First 11 pages of thesis. - OPUS - Universität Würzburg

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Curriculum Curriculum vitae vitae Name : P. Padmapriya Sex : Female Date of Birth : 03-03-1980 Nationality : Indian Present address : 114, Schwestern Wohnheim-2 Straubmülweg No. Nr Würzburg, D97078 Germany Tel : 0049 17661118717 Fax : 0049 931 201 36664 Email : pppris@yahoo.com Permanent address : 61/23, Sowthamalar layout Educational Qualification Ramaswamy nagar Udumalpet-642126 Coimbatore District, Tamilnadu INDIA 1. Bachelor of Science : B.Sc Biotechnology (2000) Bharathiyar University, Coimbatore Tamilnadu, India Division: First class with distinction 2. Master of Science : M.Sc Biotechnology (2002) Bharathidasan University, Tiruchirapalli Tamilnadu, India Division: First class - 102 -
Awards Awards • Proficiency Prize holder in graduation. • Secured Gold Medal and University 3 rd rank in graduation. • Won prizes in inter-department quiz competitions in college. • Won prize in state level essay writing competition. Oral Oral and and poster poster presentations presentations presentations • Padmapriya Ponnuswamy, E. Ostermeier, P. Kuhlencordt . Inducible nitric oxide synthase (iNOS) modulates oxidative stress in vessels of atherosclerotic mice; Oral presentation at the 72 nd Annual conference of the German society for cardiology (DGK), 20-22 nd April, 2006. • Padmapriya Ponnuswamy, E. Ostermeier, A.Schröttle, G. Ertl and P. Kuhlencordt. Alternative chemistry of inducible nitric oxide synthase (iNOS) in atherosclerosis; Oral presentation at the 36 th Annual conference of the German society for angiology (DGA) and the 14 th Conference of the German, Austrian and Swiss societies for angiology, 9-12 th September, 2007. • Padmapriya Ponnuswamy, Angelika Schröttle, Eva Ostermeier, Sabine Grüner, David Varga-Szabo, Paul Huang, Georg Ertl, Bernhard Nieswandt, Peter Kuhlencordt. Endothelial nitric oxide production inhibits leukocyte endothelial cell- but not platelet endothelial cell interactions; Poster presentation at the Scientific sessions meeting of American Heart Association, 4-7 th November, 2007. • Padmapriya Ponnuswamy, Angelika Schröttle, Sabine Grüner, Andreas Schäfer, Paul Huang , Johann Bauersachs, Bernhard Nieswandt, Georg Ertl and Peter Kuhlencordt. Role of nNOS in endothelial relaxation and leukocyte/endothelial cell (L/E-) interactions in atherosclerosis; Oral - 103 -
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Insight into oxidative stress media
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Eidesstattliche Erklärungen Hiermi
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Acknowledgements First and foremost
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“Research is to see what everybod
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Chapter 2 37 2.0 Materials and Meth
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Summary and Hypothesis 76 Zusammenf
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1.0 Introduction Atherosclerosis, t
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which contribute to the lipid rich
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1.2 Risk Factors Atherosclerosis ha
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1.2.2 Environmental factors 1. High
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1.3 Oxidative Stress Oxidative stre
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peroxynitrite 38 which by itself ca
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Pharmacological inhibition of nitri
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1.4 The nitric oxide pathway in ath
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of NADPH, FAD and FMN, whereas the
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isoforms to the regulatory and targ
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perinuclear/golgi region within the
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nNOS interacts with several protein
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iNOS expression is regulated transc
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transport pathway and is an essenti
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Interestingly, BH4 supplementation
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the survival rate, as apoE/nNOS dko
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The seemingly opposing effects of i
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The purpose of the study presented
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2.0 Materials and Methods 2.1 Mater
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Reagents Source For Immunohistochem
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Others Reagents Source Pegulated Su
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2.2 Methods 2.2.1 Detection of free
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2.2.1.2 Principle of ESR ESR spectr
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spectra 190 . Addition of exogenous
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ings were prepared as mentioned abo
Page 64 and 65: X-band EMX spectroscope (Bruker Bio
Page 66 and 67: minutes. At last sections were wash
Page 68 and 69: 3.0 Results 3.1 eNOS is a significa
Page 70 and 71: 3.2 eNOS deletion decreases vascula
Page 72 and 73: 3.3 nNOS contributes little to vasc
Page 74 and 75: 3.5 iNOS contributes significantly
Page 76 and 77: Figure 13. Determination of iNOS de
Page 78 and 79: 3.8 iNOS deletion influences NADPH
Page 80 and 81: 4.0 Discussion 4.1 eNOS is a major
Page 82 and 83: in our apoE/eNOS dko model, these a
Page 84 and 85: under conditions of substrate or co
Page 86 and 87: vessels with the iNOS specific inhi
Page 88 and 89: Summary and Hypothesis The principl
Page 90 and 91: Zusammenfassung und Hypothese Stick
Page 92 and 93: Bibliography 1. Gimbrone MA, Jr. Va
Page 94 and 95: xanthine oxidase contributes to vas
Page 96 and 97: expression of adhesion molecules an
Page 98 and 99: transforming growth factor-beta 1.
Page 100 and 101: generation from neuronal nitric oxi
Page 102 and 103: 148. Lee PC, Wang ZL, Qian S, Watki
Page 104 and 105: 174. Mayr U, Zou Y, Zhang Z, Dietri
Page 106 and 107: implications in intracellular fluor
Page 108 and 109: Definitions Thesaurus • Allograft
Page 110 and 111: • Claudication refers to leg pain
Page 112 and 113: cases per year in the US. It is a n
Page 116 and 117: presentation at the 37 th Annual co
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First 11 pages of thesis. - OPUS - Universität Würzburg

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