First 11 pages of thesis. - OPUS - Universität Würzburg
First 11 pages of thesis. - OPUS - Universität Würzburg
First 11 pages of thesis. - OPUS - Universität Würzburg
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Figure 13. Determination <strong>of</strong> iNOS derived superoxide production: a) Superoxide levels<br />
were significantly lower in apoE/iNOS dko animals, compared to apoE ko controls (ESR<br />
measurements <strong>of</strong> SOD inhibitable CM . signal (**p≤0.01)). b) Additionally, HPLC measurements<br />
revealed that iNOS deletion reduced vascular superoxide production in apoE ko animals. ApoE<br />
ko had significantly higher vascular superoxide levels than C57Bl6 animals (*p≤0.01,<br />
**p≤0.0001). c) Acute inhibition <strong>of</strong> iNOS in vessels <strong>of</strong> apoE ko mice, using iNOS specific inhibitor<br />
1400W, significantly reduced superoxide production ( § p≤0.0001).<br />
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