First 11 pages of thesis. - OPUS - Universität Würzburg

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implications in intracellular fluorescence detection of superoxide. Free Radic Biol Med. Jun 1 2003;34(11):1359-1368. 200. Qu XW, Wang H, De Plaen IG, Rozenfeld RA, Hsueh W. Neuronal nitric oxide synthase (NOS) regulates the expression of inducible NOS in rat small intestine via modulation of nuclear factor kappa B. Faseb J. Feb 2001;15(2):439-446. 201. Kinugawa S, Huang H, Wang Z, Kaminski PM, Wolin MS, Hintze TH. A defect of neuronal nitric oxide synthase increases xanthine oxidase-derived superoxide anion and attenuates the control of myocardial oxygen consumption by nitric oxide derived from endothelial nitric oxide synthase. Circ Res. Feb 18 2005;96(3):355-362. 202. Boissel JP, Bros M, Schrock A, Godtel-Armbrust U, Forstermann U. Cyclic AMP-mediated upregulation of the expression of neuronal NO synthase in human A673 neuroepithelioma cells results in a decrease in the level of bioactive NO production: analysis of the signaling mechanisms that are involved. Biochemistry. Jun 8 2004;43(22):7197-7206. 203. Shang T, Kotamraju S, Zhao H, Kalivendi SV, Hillard CJ, Kalyanaraman B. Sepiapterin attenuates 1-methyl-4-phenylpyridinium-induced apoptosis in neuroblastoma cells transfected with neuronal NOS: role of tetrahydrobiopterin, nitric oxide, and proteasome activation. Free radical biology & medicine. Oct 15 2005;39(8):1059-1074. 204. Hallemeesch MM, Janssen BJ, de Jonge WJ, Soeters PB, Lamers WH, Deutz NE. NO production by cNOS and iNOS reflects blood pressure changes in LPS-challenged mice. Am J Physiol Endocrinol Metab. Oct 2003;285(4):E871-875. 205. Minor RL, Jr., Myers PR, Guerra R, Jr., Bates JN, Harrison DG. Dietinduced atherosclerosis increases the release of nitrogen oxides from rabbit aorta. J Clin Invest. Dec 1990;86(6):2109-2116. 206. Hattori Y, Hattori S, Wang X, Satoh H, Nakanishi N, Kasai K. Oral administration of tetrahydrobiopterin slows the progression of atherosclerosis in apolipoprotein E-knockout mice. Arteriosclerosis, thrombosis, and vascular biology. Apr 2007;27(4):865-870. 207. Laursen JB, Somers M, Kurz S, McCann L, Warnholtz A, Freeman BA, Tarpey M, Fukai T, Harrison DG. Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin. Circulation. Mar 6 2001;103(9):1282-1288. 208. Sun J, Druhan LJ, Zweier JL. Dose dependent effects of reactive oxygen and nitrogen species on the function of neuronal nitric oxide synthase. Arch Biochem Biophys. Mar 15 2008;471(2):126-133. 209. Ginnan R, Guikema BJ, Halligan KE, Singer HA, Jourd'heuil D. Regulation of smooth muscle by inducible nitric oxide synthase and NADPH oxidase in vascular proliferative diseases. Free radical biology & medicine. Apr 1 2008;44(7):1232-1245. 210. Pleskova M, Beck KF, Behrens MH, Huwiler A, Fichtlscherer B, Wingerter O, Brandes RP, Mulsch A, Pfeilschifter J. Nitric oxide down-regulates the expression of the catalytic NADPH oxidase subunit Nox1 in rat renal mesangial cells. Faseb J. Jan 2006;20(1):139-141. 211. Kaur J, Dhaunsi GS, Turner RB. Interleukin-1 and nitric oxide increase NADPH oxidase activity in human coronary artery smooth muscle cells. Med Princ Pract. Jan-Feb 2004;13(1):26-29. - 94 -
Apo E : Apolipoprotein E BH4 : Tetrahydrobiopterin CAD : Coronary artery disease Abbreviations DETC : Diethyldithiocarbamic acid ESR : Electron spin resonance KHB : Krebs Hepes Buffer L-NAME : L-arginine methyl ester LDL : Low density lipoprotein HDL : High density lipoprotein HPLC : High Performance Liquid Chromatography N-AANG :N-[(4S)-4-amino-5-[(2-aminoethyl) amino] pentyl]-N'- nitroguanidine tris (trifluoroacetate) NADPH : Nicotinamide adenine dinucleotide phosphate NHIS 95 : National Health Interview Survey 1995 NO : Nitric oxide NOS : Nitric oxide synthase Ox-LDL : Oxidized LDL TNF-α : Tumor necrosis factor- α 1400W : N-(3-aminomethyl) benzyl-acetamidine - 95 -
Page 1 and 2:
Insight into oxidative stress media
Page 3 and 4:
Eidesstattliche Erklärungen Hiermi
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Acknowledgements First and foremost
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“Research is to see what everybod
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Chapter 2 37 2.0 Materials and Meth
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Summary and Hypothesis 76 Zusammenf
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1.0 Introduction Atherosclerosis, t
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which contribute to the lipid rich
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1.2 Risk Factors Atherosclerosis ha
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1.2.2 Environmental factors 1. High
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1.3 Oxidative Stress Oxidative stre
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peroxynitrite 38 which by itself ca
Page 26 and 27:
Pharmacological inhibition of nitri
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1.4 The nitric oxide pathway in ath
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of NADPH, FAD and FMN, whereas the
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isoforms to the regulatory and targ
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perinuclear/golgi region within the
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nNOS interacts with several protein
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iNOS expression is regulated transc
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transport pathway and is an essenti
Page 42 and 43:
Interestingly, BH4 supplementation
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the survival rate, as apoE/nNOS dko
Page 46 and 47:
The seemingly opposing effects of i
Page 48 and 49:
The purpose of the study presented
Page 50 and 51:
2.0 Materials and Methods 2.1 Mater
Page 52 and 53:
Reagents Source For Immunohistochem
Page 54 and 55:
Others Reagents Source Pegulated Su
Page 56 and 57: 2.2 Methods 2.2.1 Detection of free
Page 58 and 59: 2.2.1.2 Principle of ESR ESR spectr
Page 60 and 61: spectra 190 . Addition of exogenous
Page 62 and 63: ings were prepared as mentioned abo
Page 64 and 65: X-band EMX spectroscope (Bruker Bio
Page 66 and 67: minutes. At last sections were wash
Page 68 and 69: 3.0 Results 3.1 eNOS is a significa
Page 70 and 71: 3.2 eNOS deletion decreases vascula
Page 72 and 73: 3.3 nNOS contributes little to vasc
Page 74 and 75: 3.5 iNOS contributes significantly
Page 76 and 77: Figure 13. Determination of iNOS de
Page 78 and 79: 3.8 iNOS deletion influences NADPH
Page 80 and 81: 4.0 Discussion 4.1 eNOS is a major
Page 82 and 83: in our apoE/eNOS dko model, these a
Page 84 and 85: under conditions of substrate or co
Page 86 and 87: vessels with the iNOS specific inhi
Page 88 and 89: Summary and Hypothesis The principl
Page 90 and 91: Zusammenfassung und Hypothese Stick
Page 92 and 93: Bibliography 1. Gimbrone MA, Jr. Va
Page 94 and 95: xanthine oxidase contributes to vas
Page 96 and 97: expression of adhesion molecules an
Page 98 and 99: transforming growth factor-beta 1.
Page 100 and 101: generation from neuronal nitric oxi
Page 102 and 103: 148. Lee PC, Wang ZL, Qian S, Watki
Page 104 and 105: 174. Mayr U, Zou Y, Zhang Z, Dietri
Page 108 and 109: Definitions Thesaurus • Allograft
Page 110 and 111: • Claudication refers to leg pain
Page 112 and 113: cases per year in the US. It is a n
Page 114 and 115: Curriculum Curriculum vitae vitae N
Page 116 and 117: presentation at the 37 th Annual co
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First 11 pages of thesis. - OPUS - Universität Würzburg

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