The obesogenic effects of polyunsaturated fatty acids are dependent ...

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Acknowledgement I am grateful to my supervisor Karsten Kristiansen for giving me the opportunity to continue my research life. It is full of excitement, as all I can ask for. Thanks to his guidance and inspiration. I would as well give my thanks to my co-supervisor Lise Madsen for conceiving, organizing and directing my project. That is precious experiences that I can benefit from for my future work. We can only be a part of a team in order to achieve. I would like to thanks all the group members in Denmark and Norway for their helps and joys they bring along, especially Qin Hao and Rasmus Koefoed Petersen for their patience and kindness. Also, my appreciation to Alison Keenan for her great help with the language. And finally, there is nothing can be accomplished without the continuous support and love from my family. 2
Table of Contents Acknowledgement ............................................................................................................................................. 2 Abstract ............................................................................................................................................................. 4 Abstract in Danish .............................................................................................................................................. 5 Introduction ....................................................................................................................................................... 6 Obesity and food intake ................................................................................................................................ 6 Polyunsaturated fatty acids in the diet ......................................................................................................... 7 Adipocyte biology .......................................................................................................................................... 7 Adipogenesis is dependent on cAMP levels. ................................................................................................. 8 Results ............................................................................................................................................................... 9 Discussion, perspectives .................................................................................................................................. 11 Low carbohydrate, high protein diet ........................................................................................................... 11 Branched-chain amino acids and mTOR ...................................................................................................... 12 Regulation of hepatic lipogenesis ................................................................................................................ 12 Fructose ....................................................................................................................................................... 13 Fish oil contaminants ................................................................................................................................... 14 References ....................................................................................................................................................... 16 Annexes ........................................................................................................................................................... 21 3
Page 1: The obesogenic effects of polyunsat
Page 5 and 6: Abstract in Danish Polyumættede n-
Page 7 and 8: Polyunsaturated fatty acids in the
Page 9 and 10: was more than 3 times higher in the
Page 11 and 12: gluconeogenesis and ureagenesis (Fi
Page 13 and 14: high dietary PUFAs, the modulation
Page 15 and 16: In a pair of population studies, an
Page 17 and 18: 18. Massiera, F. et al. Arachidonic
Page 19 and 20: 54. Xu, J. et al. Polyunsaturated f
Page 21 and 22: Annexes 1. Ma T, Liaset B, Hao Q, P
Page 23 and 24: Fish Oil, Sucrose and Obesity Obesi
Page 25 and 26: Fish Oil, Sucrose and Obesity Figur
Page 27 and 28: Fish Oil, Sucrose and Obesity Table
Page 33 and 34: Fish Oil, Sucrose and Obesity 6. Ma
Page 35 and 36: Carbohydrate source and insulin sec
Page 37 and 38: 20 21 22 23 24 25 26 27 28 29 30 31
Page 39 and 40: 68 69 70 71 72 73 74 75 76 77 78 79
Page 41 and 42: 114 115 116 117 118 119 120 121 122
Page 43 and 44: 160 161 162 163 164 165 166 167 168
Page 45 and 46: 208 209 210 211 212 213 214 215 216
Page 47 and 48: 256 257 258 259 260 261 262 263 264
Page 49 and 50: 302 303 304 305 306 307 308 309 310
Page 51 and 52: 350 351 FIGURE LEGENDS 352 353 354
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398 399 400 401 402 403 404 subunit
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446 447 448 449 450 451 gamma, coac
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484 485 486 TABLE 1. Macronutrient
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Energy (kJ/g) 17.16 25.12 25.12 25.
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561 562 563 564 565 566 567 568 569
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635 636 637 638 639 640 641 642 643
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711 712 713 714 715 716 717 718 719
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Cyclooxygenases and UCP1 Although i
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Cyclooxygenases and UCP1 Figure 2.
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Cyclooxygenases and UCP1 Figure 4.
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Cyclooxygenases and UCP1 PLoS ONE |
Page 82 and 83:
Cyclooxygenases and UCP1 E synthase
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Cyclooxygenases and UCP1 29. Granne
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JBC Papers in Press. Published on J
Page 88 and 89:
hydrolysate (SPH), would be protect
Page 90 and 91:
was used as the liver cytosolic fra
Page 92 and 93:
In order to demonstrate that bile a
Page 94 and 95:
Nutritional regulation of endogenou
Page 96 and 97:
in increased whole body energy expe
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38. Kanehisa M, and Goto S. (2000)
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FOOTNOTES This work was carried out
Page 102 and 103:
fed the same diets, plus the SPH-di
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Figure 2 A nmol/ min/ mg prot 2,4 1
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Figure 4 A 6 Liver Pparα B 21 Live
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Figure 7 A Plasma ALAT B Liver Ucp2
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Ruzzin et al. investigated the meta
Page 112 and 113:
Ruzzin et al. CD14, and rho kinases
Page 114 and 115:
Ruzzin et al. salmon oil induced a
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