Analgesia Table 5.6.4 Urological SurgeryAgentTechniqueDirectevidenceLA Epidural 1)LA + opioid Epidural 1)LA Caudal epidural 1)LA Paravertebral block 2)LA a Wound <strong>in</strong>filtration 3Opioid a Intravenous 3 1+NSAID a 3 1+Paracetamol a 3 1+a As part of a multimodal technique.5.7 Laparoscopic surgeryIndirectevidenceThere has been a dramatic <strong>in</strong>crease <strong>in</strong> the amount ofpediatric laparoscopic surgery <strong>in</strong> the last decade. Thisis performed ma<strong>in</strong>ly through the body cavities (chest<strong>and</strong> abdomen) or potential spaces. Ingu<strong>in</strong>al herniarepair, appendicectomy, fundoplication, urological <strong>and</strong>adrenal surgery are examples. For general managementof postoperative pa<strong>in</strong>, see section 5.1.<strong>Good</strong> practice po<strong>in</strong>tsInfiltration of port sites with LA as part of a multimodalanalgesic strategy may reduce postoperativepa<strong>in</strong> follow<strong>in</strong>g laparoscopy.Although overall postoperative analgesic requirementsappear to be reduced follow<strong>in</strong>g laparoscopy, pa<strong>in</strong> maybe equivalent to the equivalent open procedure <strong>in</strong>some circumstances, particularly dur<strong>in</strong>g the first 24 h.EvidenceAdvantages of laparoscopic surgery may <strong>in</strong>clude fasterrecovery <strong>and</strong> overall reduction <strong>in</strong> pa<strong>in</strong> <strong>and</strong> use of opioidanalgesia <strong>in</strong> comparison with the open surgicalcounterpart (246,267–272). Although the overall durationof postoperative pa<strong>in</strong> appears to be reduced, analgesicrequirements may be at least as great on the firstpostoperative day as the equivalent open procedure(261,267,273–275). The use of robotic laparoscopictechniques may also decrease postoperative opioidrequirements after ureteric reimplantation surgery(276). The anatomical approach to laparoscopic surgeryhas not been shown to effect analgesic requirements(277,278).Multimodal analgesia <strong>in</strong>clud<strong>in</strong>g LA <strong>in</strong>filtration, opioid,NSAID, <strong>and</strong> paracetamol is suitable, <strong>and</strong> the useof carefully designed protocols may improve efficacy(279). Dem<strong>and</strong>-led opioid regimens such as PCA orNCA are feasible <strong>and</strong> effective for some procedures<strong>and</strong> require further evaluation (246,262).LA <strong>in</strong>filtration of port sites when comb<strong>in</strong>ed withNSAID provided equivalent analgesia to caudal blockfor m<strong>in</strong>or diagnostic <strong>and</strong> therapeutic laparoscopic procedures<strong>and</strong> to TAP block follow<strong>in</strong>g appendicectomy(280,281). Use of aerosolised bupivaca<strong>in</strong>e after port<strong>in</strong>sertion, as part of a multimodal analgesic regimen,demonstrated some opioid spar<strong>in</strong>g effect (282).Perioperative regional LA techniques have also beenshown to be effective <strong>and</strong> aga<strong>in</strong> require further evaluation(271,279). Little good evidence exists with regardto the optimum analgesic regimen.Analgesia Table 5.7 Laparoscopic surgeryAgentTechniqueLA* Infiltration 1)LA* Aerosolised 3LA Caudal 1)Opioid Parenteral/oral 3NSAID a 1)Paracetamol a 3a As part of a multimodal technique.DirectevidenceIndirectevidence5.8 Orthopedics, sp<strong>in</strong>al <strong>and</strong> plastic surgery5.8.1 Lower limb surgeryThe surgery covered <strong>in</strong> this section ranges from relativelym<strong>in</strong>or s<strong>in</strong>gle site orthopedic surgery to moremajor procedures such as multiple level osteotomies.The population of patients requir<strong>in</strong>g femoral <strong>and</strong>pelvic osteotomies <strong>in</strong>cludes those suffer<strong>in</strong>g from cerebralpalsy; pa<strong>in</strong> <strong>in</strong> this population can also precipitatepa<strong>in</strong>ful muscle spasm requir<strong>in</strong>g specific managementwith benzodiazep<strong>in</strong>es.Multimodal analgesia is suitable: there is particularlyextensive experience of the use of local anesthetic techniquesfor this type of surgery. Concerns have beenexpressed that NSAIDs may <strong>in</strong>hibit new bone growthfollow<strong>in</strong>g orthopedic surgery; this is addressed below.<strong>Good</strong> practice po<strong>in</strong>tThere is no evidence from studies <strong>in</strong> children thatNSAIDs have a deleterious effect on bone fusion. Theanalgesic benefit of short-term NSAID use has beendemonstrated <strong>and</strong> may frequently outweigh any hypotheticalrisk.48 ª 2012 Blackwell Publish<strong>in</strong>g Ltd, Pediatric Anesthesia, 22 (Suppl. 1), 1–79
RecommendationsPeripheral nerve blocks provide superior analgesia <strong>and</strong>are associated with fewer adverse effects compared with<strong>in</strong>travenous opioids: Grade B (283,284).Epidural opioids are effective, reduce the dose requirementsof local anesthetic, <strong>and</strong> rescue IV opioids but<strong>in</strong>crease the <strong>in</strong>cidence of side effects: Grade B(259,285,286).Cont<strong>in</strong>uous peripheral nerve blocks are feasible, effective,<strong>and</strong> safe <strong>and</strong> are associated with lower pa<strong>in</strong> scores:Grade B (287–295).Epidural techniques are associated with lower pa<strong>in</strong>scores than <strong>in</strong>travenous opioid analgesia: Grade C(237,257,296,297).Systemic paracetamol <strong>and</strong> NSAID reduce <strong>in</strong>travenousopioid requirements: Grade C (298,299).EvidenceStudies have shown epidural analgesia us<strong>in</strong>g opioids,local anesthesia or a mixture of the two are effectivebut differences <strong>in</strong> efficacy <strong>and</strong> side effects between regimensare observed. Epidural opioids improve analgesiabut side effects are more frequent. The side effectprofile may be related to the <strong>in</strong>dividual properties ofspecific opioids: morph<strong>in</strong>e, fentanyl, <strong>and</strong> hydromorphonewere of comparable analgesic efficacy <strong>in</strong> onestudy; respiratory depression, somnolence, <strong>and</strong> retentionof ur<strong>in</strong>e were higher <strong>in</strong> the morph<strong>in</strong>e group;PONV <strong>and</strong> ur<strong>in</strong>ary retention had the lowest <strong>in</strong>cidencewith hydromorphone (285). S<strong>in</strong>gle-dose epidural morph<strong>in</strong>ewas equianalgesic with <strong>in</strong>creas<strong>in</strong>g dose (11.2, 15,<strong>and</strong> 20 lgÆkg )1 ), but the <strong>in</strong>cidence of PONV <strong>in</strong>creasedwith dose (300). In a study compar<strong>in</strong>g bupivaca<strong>in</strong>e+ fentanyl with bupivaca<strong>in</strong>e (both with adrenal<strong>in</strong>e),the fentanyl group had superior analgesia <strong>and</strong>did not require rescue opioid but had a higher <strong>in</strong>cidenceof PONV, whereas the bupivaca<strong>in</strong>e grouprequired more bupivaca<strong>in</strong>e <strong>and</strong> 10/26 (38%) requiredrescue opiates <strong>and</strong> antiemetic therapy, itch<strong>in</strong>g onlyoccurred <strong>in</strong> the fentanyl group (286).Epidural vs peripheral nerve blockA comparison of cont<strong>in</strong>uous epidural block with cont<strong>in</strong>uouspopliteal nerve block for major foot surgery showedno difference <strong>in</strong> pa<strong>in</strong> or rescue analgesia, but adverseeffects <strong>and</strong> patient satisfaction were improved withperipheral nerve block (290). In congenital club foot surgery,a comparison of s<strong>in</strong>gle-shot caudal anesthesia withs<strong>in</strong>gle-shot peripheral nerve blocks (comb<strong>in</strong>ed sciatic femoral,comb<strong>in</strong>ed sciatic saphenous, <strong>and</strong> saphenous comb<strong>in</strong>edwith local <strong>in</strong>filtration) showed no difference <strong>in</strong> theduration of analgesia <strong>and</strong> no difference <strong>in</strong> morph<strong>in</strong>e consumptionwith<strong>in</strong> the first 24 h, there was no difference <strong>in</strong>the <strong>in</strong>cidence of nausea <strong>and</strong> vomit<strong>in</strong>g between any of thegroups (301). S<strong>in</strong>gle-shot Psoas Compartment Blockshowed moderate reduction <strong>in</strong> postoperative opioidrequirements compared to caudal epidural follow<strong>in</strong>gopen hip reduction or osteotomy (302).Epidural compared with Intravenous techniquesIn a comparison between patient-controlled epiduralanalgesia (PCEA) with lidoca<strong>in</strong>e, <strong>and</strong> nurse-controlledIV fentanyl, pa<strong>in</strong> scores (unvalidated method), <strong>and</strong>PONV were lower <strong>in</strong> the epidural group (297). A s<strong>in</strong>gledose of epidural morph<strong>in</strong>e 30 lgÆkg )1 reduced postoperativePCA morph<strong>in</strong>e use, <strong>and</strong> VAS scores were also lower<strong>in</strong> the epidural morph<strong>in</strong>e group, <strong>and</strong> there was no difference<strong>in</strong> the <strong>in</strong>cidence of severe pruritus or PONV (237).Peripheral nerve block vs <strong>in</strong>travenous techniquesComparisons between peripheral nerve blocks <strong>and</strong><strong>in</strong>travenous morph<strong>in</strong>e <strong>in</strong> pelvic osteotomy (283) <strong>and</strong>patella realignment surgery (284) demonstrate reducedpa<strong>in</strong> scores, reduced morph<strong>in</strong>e consumption <strong>and</strong> areduction <strong>in</strong> the <strong>in</strong>cidence of sedation with the use ofperipheral nerve blocks.A number of successful series of peripheral nerveblocks have been described, <strong>in</strong>clud<strong>in</strong>g popliteal nerveblock (288,290,292–294,303), fascia iliaca compartmentblock (288,303,304), sciatic nerve block(289,291,295,305),psoas compartment block (287,293), <strong>and</strong> femoral nerveblock (284,304).Cont<strong>in</strong>uous LA <strong>in</strong>fusion vs PCRA/PCEAPCRA (Ropivaca<strong>in</strong>e 0.2%) showed similar efficacy toa cont<strong>in</strong>uous regional technique, with a lower totaldose of LA for popliteal <strong>and</strong> fascia iliaca blocks (303).In a comparison of PCEA vs CEA, aga<strong>in</strong> efficacy wassimilar <strong>and</strong> a lower dose of LA used (306).Systemic analgesia with NSAID <strong>and</strong> paracetamolcan be comb<strong>in</strong>ed with <strong>in</strong>travenous opioid or regionalanalgesia. In one study, a comb<strong>in</strong>ation of paracetamol<strong>and</strong> ketoprofen significantly decreased pa<strong>in</strong> scores <strong>and</strong>IV morph<strong>in</strong>e requirements compared to either drugalone (299). In a case series of patients undergo<strong>in</strong>gclub foot surgery <strong>and</strong> long bone osteotomy, ketorolacreduced IV morph<strong>in</strong>e usage <strong>and</strong> associated GI effectsª 2012 Blackwell Publish<strong>in</strong>g Ltd, Pediatric Anesthesia, 22 (Suppl. 1), 1–79 49
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- Page 26 and 27: Good practice pointLubricant contai
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- Page 30 and 31: 12 Bellieni C, Bagnoli F, Perrone S
- Page 32 and 33: venipuncture pain in a pediatric em
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- Page 44 and 45: was more effective with less motor
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- Page 70 and 71: enhance systemic absorption. Lidoca
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