The obesogenic effects of polyunsaturated fatty acids are dependent ...
The obesogenic effects of polyunsaturated fatty acids are dependent ...
The obesogenic effects of polyunsaturated fatty acids are dependent ...
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Figure 2<br />
A<br />
nmol/ min/ mg prot<br />
2,4<br />
1,6<br />
0,8<br />
iBAT Palm-CoA ox<br />
*<br />
B<br />
Ucp1/ Gtf2b<br />
360<br />
240<br />
120<br />
iBAT Ucp1<br />
**<br />
C<br />
Dio2/ Gtf2b<br />
6<br />
4<br />
2<br />
iBAT Dio2<br />
*<br />
D<br />
Pgc-1α/ Gtf2b<br />
3,9<br />
2,6<br />
1,3<br />
iBAT Pgc-1α<br />
0,0<br />
SPH<br />
Casein<br />
0<br />
SPH<br />
Casein<br />
0<br />
SPH<br />
Casein<br />
0,0<br />
SPH<br />
Casein<br />
E<br />
Relative to casein<br />
3,6<br />
2,4<br />
1,2<br />
0<br />
**<br />
WAT Ucp1<br />
iWAT eWAT MeWAT<br />
F<br />
Relative to casein<br />
7,5<br />
5,0<br />
2,5<br />
0,0<br />
WAT Dio2<br />
*<br />
*<br />
*<br />
iWAT eWAT MeWAT<br />
G<br />
Relative to casein<br />
2,4<br />
1,6<br />
0,8<br />
0<br />
WAT Pgc-1α<br />
* *<br />
iWAT eWAT MeWAT<br />
SPH<br />
Casein<br />
SPH<br />
Casein<br />
SPH<br />
Casein<br />
H<br />
Gram<br />
K<br />
30<br />
20<br />
10<br />
0<br />
Abdominal fat<br />
**<br />
SPH SPH +<br />
c'am<br />
Casein<br />
I<br />
Relative to casein<br />
eWAT Palm-CoA ox<br />
1,4<br />
1,2<br />
1,0<br />
0,8<br />
SPH SPH +<br />
c'am<br />
eWAT adipocyte cell size<br />
SPH SPH + c'am Casein<br />
Casein<br />
J<br />
Rel expression<br />
9<br />
6<br />
3<br />
0<br />
L<br />
eWAT gene-expression<br />
Ucp1 Dio2 Pgc-1a<br />
Relative to control<br />
1,8<br />
1,2<br />
0,6<br />
0<br />
In vitro adipocyte Palm-CoA<br />
oxidation<br />
SPH<br />
SPH + c'am<br />
Casein<br />
* ** *<br />
0 25 75 200<br />
Taurocholic acid, µmol/L<br />
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