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3rd International Congress 3rd International of Nuclear Congress Medicine of Nuclear & 15th Medicine Iranian Annual & 15th Iranian Congress Annual of Nuclear Congress Medicine of Nuclear Medicine Shahid Beheshti Shahid Beheshti University University of Medical Sciences of Medical 19-21 Sciences May 201119-21 May 2011 Update of V/Q Scan in Diagnosis of Pulmonary Thromboembolism Elahe Pirayesh Shahid Beheshti University of Medical Science, Shohada e Tajrish Hospital, Nuclear Medicine Department Perfusion-ventilation (V/Q) scintigraphy was introduced in 1964 and for several decades it was the only widely available method in imaging patients with suspected PE. The development of helical CT in the early 1990s provides a new means of imaging. Advanced technology of multidetector CT angiography (MDCTA) improved the ability of CT to depict small and subsegmental emboli. In view of increasing competition of CTA with V/Q scan, modernization of the conventional V/Q lung scan seems essential. V/Q SPECT as a mature technique has been shown to be obviously superior to planar V/Q in diagnosis of PTE. It is also associated a lower number of inconclusive reports; without limitations of CTA, including high radiation dose, pregnancy, renal failure and contrast allergy. Comparing MDCTA and V/Q scan also show equal sensitivity, specificity and accuracy of two techniques. So, many authors believe the enormous increase in the number of MDCTA must be reversed; not only because of unacceptably high radiation exposure, but also because of erroneous belief that it is a superior diagnostic tool as compared with V/Q SPECT imaging. SPECT/CT combines the high sensitivity of SPECT with the high specificity of CTPA and improves the diagnostic accuracy. SPECT/CT image fusion may be useful in cases of inconclusive CTPA imaging. Probabilistic interpretation of V/Q SPECT is also should be replaced by a holistic interpretation strategy on the basis of all relevant information about the patient. Keyword: perfusion ventilation scan, PTE, SPECT 70
3rd International Congress of of Nuclear Medicine & & 15th 15th Iranian Annual Annual Congress of Congress of Nuclear Medicine Shahid Beheshti Shahid Beheshti University University of Medical of Medical Sciences Sciences 19-21 19-21 May May 2011 Preliminary Imaging Studies of [61Cu] diacetyl-bis (N4- methylthiosemicarbazone) Amir Reza Jalilian, Hasan Yousefnia, Mohsen Kamali-dehghan, Sedigheh Moradkhani, Fatemeh Bolourinovin, Kamaleddin Shafaii, Gholamreza Aslani Nuclear science and technology research institute [61Cu] diacetyl-bis (N4-methylthiosemicarbazone) ([61Cu] ATSM) is a well-established hypoxia imaging tracer with simple production and significant specificity. In this work the accumulation of the tracer is studied in wild-type, necrotic and hypoxic fibrosarcoma tumors. [61Cu]ATSM was prepared using ATSM ligand and [61Cu]CuOAc followed by i.v. administration and imaging studies in wild-type rats and hypoxic fibrosarcoma-bearing mice.[61Cu]ATSM with high radiochemical purity (>99%, HPLC, RTLC) was injected to wild-type rats as well as hypoxic and necrotic fibrosarcoma-bearing mice followed by imaging up to 3 hours.[61Cu]ATSM was mainly accumulated in liver, as well as kidney and bladder and less but still significant in brain of wild-type rats. A significant and hypoxia-specific tumor/non tumor ratio in hypoxic models was observed by coincidence imaging 2 h post injection, while in necrotic and 12-week tumor-induced mice very slight tumor uptakes were detected. [61Cu]ATSM is a positron emission tomography (PET) radiotracer for selective tumor hypoxia imaging from necrotic and proliferative tumors. Keywords: [61Cu] ATSM, Hypoxia, Co-incidence imaging, Fibrosarcoma 71
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