First 11 pages of thesis. - OPUS - Universität Würzburg

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cases per year in the US. It is a neuroendocrine tumor, arising from any neural crest element of the sympathetic nervous system. • Nitrergic nerves: Nerve where transmission is mediated by nitric oxide. • Non-adrenergic non-cholinergic neuron usually refers to autonomic efferent neuron whose transmission is not blocked by blocking adrenergic (catecholamines) and cholinergic (acetylcholine) transmission. Nitric oxide may be the transmitter in some cases. • Protein kinase G (PKG) is a serine/threonine-specific protein kinase that is activated by cGMP. It phosphorylates a number of biologically important targets and is implicated in the regulation of smooth muscle relaxation, platelet function, sperm metabolism, cell division and nucleic acid synthesis. • Reperfusion injury refers to damage to tissue caused when blood supply returns to the tissue after a period of ischemia. The absence of oxygen and nutrients from blood creates a condition in which the restoration of circulation results in inflammation and oxidative damage through the induction of oxidative stress rather than restoration of normal function. • Restenosis literally means the reoccurrence of stenosis. This is usually restenosis of an artery, or other blood vessel that has been "unblocked" by mechanically widening a narrowed or totally obstructed blood vessel (as a result of atherosclerosis) using interventional techniques like angioplasty. - 100 -
• Sepsis is a serious medical condition characterized by a whole-body inflammatory state caused by infection. Sepsis is broadly defined as the presence of various pus-forming and other pathogenic organisms, or their toxins, in the blood or tissues. • Soluble guanylate cyclase (sGC, (EC 4.6.1.2), also known as guanylyl cyclase or GC) is a lyase enzyme. It catalyzes the conversion of guanosine triphosphate (GTP) to 3',5'-cyclic guanosine monophosphate (cGMP) and pyrophosphate. sGC is a receptor for NO (thus also called NO receptor). It is soluble i.e. completely intracellular. It is most notably involved in vasodilation. • Transplant arteriosclerosis develops following organ transplantation. • Vasodilator is a drug or chemical that relaxes the smooth muscle in blood vessels, which causes them to dilate. - 101 -
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Insight into oxidative stress media
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Eidesstattliche Erklärungen Hiermi
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Acknowledgements First and foremost
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“Research is to see what everybod
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Chapter 2 37 2.0 Materials and Meth
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Summary and Hypothesis 76 Zusammenf
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1.0 Introduction Atherosclerosis, t
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which contribute to the lipid rich
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1.2 Risk Factors Atherosclerosis ha
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1.2.2 Environmental factors 1. High
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1.3 Oxidative Stress Oxidative stre
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peroxynitrite 38 which by itself ca
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Pharmacological inhibition of nitri
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1.4 The nitric oxide pathway in ath
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of NADPH, FAD and FMN, whereas the
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isoforms to the regulatory and targ
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perinuclear/golgi region within the
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nNOS interacts with several protein
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iNOS expression is regulated transc
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transport pathway and is an essenti
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Interestingly, BH4 supplementation
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the survival rate, as apoE/nNOS dko
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The seemingly opposing effects of i
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The purpose of the study presented
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2.0 Materials and Methods 2.1 Mater
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Reagents Source For Immunohistochem
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Others Reagents Source Pegulated Su
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2.2 Methods 2.2.1 Detection of free
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2.2.1.2 Principle of ESR ESR spectr
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spectra 190 . Addition of exogenous
Page 62 and 63: ings were prepared as mentioned abo
Page 64 and 65: X-band EMX spectroscope (Bruker Bio
Page 66 and 67: minutes. At last sections were wash
Page 68 and 69: 3.0 Results 3.1 eNOS is a significa
Page 70 and 71: 3.2 eNOS deletion decreases vascula
Page 72 and 73: 3.3 nNOS contributes little to vasc
Page 74 and 75: 3.5 iNOS contributes significantly
Page 76 and 77: Figure 13. Determination of iNOS de
Page 78 and 79: 3.8 iNOS deletion influences NADPH
Page 80 and 81: 4.0 Discussion 4.1 eNOS is a major
Page 82 and 83: in our apoE/eNOS dko model, these a
Page 84 and 85: under conditions of substrate or co
Page 86 and 87: vessels with the iNOS specific inhi
Page 88 and 89: Summary and Hypothesis The principl
Page 90 and 91: Zusammenfassung und Hypothese Stick
Page 92 and 93: Bibliography 1. Gimbrone MA, Jr. Va
Page 94 and 95: xanthine oxidase contributes to vas
Page 96 and 97: expression of adhesion molecules an
Page 98 and 99: transforming growth factor-beta 1.
Page 100 and 101: generation from neuronal nitric oxi
Page 102 and 103: 148. Lee PC, Wang ZL, Qian S, Watki
Page 104 and 105: 174. Mayr U, Zou Y, Zhang Z, Dietri
Page 106 and 107: implications in intracellular fluor
Page 108 and 109: Definitions Thesaurus • Allograft
Page 110 and 111: • Claudication refers to leg pain
Page 114 and 115: Curriculum Curriculum vitae vitae N
Page 116 and 117: presentation at the 37 th Annual co
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First 11 pages of thesis. - OPUS - Universität Würzburg

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