.13 6.14 5.94 6.7 2.9 1.53E-10 1.03E-08 hsa-miR-625 5.69 5.92 4.53 4.94 3.78 3.84 4.83 5.15 -3.28 -3.06 3.82 4.1 3.8 3.84 3.99 4.53 2.6 1.46E-10 1.03E-08 hsa-miR-96 9.43 8.84 11.22 10.47 9.1 9.79 10.24 10.87 6.63 4.82 4.42 4.56 5.98 6.15 4.81 4.78 4.7 1.11E-10 8.33E-09 hsa-miR-450a 8.77 8.89 6.75 7.14 6.89 7.59 3.98 4.43 6.05 4.53 -1.22 -2.24 6.31 5.94 -1.08 -0.88 4.6 7.33E-11 5.81E-09 hsa-miR-1469 2.29 2.37 2.47 2.57 0.59 1.31 -1.04 0.19 -1.91 -2.45 -2.93 -2.7 -2.33 -2.22 -2.5 -2.79 3.8 5.98E-11 5.13E-09 hsa-miR-129-5p 3.05 3.21 1.45 1.72 4.88 4.14 -1.13 -0.49 -0.88 -0.41 -1.51 -1.32 -1.06 -0.83 -1.43 -1.42 3.2 6.09E-11 5.13E-09 hsa-miR-363 10.05 10.11 11.75 11.63 10.9 10.67 7.46 7.96 7.92 7.03 7.71 8.06 3.92 3.98 7.9 8.26 3.2 5.76E-11 5.13E-09 hsa-miR-378 6.65 6.4 3.26 4.84 7.16 6.8 -0.15 0.94 -2.19 -2.12 -2.12 -2.27 -1.57 -1.33 -2.01 -0.22 6.2 2.18E-11 2.49E-09 hsa-miR-183* 0.43 -0.16 3.65 2.92 1.27 2.35 3.42 4.08 -1.7 -2.32 -2.33 -2.41 -2.21 -2.35 -2.23 -1.97 4.4 2.00E-11 2.49E-09 hsa-miR-183 3.63 2.03 6.54 5.61 1.16 3.84 3.46 4.62 -4.24 -4.58 -4.79 -4.79 -4.44 -4.41 -4.63 -4.54 8.4 8.49E-12 1.27E-09 hsa-miR-194 5.86 6.18 4.32 4.75 3.78 3.57 0.69 1.93 0.94 0.47 -1.84 -3.02 -1.25 -1.49 -1.94 -2.22 5.2 7.16E-12 1.20E-09 hsa-miR-196a 8.87 9.09 5.05 4.64 5.86 5.37 6.27 6.68 0.42 0.32 -0.65 1.03 1.71 2.32 1.46 1.51 5.5 4.81E-12 9.25E-10 hsa-miR-138 4.97 5.22 5.48 4.16 5.2 4.91 -2.52 -2.22 -2.63 -2.61 -3.95 -3.78 4.31 3.81 -3.78 -3.46 4.7 4.18E-12 9.25E-10 hsa-miR-3648 4.88 4.92 4.35 4.93 4.06 4.87 4.18 4.35 3.87 3.07 -2.62 -2.85 -1.67 -0.53 -2.01 -2.07 5.2 3.29E-12 8.86E-10 hsa-miR-502-3p 4.53 4.56 4.46 4.67 4.9 4.3 1.96 2.49 2.78 2.4 -2.36 -2.05 0.39 0.87 -2.42 -1.88 4.3 1.98E-12 6.66E-10 hsa-miR-182 4.95 4.03 6.91 6.15 3.72 4.84 4.96 5.48 -0.98 -2 -3.14 -2.42 -2.19 -2.12 -2.96 -2.53 7.4 2.74E-13 1.23E-10 hsa-miR-148a 10.36 10.32 10.3 10.87 9.02 8.9 8.89 9.5 6.6 5.95 0 0.66 0.39 1.51 0.36 0.63 7.8 1.63E-14 1.10E-11 hsa-miR-196b 9.79 9.81 3.26 3.39 6.5 6.32 2.45 3.53 -3.08 -3.1 -3.77 -3.41 -2.81 -2.23 -3.57 -3.06 8.8 7.07E-16 9.52E-13 305
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Transcriptional Characterization of
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This dissertation is my own work an
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Acknowledgements I would like to th
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5.9 External Dataset Expression Cor
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Introduction 1
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1.1 Glial Cells in the Central Nerv
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1.2 Glioblastoma Multiforme Introdu
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1.3 Primary and Secondary Glioblast
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1.4 Pathways Involved in Glioblasto
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1.5 Pathway Crosstalk Introduction
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Chapter 2 Neurogenesis Contents 2.1
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2.1 Radial Glia Introduction VZ adj
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2.2 Neural Stem Cells Introduction
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Chapter 3 Brain Cancer Stem Cells C
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3.1 The Cancer Stem Cell Hypothesis
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3.1 The Cancer Stem Cell Hypothesis
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3.2 Brain Cancer Stem Cells Introdu
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3.3 Glioma Culture Systems Introduc
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Chapter 4 The Non-Coding RNA World
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4.1 MicroRNA regulation Introductio
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4.1 MicroRNA regulation Introductio
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4.2 Target Prediction and Validatio
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Methods 93
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5.1 Tag-sequencing Data Processing
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5.1 Tag-sequencing Data Processing
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5.2 Array Comparative Genomic Hybri
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5.4 Quantitative Real Time-PCR Vali
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5.5 Literature Mining Methods Figur
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5.5 Literature Mining Methods How m
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5.6 Differential Isoform Expression
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5.9 External Dataset Expression Cor
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5.10 Glioblastoma Pathway Construct
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5.11 MicroRNA Target Prediction Ana
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Results 119
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6.2 Tag mapping Results Table 6.1:
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6.2 Tag mapping Results 123 Figure
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6.3 Copy Number Aberrations Results
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6.3 Copy Number Aberrations Results
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6.4 Core Differentially Expressed G
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6.5 Large-scale qRT-PCR Validation
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6.6 Literature Mining for Different
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6.7 Isoform Differential Expression
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6.8 Long ncRNA Differential Express
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6.8 Long ncRNA Differential Express
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Chapter 7 Dataset Correlation Analy
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7.1 Enrichment Analysis Results Tab
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7.1 Enrichment Analysis Results Fig
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7.1 Enrichment Analysis Results Tab
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7.2 Glioblastoma Expression Signatu
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7.3 Tumour Expression Correlation R
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7.4 Survival Analysis Results Table
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7.4 Survival Analysis Results 867 g
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7.5 Glioblastoma Pathway Analysis R
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8.1 Principles Results say, this is
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8.3 Databases Results Figure 8.1: O
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8.3 Databases Results Figure 8.3: W
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8.4 Filters Results Bayesian method
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8.5 Target Prediction Ensemble Anal
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9.1. Digital Profiling of GNS Cell
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9.2. MicroRNA Target Prediction Ana
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9.3. Concluding Remarks Appendix pr
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A.1 Differential Expression Appendi
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A.2 Classified Differential Express
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Page 273 and 274: A.4 Tag-seq vs qRT-PCR Correlation
Page 275 and 276: Appendix "BEX5", "DIAPH2", "GBP3",
Page 277 and 278: End Select End If End Sub Appendix
Page 279 and 280: If NameStr.ToLower().Equals("query"
Page 281 and 282: Appendix C Long ncRNAs We detected
Page 283 and 284: C. Long ncRNAs Appendix Tag Accessi
Page 285 and 286: D.1 Pathway Interactions Appendix F
Page 291 and 292: D.2 Pathway Images Appendix Figure
Page 293 and 294: D.2 Pathway Images Appendix Figure
Page 295 and 296: E. Exon Array Data Appendix Average
Page 309 and 310: F. MicroRNA Array Data Appendix Tab
Page 311: F. MicroRNA Array Data Appendix GNS
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Page 317 and 318: 3.3 Schematisation of cell cycle ph
Page 319 and 320: 8.3 Workflows at the core of the pr
Page 321 and 322: 7.1 Selected Gene Ontology terms an
Page 323 and 324: Bibliography [1] Cell signaling tec
Page 325 and 326: [38] G. Bain, D. Kitchens, M. Yao,
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Page 349 and 350: [490] P. A. C. t’Hoen, Y. Ariyure
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