First 11 pages of thesis. - OPUS - Universität Würzburg
First 11 pages of thesis. - OPUS - Universität Würzburg
First 11 pages of thesis. - OPUS - Universität Würzburg
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3.8 iNOS deletion influences NADPH oxidase mediated<br />
superoxide production<br />
Since iNOS expression may regulate NADPH oxidase activity and<br />
expression we determined the contribution <strong>of</strong> NADPH oxidase to superoxide<br />
formation in apoE ko vessels. Our results show that apocynin, a NADPH<br />
oxidase inhibitor significantly reduced superoxide levels compared to basal<br />
superoxide production <strong>of</strong> apoE ko vessels (13±0.6 AU/µg protein, (n=13) vs.<br />
19±1.0 AU/µg protein, (n=12), p