The obesogenic effects of polyunsaturated fatty acids are dependent ...

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fed the same diets, plus the SPH-diet with 0.5wt% cholestyramine (c’am) for 46 days. Pharmacological removal of bile acids by 0.5 wt% cholestyramine attenuated the glucose lowering effect of SPH. Pck1 mRNA levels are normalized to General transcription factor IIB (Gtf2b). Data are presented as mean + S.E. Significant difference from casein-fed rats are denoted by * (P
Figure 1 A 30 Plasma BA ** B 1,5 Liver BAs SPH Casein C 300 Growth chart µmol/ L 20 10 0 SPH Casein µmol/ tissue 1,0 0,5 0,0 ** Gram BW 200 100 0 0 10 20 30 40 50 Days of feeding Casein SPH D Energy efficiency E Adipose tissue masses F Energy digestibility Gram BW/ MJ intake 21 14 7 0 ** SPH Casein g tissue 6 4 2 0 ** ** eWAT MeWAT iBAT SPH Casein % of ingested energy 96 64 32 0 SPH Casein G µmol/ L J Gram 54 36 18 0 90 60 30 0 Plasma BA ** SPH SPH + c'am Body fat ** SPH SPH + c'am Casein Casein H µmol/ tissue K Liter O2/ kg BW/ 24h 3 2 1 0 60 50 40 Liver total BAs SPH SPH + c'am O 2 consumed ** * SPH SPH + c'am Casein Casein I Gram BW L Liter CO2/ kg BW/ 24h 350 300 250 200 150 55 45 35 Growth chart 0 10 20 30 40 50 CO 2 eliminated ** * SPH SPH + c'am Days of feeding Casein M kJ/ 24h/ kg BW 0.75 780 720 660 600 SPH SPH + c'am Casein SPH SPH + c'am Heat production ** * Casein Downloaded from www.jbc.org by guest, on July 7, 2011 18
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The obesogenic effects of polyunsat
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Table of Contents Acknowledgement .
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Abstract in Danish Polyumættede n-
Page 7 and 8:
Polyunsaturated fatty acids in the
Page 9 and 10:
was more than 3 times higher in the
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gluconeogenesis and ureagenesis (Fi
Page 13 and 14:
high dietary PUFAs, the modulation
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In a pair of population studies, an
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18. Massiera, F. et al. Arachidonic
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54. Xu, J. et al. Polyunsaturated f
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Annexes 1. Ma T, Liaset B, Hao Q, P
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Fish Oil, Sucrose and Obesity Obesi
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Fish Oil, Sucrose and Obesity Figur
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Fish Oil, Sucrose and Obesity Table
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Page 31 and 32:
Page 33 and 34:
Fish Oil, Sucrose and Obesity 6. Ma
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Carbohydrate source and insulin sec
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20 21 22 23 24 25 26 27 28 29 30 31
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68 69 70 71 72 73 74 75 76 77 78 79
Page 41 and 42:
114 115 116 117 118 119 120 121 122
Page 43 and 44:
160 161 162 163 164 165 166 167 168
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208 209 210 211 212 213 214 215 216
Page 47 and 48:
256 257 258 259 260 261 262 263 264
Page 49 and 50:
302 303 304 305 306 307 308 309 310
Page 51 and 52: 350 351 FIGURE LEGENDS 352 353 354
Page 53 and 54: 398 399 400 401 402 403 404 subunit
Page 55 and 56: 446 447 448 449 450 451 gamma, coac
Page 57 and 58: 484 485 486 TABLE 1. Macronutrient
Page 59 and 60: Energy (kJ/g) 17.16 25.12 25.12 25.
Page 61 and 62: 561 562 563 564 565 566 567 568 569
Page 63 and 64: 635 636 637 638 639 640 641 642 643
Page 65: 711 712 713 714 715 716 717 718 719
Page 74 and 75: Cyclooxygenases and UCP1 Although i
Page 76 and 77: Cyclooxygenases and UCP1 Figure 2.
Page 78 and 79: Cyclooxygenases and UCP1 Figure 4.
Page 80 and 81: Cyclooxygenases and UCP1 PLoS ONE |
Page 82 and 83: Cyclooxygenases and UCP1 E synthase
Page 84 and 85: Cyclooxygenases and UCP1 29. Granne
Page 86 and 87: JBC Papers in Press. Published on J
Page 88 and 89: hydrolysate (SPH), would be protect
Page 90 and 91: was used as the liver cytosolic fra
Page 92 and 93: In order to demonstrate that bile a
Page 94 and 95: Nutritional regulation of endogenou
Page 96 and 97: in increased whole body energy expe
Page 98 and 99: 38. Kanehisa M, and Goto S. (2000)
Page 100 and 101: FOOTNOTES This work was carried out
Page 104 and 105: Figure 2 A nmol/ min/ mg prot 2,4 1
Page 106 and 107: Figure 4 A 6 Liver Pparα B 21 Live
Page 108 and 109: Figure 7 A Plasma ALAT B Liver Ucp2
Page 110 and 111: Ruzzin et al. investigated the meta
Page 112 and 113: Ruzzin et al. CD14, and rho kinases
Page 114 and 115: Ruzzin et al. salmon oil induced a
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