First 11 pages of thesis. - OPUS - Universität Würzburg

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Acknowledgements First and foremost I would like to thank Dr. Peter Kuhlencordt for his scientific guidance and moral support. I am indebted to him for being there for me at time of utmost need. He had been very patient and understanding and had not only tolerated my failures but had also helped me overcome my frustrations, by his pep talks. He had been the source of my inspiration and motivation as a researcher and had also nurtured me into the researcher that I am today. I sincerely thank him for giving me the liberty and encouragement to make crucial decisions. I really appreciate his constructive critical comments and the brainstorming discussions/”debates” which eventually led to my progress. His amazing capability to quote citations had been highly admirable. In addition to being my project supervisor, he had also taken personal care and helped me acclimatise in Germany. In addition to research, I had also learned a lot from him to deal people diplomatically and suavely. Without his kindness, care and understanding it would have been tough to have completed this work against all the odds. I would always remember him for his smartness and sweetness, which has made my doctoral thesis work an enjoyable experience. In short, it had been a great pleasure and fun working with him. I would like to thank Prof. Georg Ertl for giving me the opportunity to perform my thesis in his reputed institute. I really appreciate his simplicity and amicability. I also extend my sincere thanks to Prof. Roland Benz for taking time to look into the progress of my project and his useful suggestions during our discussions. Many thanks to Dr.Fink (Noxygen Science Transfer & Diagnostics, GmbH) for his ‘online’ guidance and helping me establish the ESR and HPLC techniques in the lab. His generous help and expertise had aided me in standardising these techniques. I would also like to thank Dr. Andreas Kamlowski (Brukers Biospin GmbH) for his co-operation in establishing the ESR technique in the lab and many thanks to IZKF (Interdisziplinären Zentrum für Klinische Forschung) for the financial support. I am thankful to my colleagues Gabriele Riehl and Alla Ganscher, who had helped me in many ways and for their kindness and care. They had taken personal care of me and had always wished for my well-being. I am grateful to Gabriele for having taken immense responsibility in taking care of all my animals. I greatly appreciate Alla for her patience in helping me learn German and for having tolerated my poor German!! I sincerely thank my other lab mates, Johannes Schödle, Sebastian Rützel, Eva Ostermeier, Angelika Schröttle, Elisabeth Bendel, Nadja Miller and Carolin Knoll and institute members especially Lisa Bauer and Helga Wagner for all their timely help and for creating a good working atmosphere. I am thankful to Elisabeth and Nadja for their help in German vi
translations. Special thanks to my lab mate Eva Ostermeier for her great experimental assistance, team spirit and co-operation in completing the project. I am very thankful to all of my Indian friends who had helped me in all possible ways and for creating a home away from home ambience. My special thanks to Reena, Shruti and Tripat for their friendship and for being patient listeners of all my stories. And of course, last but not the least, I would like to thank my family for their constant motivation. I am indebted to my dad- my best friend, philosopher and guide for his encouragement through out my childhood, till date and forever and for believing more in me than what I believe in myself. I hope to live up to his dreams! Many thanks to my mom, whose prayers have always been with me and for her moral support. My mom and dad had been the best parents a kid could ever hope for! Tons of thanks to my sisters- Thara and Sasi, for their motherly care, priceless love, affection and encouragement. I also thank my nephews, Sriram and Sanath for being my future. I have no words to express my gratitude to my family. Though miles away, their warmth, love and care had always kindled my happiness. Most of all, I thank my God father for being with me always, in thoughts. vii
Page 1 and 2: Insight into oxidative stress media
Page 3 and 4: Eidesstattliche Erklärungen Hiermi
Page 8 and 9: “Research is to see what everybod
Page 10 and 11: Chapter 2 37 2.0 Materials and Meth
Page 12 and 13: Summary and Hypothesis 76 Zusammenf
Page 14 and 15: 1.0 Introduction Atherosclerosis, t
Page 16 and 17: which contribute to the lipid rich
Page 18 and 19: 1.2 Risk Factors Atherosclerosis ha
Page 20 and 21: 1.2.2 Environmental factors 1. High
Page 22 and 23: 1.3 Oxidative Stress Oxidative stre
Page 24 and 25: peroxynitrite 38 which by itself ca
Page 26 and 27: Pharmacological inhibition of nitri
Page 28 and 29: 1.4 The nitric oxide pathway in ath
Page 30 and 31: of NADPH, FAD and FMN, whereas the
Page 32 and 33: isoforms to the regulatory and targ
Page 34 and 35: perinuclear/golgi region within the
Page 36 and 37: nNOS interacts with several protein
Page 38 and 39: iNOS expression is regulated transc
Page 40 and 41: transport pathway and is an essenti
Page 42 and 43: Interestingly, BH4 supplementation
Page 44 and 45: the survival rate, as apoE/nNOS dko
Page 46 and 47: The seemingly opposing effects of i
Page 48 and 49: The purpose of the study presented
Page 50 and 51: 2.0 Materials and Methods 2.1 Mater
Page 52 and 53: Reagents Source For Immunohistochem
Page 54 and 55: Others Reagents Source Pegulated Su
Page 56 and 57:
2.2 Methods 2.2.1 Detection of free
Page 58 and 59:
2.2.1.2 Principle of ESR ESR spectr
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spectra 190 . Addition of exogenous
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ings were prepared as mentioned abo
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X-band EMX spectroscope (Bruker Bio
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minutes. At last sections were wash
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3.0 Results 3.1 eNOS is a significa
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3.2 eNOS deletion decreases vascula
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3.3 nNOS contributes little to vasc
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3.5 iNOS contributes significantly
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Figure 13. Determination of iNOS de
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3.8 iNOS deletion influences NADPH
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4.0 Discussion 4.1 eNOS is a major
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in our apoE/eNOS dko model, these a
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under conditions of substrate or co
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vessels with the iNOS specific inhi
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Summary and Hypothesis The principl
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Zusammenfassung und Hypothese Stick
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Bibliography 1. Gimbrone MA, Jr. Va
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xanthine oxidase contributes to vas
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expression of adhesion molecules an
Page 98 and 99:
transforming growth factor-beta 1.
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generation from neuronal nitric oxi
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148. Lee PC, Wang ZL, Qian S, Watki
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174. Mayr U, Zou Y, Zhang Z, Dietri
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implications in intracellular fluor
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Definitions Thesaurus • Allograft
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• Claudication refers to leg pain
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cases per year in the US. It is a n
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Curriculum Curriculum vitae vitae N
Page 116 and 117:
presentation at the 37 th Annual co
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First 11 pages of thesis. - OPUS - Universität Würzburg

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