First 11 pages of thesis. - OPUS - Universität Würzburg

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Definitions Thesaurus • Allograft / vein graft arteriosclerosis refers to arteriosclerosis developed following tissue or vein graft transplantation. An allograft or homograft is a transplant in which transplanted cells, tissues, or organs are sourced from a genetically non-identical member of the same species. Most human tissue and organ transplants are allografts. • Angina pectoris, commonly known as angina, is chest pain due to ischemia of the heart muscle, generally due to obstruction or spasm of the coronary arteries (the heart's blood vessels). Coronary artery disease, the main cause of angina, is due to atherosclerosis of the cardiac arteries. • Aortic aneurysm is a general term for any swelling of the aorta, usually representing an underlying weakness in the wall of the aorta. While the stretched vessel may occasionally cause discomfort, a greater concern is the risk of rupture which causes severe pain; massive internal bleeding and without prompt treatment results in quick death. • Aortic dissection is a tear in the wall of the aorta that causes blood to flow between the layers of the wall of the aorta and force the layers apart. Aortic dissection is a medical emergency and can quickly lead to death, even with optimal treatment. - 96 -
• Balloon angioplasty is a widely used catheter-based technique for opening blocked arteries and treating coronary artery disease (CAD) and is one of the standard treatments for CAD. To restore normal blood flow, a balloon-tipped catheter is guided into one of the clogged arteries, and the balloon is rapidly inflated. This action helps blood flow more freely through the vessel by pushing the plaque back against the artery wall, creating small cracks or fissures called plaque fractures within the brittle, fatty deposit and by stretching the artery. • Cardiac hypertrophy is a thickening of the heart muscle (myocardium) which results in a decrease in size of the chamber of the heart, including the left and right ventricles. • Cardiomyopathy is the deterioration of the function of the myocardium (i.e., the heart muscle) for any reason. People with cardiomyopathy are often at risk of sudden cardiac death. • Carotid artery ligation model is an animal model that is used to study arterial injuries. The carotid artery is ligated using a wire, to cause denudation of the endothelium, representing vascular injury during angioplasty. • Caveolae (Latin for little caves) are small (50–100 nanometer) invaginations of the plasma membrane in many vertebrate cell types, especially in endothelial cells and adipocytes. - 97 -
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Insight into oxidative stress media
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Eidesstattliche Erklärungen Hiermi
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Acknowledgements First and foremost
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“Research is to see what everybod
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Chapter 2 37 2.0 Materials and Meth
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Summary and Hypothesis 76 Zusammenf
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1.0 Introduction Atherosclerosis, t
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which contribute to the lipid rich
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1.2 Risk Factors Atherosclerosis ha
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1.2.2 Environmental factors 1. High
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1.3 Oxidative Stress Oxidative stre
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peroxynitrite 38 which by itself ca
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Pharmacological inhibition of nitri
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1.4 The nitric oxide pathway in ath
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of NADPH, FAD and FMN, whereas the
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isoforms to the regulatory and targ
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perinuclear/golgi region within the
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nNOS interacts with several protein
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iNOS expression is regulated transc
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transport pathway and is an essenti
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Interestingly, BH4 supplementation
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the survival rate, as apoE/nNOS dko
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The seemingly opposing effects of i
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The purpose of the study presented
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2.0 Materials and Methods 2.1 Mater
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Reagents Source For Immunohistochem
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Others Reagents Source Pegulated Su
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2.2 Methods 2.2.1 Detection of free
Page 58 and 59: 2.2.1.2 Principle of ESR ESR spectr
Page 60 and 61: spectra 190 . Addition of exogenous
Page 62 and 63: ings were prepared as mentioned abo
Page 64 and 65: X-band EMX spectroscope (Bruker Bio
Page 66 and 67: minutes. At last sections were wash
Page 68 and 69: 3.0 Results 3.1 eNOS is a significa
Page 70 and 71: 3.2 eNOS deletion decreases vascula
Page 72 and 73: 3.3 nNOS contributes little to vasc
Page 74 and 75: 3.5 iNOS contributes significantly
Page 76 and 77: Figure 13. Determination of iNOS de
Page 78 and 79: 3.8 iNOS deletion influences NADPH
Page 80 and 81: 4.0 Discussion 4.1 eNOS is a major
Page 82 and 83: in our apoE/eNOS dko model, these a
Page 84 and 85: under conditions of substrate or co
Page 86 and 87: vessels with the iNOS specific inhi
Page 88 and 89: Summary and Hypothesis The principl
Page 90 and 91: Zusammenfassung und Hypothese Stick
Page 92 and 93: Bibliography 1. Gimbrone MA, Jr. Va
Page 94 and 95: xanthine oxidase contributes to vas
Page 96 and 97: expression of adhesion molecules an
Page 98 and 99: transforming growth factor-beta 1.
Page 100 and 101: generation from neuronal nitric oxi
Page 102 and 103: 148. Lee PC, Wang ZL, Qian S, Watki
Page 104 and 105: 174. Mayr U, Zou Y, Zhang Z, Dietri
Page 106 and 107: implications in intracellular fluor
Page 110 and 111: • Claudication refers to leg pain
Page 112 and 113: cases per year in the US. It is a n
Page 114 and 115: Curriculum Curriculum vitae vitae N
Page 116 and 117: presentation at the 37 th Annual co
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First 11 pages of thesis. - OPUS - Universität Würzburg

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