The obesogenic effects of polyunsaturated fatty acids are dependent ...

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FOOTNOTES This work was carried out as a part of the ‘DOCMAR’ research program funded by Innovation Norway and RUBIN. This work was supported by the Danish Natural Science Research Council, The Novo Nordisk Foundation, The Carlsberg Foundation and performed as part of the research program of the Danish Obesity Research Centre, supported by the Danish Council for Strategic Research, Grant 2101-06-0005. Financial support was also received from the University of Bergen, Program Committee on Nutrition, from the Eckbo Foundation and from the Norwegian Research Council, Grant 200515-I30. ACKNOWLEDGMENTS We thank Aase Heltveit and Lars Erik Pindard for help during the animal studies. We also thank Guro K. Christensen and Jacop Wessels for valuable technical assistance. FIGURE LEGENDS FIGURE 1. Elevated plasma bile acid concentration is an underlying factor for the increased energy expenditure and decreased adiposity elicited by salmon protein hydrolysate (SPH) feeding.(A-F) Male Wistar rats (n=6) were fed high-fat diets (45 kcal% fat) ad libitum for 46 days with either SPH or casein as the sole protein source. (A-B) SPH-fed rats had elevated plasma bile acids (BAs), whereas total liver BAs were unchanged. (C-E) The SPH-fed rats showed reduced body weight gain. Energy efficiency, calculated as bodyweight gain per energy intake, and white adipose tissue masses were reduced by SPH treatment. (F) Energy digestibility was equal in SPH and casein fed rats. (G-M) Three groups of rats (n=6) were pair-fed the SPH-diet, the casein diet and the SPHdiet with 0.5wt% cholestyramine (c’am). (G-I) Inclusion of cholestyramine to the SPH-diet attenuated the increase in plasma BA concentrations, without modulating liver total BAs or growth. (J) Inclusion of cholestyramine attenuated the reduction in body fat mass determined by dual-X ray absorptiometry (DEXA). (K-L) Three groups of rats (n=6) were pair-fed the SPH-diet, the casein diet and the SPHdiet with 0.5wt% cholestyramine (c’am) and energy expenditure was calculated by indirect calorimetry. Cholestyramine treatment attenuated the increase in O2 consumption, CO2 elimination and heat production. Data are presented as mean + S.E. Significant differences from casein-fed rats are denoted by * (P
FIGURE 3. Liver microarray analysis. Male Wistar rats (n=6) were fed high-fat diets (45 kcal% fat) ad libitum for 46 days with either SPH or casein as the sole protein source. RNA from individual rats was pooled within experimental groups, and the pooled samples were analyzed by Affymetrix arrays. (A) Data were analyzed and significantly altered KEGG pathways (P
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The obesogenic effects of polyunsat
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Table of Contents Acknowledgement .
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Abstract in Danish Polyumættede n-
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Polyunsaturated fatty acids in the
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was more than 3 times higher in the
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gluconeogenesis and ureagenesis (Fi
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high dietary PUFAs, the modulation
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In a pair of population studies, an
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18. Massiera, F. et al. Arachidonic
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54. Xu, J. et al. Polyunsaturated f
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Annexes 1. Ma T, Liaset B, Hao Q, P
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Fish Oil, Sucrose and Obesity Obesi
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Fish Oil, Sucrose and Obesity Figur
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Fish Oil, Sucrose and Obesity Table
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Fish Oil, Sucrose and Obesity 6. Ma
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Carbohydrate source and insulin sec
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20 21 22 23 24 25 26 27 28 29 30 31
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Page 80 and 81: Cyclooxygenases and UCP1 PLoS ONE |
Page 82 and 83: Cyclooxygenases and UCP1 E synthase
Page 84 and 85: Cyclooxygenases and UCP1 29. Granne
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Page 88 and 89: hydrolysate (SPH), would be protect
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Page 92 and 93: In order to demonstrate that bile a
Page 94 and 95: Nutritional regulation of endogenou
Page 96 and 97: in increased whole body energy expe
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Page 108 and 109: Figure 7 A Plasma ALAT B Liver Ucp2
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Page 112 and 113: Ruzzin et al. CD14, and rho kinases
Page 114 and 115: Ruzzin et al. salmon oil induced a
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