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3rd International Congress 3rd International of Nuclear Congress Medicine of Nuclear & 15th Medicine Iranian Annual & 15th Iranian Congress Annual of Nuclear Congress Medicine of Nuclear Medicine Shahid Beheshti Shahid Beheshti University University of Medical Sciences of Medical 19-21 Sciences May 201119-21 May 2011 Radiolabeled annexin V imaging: a useful technique for determining apoptosis in multiple sclerosis Majid Assadi 1 , Reza Nemati 2 , Iraj Nabipour 1 , Hooman Salimipour 2 , Abdullatif Amini 1 1 The Persian Gulf Nuclear Medicine Research Center 2 Department of Neurology Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) that involves myelin, oligodendrocytes and axons and culminates in consecutive neuronal death and progressive neurologic disability. Based on magnetic resonance imaging (MRI), neuroaxonal loss in MS results in brain atrophy and has a strong correlation with neurological disability. The newer MR imaging tools seem to be sensitive biomarkers for measuring the pathogenetic processes associated with disease activity and progression. However, it has been difficult to predict the prognosis of MS patients undergoing an exacerbation from the cross-sectional area of the contrast-enhanced lesions seen on MRI (or with FLARE MRI). The edema assocaited with MS lesions creates confusion between changes in extracellular fluid space and damage to the neuronal elements. Annexin V has a high affinity for phosphatidylserine (PS) that presents on the outer surface of the plasma membrane early on during the onset of apoptosis. Radiolabeled annexin V imaging may reveal the initiation and degree of neuronal apoptosis. It is our expectation that annexin will pass through the blood-brain-barrier at the site of new lesions and localize at the site of stressed or damaged neurons. The extent of localization should be proportional to the extent of damage to the cellular elements of the brain. Thus, we expect a much better correlation of annexin imaging to prognosis. Based on this model, it might be good to image as soon as possible after clinical presentation of an exacerbation to determine the extent of neuronal involvement and then to do a follow up study about 14 days post treatment to determine response to therapeutic intervention. Such studies should provide specific information on severity and prognosis of the and on individual response to treatment. We hypothesize that radiolabeled annexin V imaging is a useful modality in the determination of apoptosis in MS and can assess and monitor the effectiveness of neuroprotective and immunomodulatory therapies on the clinical course of MS. It would be productive to study MS patients with Tc-99m annexin V imaging. Unfortunately, this cold kit is unavailable for human use in the world. Keywords: Multiple sclerosis , phosphatidylserine 162
3rd International Congress of of Nuclear Medicine & & 15th 15th Iranian Annual Annual Congress of Congress of Nuclear Medicine Shahid Beheshti Shahid Beheshti University University of Medical of Medical Sciences Sciences 19-21 19-21 May May 2011 Comparison between Neutron Flux and Spectrum in North Beam Tubes of Tehran Research Reactor by MCNP4C Code for BNCT Majid Zamani, Hossein Khalafi, Yaser Kasesaz, Mohsen Shayesteh In order to investigate the possibility of using the T.R.R beam tubes in BNCT, it is necessary to select the best one from three north beam tubes. This beam tube should have more flux and better spectrum compare to others. So, after simulation of the last configuration of reactor’s core (NO.55) by MCNP4C code, the neutron flux and spectrum were calculated at the start, middle, and end of each three north beam tubes (B1, B2, B3). Because of the relation between these parameters and the state of core, this calculation has been done in three different situations of reactor’s core: BOC, MOC and EOC. The analyses of results showed that the neutron spectrum is almost the same in all of the beam tubes, but the neutron flux in northwest beam tube is better than the others .so, this beam tube is more proper to be used in BNCT. Keywords: BNCT, Reactor, MCNP4C, Tubeon Flux 163
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