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3rd International Congress 3rd International of Nuclear Congress Medicine of Nuclear & 15th Medicine Iranian Annual & 15th Iranian Congress Annual of Nuclear Congress Medicine of Nuclear Medicine Shahid Beheshti Shahid Beheshti University University of Medical Sciences of Medical 19-21 Sciences May 201119-21 May 2011 Radiolabeling of ceftriaxone with 99mTc for detecting site of infection in mouse model Akram Fazli, Gholamreza Ahmadi, Mojtaba Salouti, Shahrzad Mirshojaei Introduction: Although our understanding of microorganisms has advanced significantly and antimicrobial therapy has become increasingly available, infection remains a major cause of patient morbidity and mortality. The use of radiopharmaceuticals for diagnosis of infection is increasing due to their ability to distinguish between septic and aseptic inflammation. Aims: The aim of this work was, labeling of ceftriaxone (a cephalosporin antibiotic) with 99mTc for Staphylococcus aureus infection diagnosis in nuclear medicine. Methods: Radiolabeling of ceftriaxone was carried out by adding 99mTc to ceftriaxone (1.5 µCi to 1 mg) in the presence of SnCl2.2H2O at PH 5.5. The radiolabeling yield and radiochemical purity of product was evaluated with ITLC. The mice were induced infection intramusculary with Staphylococcus aureus and strile inflammations with turpentine oil. The biodistribiotion and scintigraphy imaging were performed at 1, 4 and 16h post injection. Results: Radiochemical yield of product was 94±5% with a good stability in room temperature and human serum. The biodistribution and scintigraphic imaging studies showed the specific localization of 99mTc-ceftriaxone at the site of infection in relation to inflamated leg and other organs with high sensivity. Conclutions: One may consider 99mTc-ceftriaxone as a promissing candidate for Staphylococcus aureus infection diagnosis in nuclear medicine. Keywords: Radiolabeling, Infection, Biodistribution, Scintigraphy 124
3rd International Congress of of Nuclear Medicine & & 15th 15th Iranian Annual Annual Congress of Congress of Nuclear Medicine Shahid Beheshti Shahid Beheshti University University of Medical of Medical Sciences Sciences 19-21 19-21 May May 2011 Correlation of circulating omentin-1 with bone mineral density in multiple sclerosis: the crosstalk between bone and adipose tissue Majid Assadi 1 , Hooman Salimipour 2 , Samad Akbarzadeh 3 , Zahra Samani 1 , Reza Nemati 2 , Seyed Mojtaba Jafari 4 , Mohammad Seyedabadi 1 , Iraj Nabipour 4 1 The Persian Gulf Nuclear Medicine Research Center 2 Department of Neurology 3 Department of Biochemistry 4 Department of Endocrine and Metabolic Diseases Introduction: Adipose tissue-derived adipokines play important roles in inflammatory and autoimmunediseases. Although the relationship of adipokines with chondrocyte function and the skeleton have been investigated, the role of novel adipokines (e.g., omentin-1 and vaspin) in osteoimmunology remains to be elucidated. Patients with multiple sclerosis (MS) are at increased risk of osteoporosis and fractures. Methods: In order to investigate circulating levels of these novel adipokines in relation to bone health in MS, 35 ambulatory MS patients with elapsingremitting courses were compared with 38 healthy age- and sex-matched healthy controls. Bone mineral density (BMD) was determined for the lumbar spine (L2-L4) and the proximal femur using dual-energy x-ray absorptiometry. Circulating omentin- 1, vaspin, osteocalcin, osteopontin, osteoprotegerin, the receptor activator of nuclear factor-ĸB ligand, matrix metalloproteinase 9, and C-reactive protein were evaluated by highly specific enzyme-linked immunosorbent assay methods. Results: There was no significant difference between the two groups regarding bone-related cytokines, adipocytokines, and the BMD measurements of patients with MS and the healthy controls. However, age- and body mass index- adjusted circulating omentin-1 levels were positively correlated with BMD at the femoral neck (r= 0.44, p=0.017), total hip (r=0.41, p=0.027), osteopontin (r=0.44, p=0.031) and osteocalcin (r=0.47, p=0.012) in MS patients. No correlations were found between vaspin, biochemical, and BMD measures in both groups. Conclusion: Elevated omentin-1 serum levels are correlated with BMD at the femoral neck and the serum levels of osteocalcin and osteopontin in MS patients. Therefore, there is crosstalk between adipose tissue and bone in MS as an autoimmune disorder. Keywords: Multiple sclerosis, Bone mineral density, Omentin-1 125
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