A Practical Approach, Second Edition=Ronald D. Ho.pdf

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Organ/StructureCodeNumberObservationSynonym orRelated TermNon-preferredTerm Definition Note10573 Misshapen radius Abnormally shaped,Irregularly shaped10574 Short radius Rudimentary10575 Thickened radius10576 Unossified radiusUlna 10577 Absent ulna Agenesis, Aplastic, Ulnarhemimelia10578 Bent ulna Angulated, Bowed10579 Fused ulna Specify structures that arefused10580 Incomplete ossification Reduced ossificationof ulna10581 Malpositioned ulna Displaced, Ectopic10582 Misshapen ulna Abnormally shaped,Irregularly shaped10583 Short ulna Rudimentary10584 Thickened ulna10585 Unossified ulnaCarpal bone 10586 Absent carpal bone Agenesis, Aplastic10587 Fused carpal bone Specify structures that arefused10588 Incomplete ossificationof carpal bone10589 Malpositioned carpal Displaced, Ectopicbone10590 Misshapen carpal bone Abnormally shaped,Irregularly shaped10591 Small carpal bone Hypoplastic, Reduced,Rudimentary10592 Supernumerary carpal Additional, Extrabone10593 Unossified carpal boneMetacarpal 10594 Absent metacarpal Agenesis, Aplastic10595 Fused metacarpal Specify structures that arefused10596 Incomplete ossification Reduced ossificationof metacarpal10597 MalpositionedDisplaced, Ectopicmetacarpal10598 Misshapen metacarpal Abnormally shaped,Irregularly shapedTERMINOLOGY OF ANATOMICAL DEFECTS 949© 2006 by Taylor & Francis Group, LLC
Terminology of developmental abnormalities in common laboratory mammals (version 1): Skeletal abnormalities 1 (continued)Region/Organ/StructureCodeNumberObservationSynonym orRelated TermNon-preferredTerm Definition Note10599 Small metacarpal Hypoplastic, Reduced,Rudimentary10600 Supernumerary Additional, Extrametacarpal10601 Unossified metacarpalForepawphalanx10602 Absent phalanx Agenesis, Aphalangia,AplasticAbsence of one or more phalanges inone or more digits10603 Fused phalanx Specify structures that arefused10604 Incomplete ossification Reduced ossificationof phalanx10605 Malpositioned phalanx Displaced, Ectopic10606 Misshapen phalanx Abnormally shaped,Irregularly shaped10607 Small phalanx Hypoplastic, Reduced,Rudimentary10608 Supernumerary Additional, Extraphalanx10609 Thickened phalanx10610 Unossified phalanxSternebra 10611 Absent sternebra Agenesis, Aplastic10612 Bipartite ossification of Bifid ossificationsternebra10613 Extra sternebralossification siteAdditional Supernumerary Refers to advancedossification betweensternebral centers10614 Fused sternebra Specify structures that arefused10615 Incomplete ossification Reduced ossificationof sternebra10616 MalpositionedDisplaced, Ectopicsternebra10617 Misaligned sternebra Offset Checkerboard10618 Misshapen sternebra Abnormally shaped,Asymmetric, Irregularlyshaped950 DEVELOPMENTAL REPRODUCTIVE TOXICOLOGY: A PRACTICAL APPROACH, SECOND EDITION© 2006 by Taylor & Francis Group, LLC
Page 2 and 3: Second EditionDEVELOPMENTALandREPRO
Page 4 and 5: Published in 2006 byCRC PressTaylor
Page 6 and 7: Chapter 12Chapter 13Chapter 14Chapt
Page 8 and 9: The EditorRonald D. Hood, Ph.D., is
Page 10 and 11: Alan M. HobermanArgus ResearchHorsh
Page 12 and 13: APPENDIX ATerminology of Anatomical
Page 14 and 15: TERMINOLOGY OF ANATOMICAL DEFECTS 9
Page 24 and 25: Organ/StructureCodeNumberObservatio
Page 30 and 31: Organ/Structure10145 Ocular colobom
Page 34 and 35: Organ/StructurePulmonaryarteryPulmo
Page 42 and 43: Terminology of developmental abnorm
Page 54 and 55: Organ/StructureCervicalcentrumCodeN
Page 56 and 57: Organ/Structure10689 Misshapen thor
Page 58 and 59: Organ/StructureSacralcentrumSacralv
Page 68 and 69: 968 DEVELOPMENTAL REPRODUCTIVE TOXI
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1000 DEVELOPMENTAL REPRODUCTIVE TOX
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Table 1Human Non-human Primate Rat
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Table 1 (continued)Sertoli CellsHum
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Table 2 (continued) Landmarks in th
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Table 2 (continued) Landmarks in th
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POSTNATAL DEVELOPMENTAL MILESTONES
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PART IPrinciples and Mechanisms© 2
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4 DEVELOPMENTAL REPRODUCTIVE TOXICO
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10 DEVELOPMENTAL REPRODUCTIVE TOXIC
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Table 2.6Receptor(Official Name a )
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Clearly, more research needs to be
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100 DEVELOPMENTAL REPRODUCTIVE TOXI
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CHAPTER 6Comparative Features of Ve
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COMPARATIVE FEATURES OF VERTEBRATE
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Table 6.2Comparative reproductive a
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Maturation andRelease ofGametesSper
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Amniotic cavity 9.5 1.5 1-4 1-4,6,9
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Posteriorcardinal veinsestablishedT
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PosteriorcardinaldegenerationRight
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StomachappearsThirdpharyngealpouch;
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Table 6.6DescriptionComparative ges
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ParathyroidParathyroids 12.5 6.2 41
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Table 6.8DescriptionComparative ges
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Formation ofchoroid plexusof latera
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Optic nervefibers presentDifferenti
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Table 6.10DescriptionMuscular Syste
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Distalphalanges offingersseparatedF
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Table 6.11DescriptionIntermediateme
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Table 6.12DescriptionComparative ge
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CHAPTER 7Developmental Toxicity Tes
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DEVELOPMENTAL TOXICITY TESTING —
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Female 0.00-0.69 0.004-0.39 0.00-0.
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Figure 8.11775Pott DescribesScrotal
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The underlying physiology of juveni
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Table 8.5Total body composition by
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Table 8.6Serum chemistry values for
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Table 8.7Parameter bHematology valu
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CHAPTER 9Significance, Reliability,
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DEVELOPMENTAL AND REPRODUCTIVE TOXI
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Prior to the early 1980s, numerous
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Figure 9.51906Food andDrugs Act2000
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Table 9.18Selected comparison point
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Table 9.33Selected comparison point
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Table 9.48What do regulatorswant to
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CHAPTER 10Testing for Reproductive
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TESTING FOR REPRODUCTIVE TOXICITY 4
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We would like to acknowledge the ef
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CHAPTER 12Role of Xenobiotic Metabo
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ROLE OF XENOBIOTIC METABOLISM IN DE
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y ESR spectrometry. 122 Further ESR
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CHAPTER 13Use of Toxicokinetics in
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USE OF TOXICOKINETICS IN DEVELOPMEN
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CHAPTER 17Statistical Analysis for
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STATISTICAL ANALYSIS FOR DEVELOPMEN
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CHAPTER 19Perspectives on the Devel
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PERSPECTIVES ON THE DEVELOPMENTAL A
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Guideline OECD 415 (One Generation)
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The Office of Prevention, Pesticide
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CHAPTER 20Human Studies — Epidemi
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HUMAN STUDIES 801I. INTRODUCTIONEpi
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HUMAN STUDIES 803is actively trying
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HUMAN STUDIES 805100908070Induced a
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HUMAN STUDIES 80940003500Mean birth
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HUMAN STUDIES 829B. The Formation o
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CHAPTER 21Developmental and Reprodu
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There are six factors that may affe
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