First 11 pages of thesis. - OPUS - Universität Würzburg
First 11 pages of thesis. - OPUS - Universität Würzburg
First 11 pages of thesis. - OPUS - Universität Würzburg
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
Contents<br />
Chapter 1 1<br />
1.0 Introduction 2<br />
1.1 Pathogenesis <strong>of</strong> atherosclerosis 2<br />
1.2 Risk factors 6<br />
1.2.1 Factors with a strong genetic component 6<br />
1.2.2 Environmental factors 8<br />
1.3 Oxidative stress 10<br />
1.3.1 Sources <strong>of</strong> oxidants in the vasculature <strong>11</strong><br />
1.3.2 Functional role <strong>of</strong> superoxide in atherosclerosis 12<br />
1.3.3 Functional role <strong>of</strong> nitric oxide in atherosclerosis 13<br />
1.4 The nitric oxide pathway in atherosclerosis 16<br />
1.4.1 Overview <strong>of</strong> NOS family 17<br />
1.4.2 Unique features <strong>of</strong> NOS is<strong>of</strong>orms 19<br />
1.4.2.1 Endothelial nitric oxide synthase (eNOS) 20<br />
1.4.2.2 Neuronal nitric oxide synthase (nNOS) 22<br />
1.4.2.3 Inducible nitric oxide synthase (iNOS) 25<br />
1.5 The apoE ko model <strong>of</strong> atherosclerosis 27<br />
1.6 Role <strong>of</strong> NOS is<strong>of</strong>orms in cardiovascular diseases 28<br />
1.6.1 Role <strong>of</strong> eNOS in cardiovascular diseases 28<br />
1.6.2 Role <strong>of</strong> nNOS in cardiovascular diseases 30<br />
1.6.3 Role <strong>of</strong> iNOS in cardiovascular diseases 32<br />
1.7 Aim <strong>of</strong> the study 35<br />
ix
Change language