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Reference Manual - IARC Screening Group

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Treatment and FollowupFigure 7-1. LEEPSource: Bishop, Sherris and Tsu 1995; Wright, Richart and Ferenczy 1992.Table 7-5. LEEP Success RatesSTUDYMitchell et al.(1998)Prendiville,Cullimore andNormal (1989)Gunasekera,Phipps and Lewis(1990)Bigrigg et al.(1990)Luesley et al.(1993)Wright, Richartand Ferenczy(1992)Keijser et al.(1992)NUMBEROFWOMENCIN IIICURERATE (%)OVERALLCURERATE (%)FOLLOWUPIN YEARS130 81 a N/C b 1.5 (mean)102 99 97 1.5 (mean)98 95 95 0.5659 96 96 0.3557 96 97 0.5141 94 95 0.5395 81 4.8 (mean)a Randomized trial differences in cure rates for cryotherapy and LEEP not statisticallysignificant.b Not calculated.Source: Bigrigg et al. 1990; Gunasekera, Phipps and Lewis 1990; Keijser et al. 1992;Luesley et al. 1993; Mitchell et al. 1998; Prendiville, Cullimore and Normal 1989;Wright, Richart and Ferenczy 1992.A disadvantage of LEEP is that local anesthesia (paracervical block) isrequired to minimize discomfort. Also, the equipment, consisting of anelectrosurgical generator, smoke evacuating system and disposable wireloops (reusable loops are available but have a limited number of reuses),is expensive. The procedure has few side effects; the main complicationis a 3% perioperative bleeding rate (Mitchell et al. 1998).Cervical Cancer Prevention Guidelines for Low-Resource Settings 7-5

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