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3rd International Congress 3rd International of Nuclear Congress Medicine of Nuclear & 15th Medicine Iranian Annual & 15th Iranian Congress Annual of Nuclear Congress Medicine of Nuclear Medicine Shahid Beheshti Shahid Beheshti University University of Medical Sciences of Medical 19-21 Sciences May 201119-21 May 2011 Evaluation of 153 Sm-EDTMP as a therapeutic radiopharmaceutical for bone pain palliation in clinical test G.A. Shabani, H.R. Khosrounejad, F. Hajhasan Abbasi, M. Farahani, M. Goudarzi, Y.H. Tavakoli, M.H. Talebi Radioisotope research group, NSTRI, Atomic Energy org. of Iran, Introduction: Owing to its favorable decay characteristic of 153 Sm[t 12 =46.27h, Eβ (max) =810 KeV and Eγ=103KeV] and EDTMP (Ethylene diamine tetra methylene phosphonate as a ligands, is one of the most widely used as therapeutic radiopharmaceutical for bone pain palliation. Also it was approved by FDA in 1997. Methods: Enriched 152 Sm target was irradiated by thermal neutron flux in Tehran research reactor then dissolved in acidic media; EDTMP was dissolved in DDW. After labelling, the QC and RCP were done by ITLC chromatography. Results: Radiochemical purity of 153 Sm-EDTMP was more than 98 percent at RT. Biodistribution in rat was the same the other references. Conclusion: More than 20 patients received our produced 153 Sm- EDTMP as a bone pain palliation. Keywords: 153 Sm, Bone Pain palliation, EDTMP 146
3rd International Congress of of Nuclear Medicine & & 15th 15th Iranian Annual Annual Congress of Congress of Nuclear Medicine Shahid Beheshti Shahid Beheshti University University of Medical of Medical Sciences Sciences 19-21 19-21 May May 2011 Photon scatter and penetration in parallel hole collimator in preclinical Gamma Camera: A Monte Carlo study Farzaneh Adibpour 1 , Mohammad Reza Ay 1 , Saeed Sarkar 1 , George Loudos 2 1 Department of Medical Physics and Biomedical Engineering 2 Department of Medical Instrument Technology Introduction: Parallel hole SPECT is rapidly obtaining popularity for preclinical imaging using gamma-emitting molecules. Scatter and septal penetration degrade contrast and quantitative accuracy in SPECT. The magnitude of penetrated and scattered photons depends on the photon’s energy, object under study and collimator design parameters. The main goal of this study is to quantify the effects of penetration and scatter as function of collimator thickness and septa with parallel hole collimator (made of lead). Methods: In this study, GATE was applied for accurate modeling of collimator. In order to separate the contribution of scatter and penetration components, we simulated Tc-99m and I-131 point sources in air,5cm away from the detector surface. To evaluate penetration and scatter in collimator, three different classes are considered in order to classify the registered events. In first category there are photons which were registered within the crystal under which the source has been located. This group is called true photons. In the second group, penetration occurs when the photon without any interaction with collimator, are detected in another crystal. Third category belongs to photons incident which experience one or more scatter interaction in collimator and finally were registered in another crystal. Result: Simulation results demonstrated that in case of Tc-99m point source with collimator thickness of 10mm only approximately 18% of the photons detected resulted from both penetration and scatter while this ratio will increase to 85% for I-131.By increasing collimator thickness fraction of photons undergo penetration and scattering decrease particularly for collimator thickness above 25mm(for 140keV photons).The results also indicate, increasing collimator septa from 0.1 to 0.4 leads to 8% decrease in penetration and scatter in our desired energy window. Conclusion: The current assessment of septal penetration and septal scatter in parallel hole collimator not only provides a deeper understanding of their respective contributions but is also aimed to be utilized for optimization of collimator design in high resolution preclinical imaging. Keywords: septal penetration, septal scatter, parallel hole collimator 147
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