Reference Manual - IARC Screening Group

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Cervical Cancer PreventionGuidelines for Low-Resource SettingsWith funding from the Bill and Melinda Gates Foundationthrough the Alliance for Cervical Cancer Prevention
TABLE OF CONTENTSPREFACE AND ACKNOWLEDGMENTS.............................................................................. xiABBREVIATIONS AND ACRONYMS................................................................................... xiiONEINTRODUCTIONMagnitude of the Problem ...................................................................................... 1-1Background............................................................................................................. 1-1HIV/AIDS, HPV Infection, and Cervical Cancer................................................... 1-3Risk Factors for HPV and Cervical Cancer ............................................................ 1-4Preventing Cervical Cancer .................................................................................... 1-5Treatment .............................................................................................................. 1-10Factors Affecting Choice of Treatment ................................................................ 1-11Managing Precancerous Cervical Disease............................................................ 1-13Treating Women with Unconfirmed Disease ....................................................... 1-14Links to Other Reproductive Health Services ...................................................... 1-14References............................................................................................................. 1-16TWOHUMAN PAPILLOMAVIRUS AND CERVICAL CANCERBackground............................................................................................................. 2-1The Virus ................................................................................................................ 2-2How HPV Induces Cancer...................................................................................... 2-3Risk Factors for Cervical Cancer............................................................................ 2-4Preventing Cervical Cancer .................................................................................... 2-5Primary Prevention ................................................................................................. 2-6Secondary Prevention ............................................................................................. 2-8References............................................................................................................... 2-8THREEPATHOPHYSIOLOGY OF CERVICAL CANCERBackground............................................................................................................. 3-1Key Considerations for Low-Resource Settings..................................................... 3-2Anatomy and Physiology of the Normal Cervix..................................................... 3-2Appearance of the Cervix in Normal and Abnormal States ................................... 3-4References............................................................................................................. 3-11Cervical Cancer Prevention Guidelines for Low-Resource Settingsiii
Page 1: Cervical Cancer PreventionGuideline
Page 8: How to High-Level Disinfect Surgica
Page 11 and 12: Table C-2Figure C-1Preparing a Dilu
Page 13 and 14: PREFACE AND ACKNOWLEDGMENTSThis ref
Page 15 and 16: ONEINTRODUCTIONMAGNITUDE OF THE PRO
Page 17 and 18: IntroductionFigure 1-3. Incidence o
Page 19 and 20: Introductionprevalence areas, a sta
Page 21 and 22: Table 1-2. Reduction in Cumulative
Page 23 and 24: Introductiontheir performance was t
Page 25 and 26: Introductionlesions, or a false pos
Page 27 and 28: IntroductionCompared to other metho
Page 29 and 30: Introductionsignificantly to women
Page 31 and 32: IntroductionBelinson JL et al. 2001
Page 33 and 34: IntroductionMitchell MF et al. 1998
Page 35 and 36: IntroductionYlitalo N et al. 1999.
Page 37 and 38: TWOHUMAN PAPILLOMAVIRUS AND CERVICA
Page 39 and 40: Human Papillomavirus and Cervical C
Page 47 and 48: THREEPATHOPHYSIOLOGY OF CERVICAL CA
Page 49 and 50: With the onset of puberty, whichis
Page 51 and 52: Pathophysiology of Cervical Cancerp
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Pathophysiology of Cervical CancerP
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Pathophysiology of Cervical CancerI
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Pathophysiology of Cervical CancerR
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FOURTALKING WITH WOMEN ABOUTCERVICA
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Talking with Women About Cervical C
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FIVEPREVENTING INFECTIONS INHEALTHC
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Preventing Infections in Healthcare
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SIXCLIENT ASSESSMENT AND VIA TESTIN
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Client Assessment and VIA TestingFi
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Client Assessment and VIA TestingIN
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Client Assessment and VIA Testingst
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Client Assessment and VIA Testingsp
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Client Assessment and VIA Testingth
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SEVENTREATMENT AND FOLLOWUPBACKGROU
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Treatment and Followupregardless of
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Treatment and FollowupFigure 7-1. L
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Treatment and FollowupTable 7-6. Co
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Treatment and FollowupFigure 7-2 is
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Treatment and Followup• Regulator
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Treatment and FollowupCRYOTHERAPY P
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Treatment and FollowupStep 6 Point
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Treatment and FollowupNote: When CO
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Treatment and FollowupStep 5Advise
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Treatment and FollowupBerget A, B A
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APPENDIX ATESTS FOR CERVICAL CANCER
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Tests for Cervical Cancer Screening
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APPENDIX BSCREENING TEST QUALITIES
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Screening Test Qualities and Their
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APPENDIX CINFECTION PREVENTION PROC
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Infection Prevention Processesfor m
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Infection Prevention Processeswith
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Infection Prevention ProcessesFigur
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Table C-4. Preparing and Using Chem
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Infection Prevention ProcessesStora
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Infection Prevention Processes• h
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APPENDIX DTECHNICAL OVERVIEW OF THE
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Technical Overview of the Cryothera
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Figure D-5. Removing Protector Tube
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Technical Overview of the Cryothera
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Figure D-11. Gas Cylinder Secured t
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APPENDIX ETROUBLESHOOTING WITH THEC
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Table E-1. Following-Up on Commonly
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APPENDIX FPROCESSING SURGICAL GLOVE
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Processing Surgical GlovesTable F-1
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Processing Surgical GlovesSTEP 10:
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APPENDIX GPERFORMING BREAST AND PEL
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Performing Breast and Pelvic Examin
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Figure G-2. Breast Puckering or Dim
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Figure G-5. Checking for Nipple Dis
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Figure G-18. Speculum in Place with
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APPENDIX HPERCEIVED BARRIERS TO PRO
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AVAILABILITY OF BASIC SUPPLIES AND
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GLOSSARYAcetic AcidAcetowhite Chang
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PatulousSquamocolumnarJunction (SCJ
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ADDITIONAL READINGAlliance for Cerv
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Reference Manual - IARC Screening Group

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