- Page 1 and 2: Insight into oxidative stress media
- Page 3 and 4: Eidesstattliche Erklärungen Hiermi
- Page 6 and 7: Acknowledgements First and foremost
- Page 8 and 9: “Research is to see what everybod
- Page 10 and 11: Chapter 2 37 2.0 Materials and Meth
- Page 14 and 15: 1.0 Introduction Atherosclerosis, t
- Page 16 and 17: which contribute to the lipid rich
- Page 18 and 19: 1.2 Risk Factors Atherosclerosis ha
- Page 20 and 21: 1.2.2 Environmental factors 1. High
- Page 22 and 23: 1.3 Oxidative Stress Oxidative stre
- Page 24 and 25: peroxynitrite 38 which by itself ca
- Page 26 and 27: Pharmacological inhibition of nitri
- Page 28 and 29: 1.4 The nitric oxide pathway in ath
- Page 30 and 31: of NADPH, FAD and FMN, whereas the
- Page 32 and 33: isoforms to the regulatory and targ
- Page 34 and 35: perinuclear/golgi region within the
- Page 36 and 37: nNOS interacts with several protein
- Page 38 and 39: iNOS expression is regulated transc
- Page 40 and 41: transport pathway and is an essenti
- Page 42 and 43: Interestingly, BH4 supplementation
- Page 44 and 45: the survival rate, as apoE/nNOS dko
- Page 46 and 47: The seemingly opposing effects of i
- Page 48 and 49: The purpose of the study presented
- Page 50 and 51: 2.0 Materials and Methods 2.1 Mater
- Page 52 and 53: Reagents Source For Immunohistochem
- Page 54 and 55: Others Reagents Source Pegulated Su
- Page 56 and 57: 2.2 Methods 2.2.1 Detection of free
- Page 58 and 59: 2.2.1.2 Principle of ESR ESR spectr
- Page 60 and 61: spectra 190 . Addition of exogenous
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ings were prepared as mentioned abo
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X-band EMX spectroscope (Bruker Bio
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minutes. At last sections were wash
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3.0 Results 3.1 eNOS is a significa
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3.2 eNOS deletion decreases vascula
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3.3 nNOS contributes little to vasc
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3.5 iNOS contributes significantly
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Figure 13. Determination of iNOS de
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3.8 iNOS deletion influences NADPH
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4.0 Discussion 4.1 eNOS is a major
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in our apoE/eNOS dko model, these a
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under conditions of substrate or co
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vessels with the iNOS specific inhi
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Summary and Hypothesis The principl
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Zusammenfassung und Hypothese Stick
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Bibliography 1. Gimbrone MA, Jr. Va
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xanthine oxidase contributes to vas
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expression of adhesion molecules an
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transforming growth factor-beta 1.
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generation from neuronal nitric oxi
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148. Lee PC, Wang ZL, Qian S, Watki
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174. Mayr U, Zou Y, Zhang Z, Dietri
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implications in intracellular fluor
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Definitions Thesaurus • Allograft
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• Claudication refers to leg pain
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cases per year in the US. It is a n
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Curriculum Curriculum vitae vitae N
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presentation at the 37 th Annual co