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3rd International Congress 3rd International of Nuclear Congress Medicine of Nuclear & 15th Medicine Iranian Annual & 15th Iranian Congress Annual of<br />
Nuclear Congress Medicine of Nuclear Medicine<br />
Shahid Beheshti Shahid Beheshti University University of Medical Sciences of Medical 19-21 Sciences May 201119-21 May 2011<br />
Preparation, quality control and biodistribution studies of<br />
[61Cu]-doxorubicin for PET tumor imaging<br />
Amir Reza Jalilian 1 , Hassan Yousefnia 1 , Reza Faghihi 2 , Mehdi<br />
Akhlaghi 1 , Hassan Zandi 1<br />
1 Nuclear Science and Technology Research Institute<br />
2 Shiraz University<br />
This work was conducted for radiolabeling of an anticancer antibiotic,<br />
i.e. doxorubicin with Cu-61 for production of possible tracer used in<br />
PET oncology. Cu-61 was prepared from natural zinc target<br />
irradiation by 22 MeV protons (150 A) via nuclear reaction with a<br />
yield of 3.33 mCi/µAh. In order to obtain the best labeling method<br />
optimization reactions were performed for pH, temperature and<br />
concentration. Biodistribution of the tracer was studied in normal and<br />
fibrosarcoma bearing mice. At the optimized conditions, ITLC showed<br />
radiochemical purity more than 97% with a specific activity of 0.06<br />
Ci/mM. This was kept unchanged even with presence of human<br />
serum as well as room temperature for 5h. Biodistribution of the<br />
tracer in fibrosarcoma bearing mice demonstrated significant tumor<br />
uptake after 2h. This tracer can be used in the detection of various<br />
tumors responding to doxorubicin chemotherapy using PET scan<br />
and/or determination of tumor therapy response to doxorubicin<br />
chemotherapy.<br />
Keywords: Copper-61, Doxorubicin, Radiolabeling, Biodistribution<br />
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