A Practical Approach, Second Edition=Ronald D. Ho.pdf

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Organ/StructureCodeNumberObservationSynonym orRelated Term10619 Sternoschisis Bifid, Bipartite, CleftsternumSplit sternum involving the cartilageand one or more sternebral centers10620 Unossified sternebraRib 10621 Absent rib Agenesis, Aplastic Generally the normalnumber of rib pairs is 13in rodent and 12 or 13 inrabbit; but must berelated to normal numberfor given species, strain,and time in eachlaboratory.10622 Bent rib Angulated, Bowed Shaped like an angle10623 Branched rib Bifurcated, Forked Split A rib that divides distally into two ribs10624 Branched rib cartilage Bifurcated, Forked A rib cartilage that divides distally intotwo10625 Cervical rib Supernumerary cervical Ossification lateral to a cervical arch Usually seen on lastcervical arch10626 Detached rib Floating rib Rib with no attachment to the vertebralcolumn10627 Discontinuous rib Interrupted ossification Absence of cartilage and Alizarin Reduptake in a central region of a rib10628 Full supernumerary rib Extra full, LongsupernumerarythoracolumbarNon-preferredTerm Definition NoteLumbar ribAn extra rib that is distally joined by acartilaginous portionGenerally the normalnumber of rib pairs is 13in rodent and 12 or 13 inrabbit; but must berelated to normal numberfor given species, strain,and time in eachlaboratory.10629 Fused rib Specify structures that arefused10630 Fused rib cartilage10631 Incomplete ossification Reduced ossificationof rib10632 Intercostal rib A non-articulating rib-like structurelocated between two other ribs10633 Knobby rib Focal enlargement,A rounded protuberance on a ribNodulated10634 Malpositioned rib Displaced, Ectopic10635 Misaligned rib10636 Misshapen rib Abnormally shaped,Asymmetric, IrregularlyshapedTERMINOLOGY OF ANATOMICAL DEFECTS 951© 2006 by Taylor & Francis Group, LLC
Terminology of developmental abnormalities in common laboratory mammals (version 1): Skeletal abnormalities 1 (continued)Region/Organ/StructureVertebra,GeneralCodeNumberObservation10637 Short rib Rudimentary Not used forsupernumerary rib;generally less than halfnormal length10638 Short supernumeraryribExtra rudimentary,Rudimentarysupernumerarythoracolumbar, ShortsupernumerarythoracolumbarLumbar ribAn extra rib that is usually roundeddistally and without cartilaginousextensionsGenerally the normalnumber of rib pairs is 13in rodent and 12 or 13 inrabbit; but must berelated to normal numberfor given species, strain,and time in eachlaboratory10639 Thickened rib Clubbed10640 Unossified rib10641 Wavy rib Undulation(s) along the length of a rib10642 Absent vertebra Agenesis, Aplastic Used when subregion notspecified10643 Supernumerary Additional, ExtraUsed when subregion notvertebraspecifiedCervical arch 10644 Absent cervical arch Agenesis, Aplastic Atlas = #1, Axis = #210645 Fused cervical arch Specify structures that arefused Atlas = #1,Axis = #210646 Incomplete ossification Reduced ossification Atlas = #1, Axis = #2of cervical arch10647 Malpositioned cervical Displaced, Ectopic Atlas = #1, Axis = #2arch10648 Misaligned cervicalarchAtlas = #1, Axis = #210649 Misshapen cervicalarchSynonym orRelated TermAbnormally shaped,Asymmetric, IrregularlyshapedNon-preferredTerm Definition NoteAtlas = #1, Axis = #210650 Small cervical arch Hypoplastic, Reduced,Atlas = #1, Axis = #2Rudimentary10651 Supernumerarycervical archAdditional, Extra Atlas = #1, Axis = #2952 DEVELOPMENTAL REPRODUCTIVE TOXICOLOGY: A PRACTICAL APPROACH, SECOND EDITION© 2006 by Taylor & Francis Group, LLC
Page 2 and 3: Second EditionDEVELOPMENTALandREPRO
Page 4 and 5: Published in 2006 byCRC PressTaylor
Page 6 and 7: Chapter 12Chapter 13Chapter 14Chapt
Page 8 and 9: The EditorRonald D. Hood, Ph.D., is
Page 10 and 11: Alan M. HobermanArgus ResearchHorsh
Page 12 and 13: APPENDIX ATerminology of Anatomical
Page 14 and 15: TERMINOLOGY OF ANATOMICAL DEFECTS 9
Page 24 and 25: Organ/StructureCodeNumberObservatio
Page 30 and 31: Organ/Structure10145 Ocular colobom
Page 34 and 35: Organ/StructurePulmonaryarteryPulmo
Page 42 and 43: Terminology of developmental abnorm
Page 54 and 55: Organ/StructureCervicalcentrumCodeN
Page 56 and 57: Organ/Structure10689 Misshapen thor
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Page 68 and 69: 968 DEVELOPMENTAL REPRODUCTIVE TOXI
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1002 DEVELOPMENTAL REPRODUCTIVE TOX
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Table 1Human Non-human Primate Rat
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Table 1 (continued)Sertoli CellsHum
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Table 2 (continued) Landmarks in th
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Table 2 (continued) Landmarks in th
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POSTNATAL DEVELOPMENTAL MILESTONES
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PART IPrinciples and Mechanisms© 2
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4 DEVELOPMENTAL REPRODUCTIVE TOXICO
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10 DEVELOPMENTAL REPRODUCTIVE TOXIC
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Table 2.6Receptor(Official Name a )
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Clearly, more research needs to be
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100 DEVELOPMENTAL REPRODUCTIVE TOXI
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CHAPTER 6Comparative Features of Ve
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COMPARATIVE FEATURES OF VERTEBRATE
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Table 6.2Comparative reproductive a
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Maturation andRelease ofGametesSper
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Amniotic cavity 9.5 1.5 1-4 1-4,6,9
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Posteriorcardinal veinsestablishedT
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PosteriorcardinaldegenerationRight
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StomachappearsThirdpharyngealpouch;
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Table 6.6DescriptionComparative ges
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ParathyroidParathyroids 12.5 6.2 41
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Table 6.8DescriptionComparative ges
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Formation ofchoroid plexusof latera
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Optic nervefibers presentDifferenti
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Table 6.10DescriptionMuscular Syste
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Distalphalanges offingersseparatedF
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Table 6.11DescriptionIntermediateme
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Table 6.12DescriptionComparative ge
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CHAPTER 7Developmental Toxicity Tes
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DEVELOPMENTAL TOXICITY TESTING —
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Female 0.00-0.69 0.004-0.39 0.00-0.
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Figure 8.11775Pott DescribesScrotal
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The underlying physiology of juveni
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Table 8.5Total body composition by
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Table 8.6Serum chemistry values for
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Table 8.7Parameter bHematology valu
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CHAPTER 9Significance, Reliability,
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DEVELOPMENTAL AND REPRODUCTIVE TOXI
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Prior to the early 1980s, numerous
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Figure 9.51906Food andDrugs Act2000
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Table 9.18Selected comparison point
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Table 9.33Selected comparison point
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Table 9.48What do regulatorswant to
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CHAPTER 10Testing for Reproductive
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TESTING FOR REPRODUCTIVE TOXICITY 4
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We would like to acknowledge the ef
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CHAPTER 12Role of Xenobiotic Metabo
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ROLE OF XENOBIOTIC METABOLISM IN DE
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y ESR spectrometry. 122 Further ESR
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CHAPTER 13Use of Toxicokinetics in
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USE OF TOXICOKINETICS IN DEVELOPMEN
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CHAPTER 17Statistical Analysis for
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STATISTICAL ANALYSIS FOR DEVELOPMEN
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CHAPTER 19Perspectives on the Devel
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PERSPECTIVES ON THE DEVELOPMENTAL A
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Guideline OECD 415 (One Generation)
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The Office of Prevention, Pesticide
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CHAPTER 20Human Studies — Epidemi
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HUMAN STUDIES 801I. INTRODUCTIONEpi
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HUMAN STUDIES 803is actively trying
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HUMAN STUDIES 805100908070Induced a
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HUMAN STUDIES 8071009590>37 w33-36
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HUMAN STUDIES 80940003500Mean birth
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HUMAN STUDIES 811from monstrous, us
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HUMAN STUDIES 829B. The Formation o
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HUMAN STUDIES 837with spina bifida
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CHAPTER 21Developmental and Reprodu
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