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3rd International Congress 3rd International of Nuclear Congress Medicine of Nuclear & 15th Medicine Iranian Annual & 15th Iranian Congress Annual of Nuclear Congress Medicine of Nuclear Medicine Shahid Beheshti Shahid Beheshti University University of Medical Sciences of Medical 19-21 Sciences May 201119-21 May 2011 Research of exposure rate of urinary tract and gonads of nuclear medicine patients during kidney scan with Tc-99m-Ec with the use of TLD-100h and comparison with VMC method Navideh Aghaei Amirkhizi, Sepideh Hekmat, Elham Shahhoseini, Farhad Manouchehri, Mohaddeseh Naderi In kidney diseases that are reported widely in our country, in order to evaluation and diagnostic of physiological situation of kidney and bladder, nuclear medicine method is the first priority among other diagnostic methods. In this research, exposure rate of urinary tract and gonad of selected patients were measured in kidney scan with Tc-99m-Ec with the use of TLD-100h and skin surface doses were studied during imaging time. In general, skin surface doses were measured and the results were compared with Visual Mont Carlo(VMC) method. The final results show, skin and total dose have been lower than annual dose limits. Keywords: TLD, Urinary tract, VMC 172
3rd International Congress of of Nuclear Medicine & & 15th 15th Iranian Annual Annual Congress of Congress of Nuclear Medicine Shahid Beheshti Shahid Beheshti University University of Medical of Medical Sciences Sciences 19-21 19-21 May May 2011 The calculation of absorbed dose due to 131I-Chlorotoxin in liver using monte carlo method Rohollah Adeli, Seyed Pezhman Shirmardi, Mostafa Erfani (Gandomkar), Mohammad Ghannadi-Maragheh Nuclear Science & Technology Research Institute (NSTRI), Atomic Energy Organization of Iran Introduction: Chlorotoxin is a peptide derived from the venom of the scorpion Leiurus Quinquestriatus. It can bind with mmp2 receptors on glioma cells. In this research,we used Monte carlo method to calculate the absorbed dose in organ of interest.this method is a useful tool to transport of particles and absorbed dose calcululation. Methods: The peptide was synthesized by standard Fmoc solidphase synthesis on Rink amide MBHA resin with substitution of 0.69 mmol/g. Labeling of product was performed by chloramine-T method. Peptide (40 µg) was dissolved in PBS buffer (50 µl, 0.25 M, pH=7.5) then was added to a solution of 200 µci Na131I (in 0.1 N NaOH), followed by 50 µl chloramine-T (4 mg/ml in PBS 0.05 M, pH=7.5). For ex vivo counting mice were sacrificed after 1, 4 and 24 h and various organs were dissected, weighed and counted for radioactivity. The obtained data from organs was used in Monte Carlo method (MCNP code) to calculate the tissues dose according to MIRD principles. Results: Our results suggest that, this labeled chlorotoxin derivative might be useful in determining tumor extent and also tumor therapy of gliomas or possibly other cancers. The overall radiolabeling efficiency was about 80% at a specific activity of 0.740 GBq/mol. The liver of mouse was assumed as target organ. The sum of gamma and beta particles dose emitted by 131I were used to calculate total absorbed dose to liver. The results show that the delivered dose to liver was very small and 98% of total dose is due to beta particles. Conclusion: In this study, we have shown a synthetic approach toward preparation of a chemically and metabolically stable chlorotoxin derivative. Iodine-131 radiolabeling of these novel conjugate was performed in order to assess the most optimum conditions for radiolabeling and potential usage in clinical applications. We calculated the absorbed dose in liver using Monte Carlo method (MCNP code). Liver as a target organ absorbed very small dose as mentioned above. Keywords: Chlorotoxin 131I, Monte Carlo, Dosimetry, MIRD 173
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