Panel Disdussion

3rd International Congress of of Nuclear Medicine & & 15th 15th Iranian Annual Annual Congress of
Congress of Nuclear Medicine
Shahid Beheshti Shahid Beheshti University University of Medical of Medical Sciences Sciences 19-21 19-21 May May 2011
Development of 166Ho-phytate complex for radiosynovectomy
Samaneh Zolghadri, Akbar Anvari, Amir Reza Jalilian, Hasan
Yousefnia, Ali Bahrami-Samani, Mohammad Ghannadi-Maragheh
Nuclear Science and Technology Research Institute
66Ho-chloride was obtained by bombardment of natural Ho(NO3)3,
dissolved in acidic media using thermal neutron flux (4-5 — 1013
n.cm-2.s-1). 166Ho-holmium chloride (185 MBq) was used for
preparation of 166Ho-phytate complex successfully with high
radiochemical purity (>99.9 %, ITLC, MeOH: H2O: acetic acid, 4: 4:
2, as mobile phase). The complex stability and viscosity were
checked in the final solution up to 2 days. The prepared complex
solution (60 µCi/100 µl) was injected intra-articularly to male rat
knee joint. Leakage of radioactivity from injection site and its
distribution in organs were investigated up to 2 days. Approximately,
all injected dose has remained in injection site 2days after injection.
The complex was proved to be a feasible agent for cavital
radiotherapy in oncology and rheumatology.
Keywords: phytate, radiosynovectomy, holmium-166,
biodistribution, SPECT
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