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3rd International Congress 3rd International of Nuclear Congress Medicine of Nuclear & 15th Medicine Iranian Annual & 15th Iranian Congress Annual of Nuclear Congress Medicine of Nuclear Medicine Shahid Beheshti Shahid Beheshti University University of Medical Sciences of Medical 19-21 Sciences May 201119-21 May 2011 Calculation of absorbed dose in human body produced by PET machine using MCNP code Masood Abdolahzade 1 , Atiyeh Moshayedi 2 , Hasan Yousefnia 3 , Yaser Kasesaz 3 , Davood Ghasemabadi 1 , Mohsen Shayeste 1 1 Imam Hossein University 2 Tehran Center Azad University 3 Atomic Energy Organization of Iran In This paper the gamma absorbed dose in a simulated phantom of adult human body is calculated. The 0.5 MeV gamma rays are produced in positron annihilation process in PET device. A certain amount of F-FDG18 drag is injected in human body to positron emission by F-18 isotope and gamma production in organs ob body. The MCNP code is used for phantom and radiation simulation. The good results are obtained and compared with other works. Keywords: PET 90
3rd International Congress of of Nuclear Medicine & & 15th 15th Iranian Annual Annual Congress of Congress of Nuclear Medicine Shahid Beheshti Shahid Beheshti University University of Medical of Medical Sciences Sciences 19-21 19-21 May May 2011 Evaluation of single dose 99m Tc-MIBI as a myocardial imaging agent in clinical test G.A. Shabani, H.R. Khosrounejad, M. Farahani, F. Hajhasan Abbasi, M. Goudarzi, M.H. Talebi, M. Mazidi Radioisotope research group, NSTRI, Atomic Energy org. of Iran Introduction: 99m Tc-sestamibi (MIBI) is widely used in evaluation of myocardial perfusion abnormalities. The radiopharmaceutical 99m Tc- MIBI is a monovalent cation in which 99mTc is surround by six isonitril ligands. 99m Tc-sestamibi is prepared from a kit and required boiling to effect labeling. 99m Tc-MIBI diffuses passively out of the blood and apparently localizes in mitochondria on the basis of their negative electrical potentials. Materials and methods: in new formulation of 99m Tc-MIBI as a single dose, for one patient, we changed the formulation and reduced the amount of MIBI. Finally, the kit lyophilized and checked QC, biodistribution in mice, shelf life, sterility and pyrogeuicity test. For checking in clinical test, we sent to some nuclear medicine centers. Results: Radiolabelling was performed by ITLC chromatography and it was more than 95 percent up to 30 mCi of 99m Tc. Conclusion: this study demonstrated that the new formulation of 99m Tc-MIBI as a single dose is a useful method for myocardial imaging of one patient in nuclear medicine centers. Keywords: MIBI, myocardial, radiopharmaceutical, 99m Tc 91
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