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3rd International Congress 3rd International of Nuclear Congress Medicine of Nuclear & 15th Medicine Iranian Annual & 15th Iranian Congress Annual of Nuclear Congress Medicine of Nuclear Medicine Shahid Beheshti Shahid Beheshti University University of Medical Sciences of Medical 19-21 Sciences May 201119-21 May 2011 Different aspects of gated myocardial perfusion SPECT Vahid Reza Dabbagh Kakhki Nuclear Medicine Research Center, Mashhad University of Medical Sciences Myocardial single-photon emission computed tomography (SPECT) has been utilized as an important tool for optimal decision making in cardiology. Gated SPECT allows evaluation of myocardial perfusion imaging with subsequent analysis of regional wall motion and calculation of global & regional myocardial function. This integrated approach with simultaneous evaluation of myocardial perfusion and function, is clinically useful for the diagnosis, prognosis and follow-up of coronary artery disease. Available software algorithms for computation of left ventricular functional indices are: Quantitative Gated SPET (QGS, Cedars-Sinai Medical Center, Los Angeles, California, USA), Emory Cardiac Toolbox (ECTb, Emory University, Atlanta, Georgia, USA), 4D-MSPET (University of Michigan, Medical Center), layer of maximum counts (LMC), MultiDim (Sopha, Medical Vision International, Buc, France) and left ventricular global thickening fraction (LVGTF). Previous studies have compared these methods against cardiac magnetic resonance imaging (cMRI), echocardiography , gated blood pool SPET, contrast ventriculography ,and simulated images. Each of the above methods has its own advantages and drawbacks in estimating the left ventricular volumes (LVV) and left ventricular ejection fraction (LVEF) . It has also been reported that the calculated LVEF and LVV can be affected by different patient populations, imaging protocols, use of different isotopes, time to imaging after stress, differences in the image matrix, zoom, prereconstruction filtering, heart size, extent and severity of perfusion defects, etc. Keywords: Gated myocardial perfusion SPECT 58
3rd International Congress of of Nuclear Medicine & & 15th 15th Iranian Annual Annual Congress of Congress of Nuclear Medicine Shahid Beheshti Shahid Beheshti University University of Medical of Medical Sciences Sciences 19-21 19-21 May May 2011 The effect of Methimazole on Thyroid gland uptake of technetium in hyperthyroid patients Farshid Gheisari, Alireza Mehdizadeh, Mehrosadat Alavi Shiraz University of Medical Science, Nuclear Medicine Department Abstract: The aim of this study was to investigate the effect of Methimazole on Technetium-99mreabsorbing by thyroid gland, it may be possible to perform thyroid scan when the patients are on Methimazole, this can be time saving and decrease the adverse effect of discontinuing Methimazole. Patients and methods: Among all the patients with hyperthyroidism who referred to Nuclear medicine department of Shiraz University of Medical Sciences, 50 Patients were randomly selected, we asked the patients who were on Methimazole, to discontinue the usage of all other drugs and keep exact thyroid diet for one week, after that thyroid scan was performed again. Revealed data was analyzed under supervision of statistical specialist with descriptive method on SPSS. Results: 34 patients were male (86%) and other were female. Mean age of the patients was 53.5 years (39-75). Although the region of interest (ROI)of thyroid was increase4d in the patients who used Methimazole before scan 398.72(SD:191.73)than the patients who discontinued Methimazole one week before scan 380.15(SD:112.49), but the difference wasn’t statistically significant . The ROI of peripheral tissue of the thyroid was decreased in the patients who used Methimazole before scan 26.44(SD:5.57), but the difference wasn’t statistically significant . Discussion: we demonstrated that Methimazole pretreatment doesn’t interfere with either the efficacy of ROI and reabsorbing of Technetium-99m in thyroid gland and peripheral tissues. A possible limitation of this study is the number of patients in the sample. In conclusion, it may be possible to perform thyroid scan when the patients are on the Methimazole, this can be time saving and decrease the adverse effect of discontinuing Methimazole. Keywords: Methimazole , Technetium -99m, Hyperthyroidism 59
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