First 11 pages of thesis. - OPUS - Universität Würzburg

Chapter 3 55
3.0 Results 56
3.1 eNOS is a significant source of vascular wall nitric oxide
production and circulating nitric oxide 56
3.2 eNOS deletion decreases vascular production of superoxide
in apoE ko vessels 58
3.3 nNOS contributes little to vascular nitric oxide production 60
3.4 Contribution of nNOS to vascular superoxide production in
apoE ko animals 61
3.5 iNOS contributes significantly to vascular nitric oxide production 62
3.6 iNOS plays a major role in vascular superoxide production 63
3.7 Nitric oxide and superoxide generation from iNOS results in
peroxynitrite formation 65
3.8 iNOS deletion influences NADPH oxidase mediated superoxide
production 66
Chapter 4 67
4.0 Discussion 68
4.1 eNOS is a major contributor of nitric oxide and superoxide
generation in apoE ko vessels 68
4.2 Vascular nNOS generates low amounts of nitric oxide and
superoxide 70
4.3 iNOS generates nitric oxide and superoxide simultaneously in
apoE ko vessels 72
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