Experimentelle Untersuchungen zur Transgenese bei Nutztieren

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6.0 Literaturverzeichnis Adelson, D.L. 2008. Insights and applications from sequencing the bovine genome. Reproduction, Fertility and Development 20:54-60. Anger, M., Kues, W.A., Klima, J., Mielenz, M., Motlik, J., Carnwath, J.W. and Niemann, H. 2003 Cloning and cell cycle-specific regulation of Polo-like kinase in porcine fetal fibroblasts. Molecular Reproduction and Development 65, 245-253. Avery, O.T., MacLeod, C.M., McCarty, M. 1944. Studies on the chemical nature of the substance inducing transformation of pneumococcal types. J. Exp. Med. 79, 137-158. Bach, F. H. 1998. Xenotransplantation: Problems and prospects. Annu. Rev. Med. 49, 301- 310. Bennett, S.T., Barnes C., Cox, A., Davies, L, Brown, C. 2005. Toward the 1,000 dollars human genome. Pharmacogenomics 6, 373-82. Bird, A. 1992. The essentials of DNA methylation. Cell. 70, 5-8. Brackett, B.G., Baranska, W., Sawicki, W., Koprowski, H. 1971.Uptake of heterologous genome by mammalian spermatozoa and its transfer to ova through fertilization. Proc Natl Acad Sci U S A. 68, 353-7. Brem, G., Brenig, B., Goodman, H. M., Selden, R. C., Graf, F.,Kruff, B., Springmann, K., Hondele, J., Meyer, J., Winnacker, E.L. & Kr.ausslich, H. 1985. Production of transgenic mice, rabbits and pigs by microinjection into pronuclei. Zuchthygiene 20, 251—252. Brophy, B., Smolenski, G., Wheeler, T., Wells, D., L'Huillier, P., and Laible, G. 2003. Cloned transgenic cattle produce milk with higher levels of b-casein and k-casein. Nat. Biotechnol. 21, 157–162. Caligari, F., Marzesco, A.M., Kittler, R. et al., 2004. Tissue-specific RNAi in postimplantation mouse embryos using directional electroporation and whole embryo culture. Differentiation 72, 92-102. Capecchi, M.R. 1989. The new mouse genetics: altering the genome by gene targeting. Trends Genetics 5, 70-76. Cibelli, J. B., Stice, S. L., Golueke, P. L., Kane, J. J., Jerry, J., Blackwell, C., Ponce de Leon, F. A., and Robl, J. M. 1998. Transgenic bovine chimeric offspring produced from somatic cell-derived stem like cells. Nat. Biotechnol. 16, 642-646. Chan, A. W., Homan, E. J., Ballou, L. U., Burns, J. C., and Bremel, R. D. 1998. Transgenic cattle produced by reverse-transcribed gene transfer in oocytes. Proc. Natl. Acad. Sci. USA 95, 14028-14033. Chandler, L.A., Jones, P.A. 1988. Hypomethylation of DNA in the regulation of gene expression. Dev Biol 5, 335-49. 40
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Page 1 and 2: Aus dem Institut für Nutztiergenet
Page 3 and 4: Inhaltsverzeichnis 1.0 Eigene Publi
Page 5 and 6: Dieckhoff, B., Petersen, B., Kues,
Page 7 and 8: Bereits 1971 wurden durch Inkubatio
Page 9 and 10: sowie Reproduktion und Krankheitsre
Page 11 and 12: eine verbesserte Allokation und die
Page 13 and 14: 2.5 Transgene Tiere für landwirtsc
Page 15 and 16: Über die homologe Rekombination in
Page 17 and 18: integriert trugen; die Fremd-DNA wa
Page 19 and 20: Abb.5. Konditionale Expressionskont
Page 21 and 22: Belgier und Piedmonteser, sind durc
Page 23 and 24: Abb. 7. Die DNA-Methyltransferase (
Page 25 and 26: 4.0 Ergebnisse und Diskussion Im Er
Page 27 and 28: eseeding of outgrowing cells Tissue
Page 29 and 30: 4.2 Gene knock-down Versuche in tra
Page 31 and 32: vermieden werden. Um zu bestimmen,
Page 33 and 34: starke Expression von hCD59 in Pank
Page 35 and 36: Zellpopulationen als auch in Einzel
Page 37 and 38: ei doppelttransgenen Schweine wurde
Page 39: 5.0 Zusammenfassung In der vorliege
Page 43 and 44: Golding, M.C., Long, C.R., Carmell,
Page 45 and 46: Kambadur, R., Sharma, M., Smith, T.
Page 47 and 48: Maatouk, D.M., Kellam, L.D., Mann,
Page 49 and 50: Orban, PC, Chui, D, Marth, JD 1992.
Page 51 and 52: Schuelke, M., Wagner, K.R., Stolz,
Page 53 and 54: Yarranton, GT. 1992. Inducible vect
Page 55 and 56: 8.0 Darstellung des eigenen Anteils
Page 57 and 58: Iqbal, K, Kues, W.A., Niemann, H. 2
Page 59 and 60: 9. Abkürzungsverzeichnis ACTB ß-A
Page 61 and 62: Abstract Animal Reproduction Scienc
Page 63 and 64: H. Niemann, W.A. Kues / Animal Repr
Page 87: H. Niemann, W.A. Kues / Animal Repr
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246 M. ANGER ET AL. cell cycle in p
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248 M. ANGER ET AL. Statistical Ana
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250 M. ANGER ET AL. Fig. 2. Express
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252 M. ANGER ET AL. Fig. 4. Compara
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Telomere length is reset during ear
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Fig. 2. Telomere length of cloned a
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9. Rudolph, K. L., Chang, S., Lee,
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Review TRENDS in Biotechnology Vol.
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Xenotransplantation of porcine orga
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as a novel therapy for liver diseas
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3 Rudolph, N.S. (1999) Biopharmaceu
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BIOLOGY OF REPRODUCTION 72, 1020-10
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1022 KUES ET AL. FIG. 1. Activation
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1024 KUES ET AL. FIG. 3. Induction
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1026 KUES ET AL. FIG. 4. Growth cha
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1028 KUES ET AL. 31. Engstrom U, En
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2 P.S. YADAV ET AL. in agriculture
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4 P.S. YADAV ET AL. Fig. 1. Oct4 bu
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6 P.S. YADAV ET AL. individual cell
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8 P.S. YADAV ET AL. TABLE 5. Mainte
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Rev. sci. tech. Off. int. Epiz., 20
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The FASEB Journal Express article f
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To detect CD59 and DAF, immunohisto
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TABLE 1. Expression patterns in ani
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Figure 5. Expression patterns of hD
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demonstrated in transgenic pigs and
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Xenotransplantation 2006: 13: 345-3
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Table 1. Age, sex and transgenic co
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For color development, slides were
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Table 3. Pattern of hCD59 protein e
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thelial cells of small and medium b
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CMV-derived promoter expression can
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Arch Virol (2006) DOI 10.1007/s0070
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Inhibition of PERV expression by RN
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Inhibition of PERV expression by RN
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Parent-of-origin dependent gene-spe
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Fig. 1. (A) Expression of GFP in F1
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An important finding of this study
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CLONING AND STEM CELLS Volume 9, Nu
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366 FIG. 2. Floating spheroids in s
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368 oids and used as donor cells. A
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370 FIG. 4. The three vital piglets
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372 transferase gene knockout pigs.
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CSIRO PUBLISHING Reproduction, Fert
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764 Reproduction, Fertility and Dev
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Abstract Author's personal copy App
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necessary to provide the large numb
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analysis and the information conten
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maternal to embryonic genomic activ
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were determined for individual mous
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References [1] Goodstadt L, Ponting
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inter- and intraplatform reproducib
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2 Perspectives in Agriculture, Vete
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10 Perspectives in Agriculture, Vet
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integrated in the porcine genome [6
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smaller than 200 nucleotides accord
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normalization (total RNA amount or
Page 262 and 263:
References 1. Cooper DK. Clinical x
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mammalian gene expression by small
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