A Practical Approach, Second Edition=Ronald D. Ho.pdf

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Organ/StructureCodeNumberObservation10110 <strong>Ho</strong>lorachischisis Fissure of the entire spinal column [Craniorachischisis]10111 Hypospadias Urethra opening on the underside of thepenis or on the perineumNot readily apparent infetuses or soon after birth10112 Increased anogenitalIncreased anogenital distance (AGD)distance10113 Kyphosis Humpback,HunchbackIncreased convexity in the curvature ofthe thoracic spinal column as viewedfrom the side10114 Lordosis <strong>Ho</strong>llowback,Swayback,SaddlebackAnterior concavity in the curvature of thelumbar and cervical spinal column asviewed from the side10115 Omphalocele Exomphalos Protrusion of intra-abdominal viscerainto the umbilical cord with visceracontained in a thin translucent sac ofperitoneum and amnion10116 Scoliosis Lateral curvature of the spinal column10117 Short trunk10118 Small anus10119 Small genital tubercle Hypoplastic, Reduced,Rudimentary10120 Spina bifida Meningocele,Meningomyelocele,Myelocele,Myelomeningocele,RachischisisA family of defects in the closure of thespinal columnThe condition may presentwith ruptured sacMay be covered with skin(spina bifida oculta); mayinvolve protrusion of spinalcord and/or meninges10121 Thoracogastroschisis Thoracoceloschisis Failure of closure leaving the thoracicand abdominal cavities, or major partsthereof, exposed ventrally10122 Thoracoschisis Fissure of thoracic wall Lung(s) may be herniated10123 Thoracostenosis Narrowness of the thoracic region10124 Umbilical hernia Protrusion of a skin-covered segment ofthe gastrointestinal tract and/or greateromentum through a defect in theabdominal wall at the umbilicus, theherniated mass being circumscribedand covered with skin; or protrusion ofskin-covered viscera through theumbilical ring with prominence of thenavel1For terms in brackets, see Appendix 1-B below.Synonym orRelated TermNon-preferredTerm Definition NoteTERMINOLOGY OF ANATOMICAL DEFECTS 927© 2006 by Taylor & Francis Group, LLC
Terminology of developmental abnormalities in common laboratory mammals (version 1): Visceral abnormalities 1Region/Organ/StructureCodeNumberObservationSynonym orRelated TermNon-preferredTerm Definition NoteGeneral 10125 Aneurysm Localized sac formed by distention of anartery or vein that is filled with blood10126 Fluid-filled abdomen Ascites, Hemorrhage Effusion and accumulation of watery fluid(ascites) or blood (hemorrhage)10127 Situs inversus Mirror-image transposition of theabdominal and/or thoracic visceraBrain 10128 Dilated cerebralventricleBulbousSlight to moderate dilatation of cerebralventricles, with no evidence of decreasein cortical thickness10129 Hemorrhagiccerebellum10130 Hemorrhagic cerebrum10131 Hydrocephaly Excessive cerebrospinal fluid within theskull10132 Misshapen cerebellum Abnormally shaped,Irregularly shaped10133 Misshapen cerebrum Abnormally shaped,Irregularly shaped10134 Small cerebellum Hypoplastic, Reduced,Rudimentary10135 Small cerebrum Hypoplastic, Reduced,RudimentaryEar 10136 Misshapen inner ear Abnormally shaped,Irregularly shapedEye 10137 Anophthalmia Agenesis, Aplastic Absence of eye(s)10138 Aphakia Agenesis, Aplastic Absence of lens10139 Cataract Opacity of the crystalline lens10140 Hemorrhagic eye10141 Macrophthalmia MegalophthalmiaLarge eye, eyeball(-mus,-mos)10142 Malpositioned eye Displaced, Ectopic10143 Microphthalmia Hypoplastic, Reduced,Small eyeRudimentary10144 Misshapen lens Abnormally shaped,Irregularly shapedMay be further defined bylocationIncludes absence ofinterhemispheric fissure928 DEVELOPMENTAL REPRODUCTIVE TOXICOLOGY: A PRACTICAL APPROACH, SECOND EDITION© 2006 by Taylor & Francis Group, LLC
Page 2 and 3: Second EditionDEVELOPMENTALandREPRO
Page 4 and 5: Published in 2006 byCRC PressTaylor
Page 6 and 7: Chapter 12Chapter 13Chapter 14Chapt
Page 8 and 9: The EditorRonald D. Hood, Ph.D., is
Page 10 and 11: Alan M. HobermanArgus ResearchHorsh
Page 12 and 13: APPENDIX ATerminology of Anatomical
Page 14 and 15: TERMINOLOGY OF ANATOMICAL DEFECTS 9
Page 24 and 25: Organ/StructureCodeNumberObservatio
Page 30 and 31: Organ/Structure10145 Ocular colobom
Page 34 and 35: Organ/StructurePulmonaryarteryPulmo
Page 42 and 43: Terminology of developmental abnorm
Page 54 and 55: Organ/StructureCervicalcentrumCodeN
Page 56 and 57: Organ/Structure10689 Misshapen thor
Page 58 and 59: Organ/StructureSacralcentrumSacralv
Page 68 and 69: 968 DEVELOPMENTAL REPRODUCTIVE TOXI
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978 DEVELOPMENTAL REPRODUCTIVE TOXI
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1000 DEVELOPMENTAL REPRODUCTIVE TOX
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Table 1Human Non-human Primate Rat
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Table 1 (continued)Sertoli CellsHum
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Table 2 (continued) Landmarks in th
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Table 2 (continued) Landmarks in th
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POSTNATAL DEVELOPMENTAL MILESTONES
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PART IPrinciples and Mechanisms© 2
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4 DEVELOPMENTAL REPRODUCTIVE TOXICO
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10 DEVELOPMENTAL REPRODUCTIVE TOXIC
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Table 2.6Receptor(Official Name a )
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Clearly, more research needs to be
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CHAPTER 6Comparative Features of Ve
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COMPARATIVE FEATURES OF VERTEBRATE
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Table 6.2Comparative reproductive a
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Maturation andRelease ofGametesSper
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Amniotic cavity 9.5 1.5 1-4 1-4,6,9
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Posteriorcardinal veinsestablishedT
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PosteriorcardinaldegenerationRight
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StomachappearsThirdpharyngealpouch;
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Table 6.6DescriptionComparative ges
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ParathyroidParathyroids 12.5 6.2 41
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Table 6.8DescriptionComparative ges
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Formation ofchoroid plexusof latera
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Optic nervefibers presentDifferenti
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Table 6.10DescriptionMuscular Syste
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Distalphalanges offingersseparatedF
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Table 6.11DescriptionIntermediateme
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Table 6.12DescriptionComparative ge
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CHAPTER 7Developmental Toxicity Tes
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DEVELOPMENTAL TOXICITY TESTING —
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Female 0.00-0.69 0.004-0.39 0.00-0.
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Figure 8.11775Pott DescribesScrotal
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The underlying physiology of juveni
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Table 8.5Total body composition by
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Table 8.6Serum chemistry values for
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Table 8.7Parameter bHematology valu
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CHAPTER 9Significance, Reliability,
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DEVELOPMENTAL AND REPRODUCTIVE TOXI
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Prior to the early 1980s, numerous
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Figure 9.51906Food andDrugs Act2000
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Table 9.18Selected comparison point
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Table 9.33Selected comparison point
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Table 9.48What do regulatorswant to
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CHAPTER 10Testing for Reproductive
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TESTING FOR REPRODUCTIVE TOXICITY 4
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We would like to acknowledge the ef
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CHAPTER 12Role of Xenobiotic Metabo
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ROLE OF XENOBIOTIC METABOLISM IN DE
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y ESR spectrometry. 122 Further ESR
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CHAPTER 13Use of Toxicokinetics in
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USE OF TOXICOKINETICS IN DEVELOPMEN
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CHAPTER 17Statistical Analysis for
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STATISTICAL ANALYSIS FOR DEVELOPMEN
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CHAPTER 19Perspectives on the Devel
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PERSPECTIVES ON THE DEVELOPMENTAL A
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Guideline OECD 415 (One Generation)
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The Office of Prevention, Pesticide
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CHAPTER 20Human Studies — Epidemi
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HUMAN STUDIES 801I. INTRODUCTIONEpi
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HUMAN STUDIES 803is actively trying
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HUMAN STUDIES 805100908070Induced a
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HUMAN STUDIES 8071009590>37 w33-36
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HUMAN STUDIES 80940003500Mean birth
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HUMAN STUDIES 811from monstrous, us
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HUMAN STUDIES 829B. The Formation o
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HUMAN STUDIES 837with spina bifida
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HUMAN STUDIES 83926. Haglund, B. an
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CHAPTER 21Developmental and Reprodu
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There are six factors that may affe
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