A Practical Approach, Second Edition=Ronald D. Ho.pdf

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Organ/StructureCodeNumberObservationSynonym orRelated TermNon-preferredTerm Definition Note10442 Incomplete ossification Reduced ossificationof frontal10443 Misshapen frontal Abnormally shaped,Asymmetric, Irregularlyshaped10444 Small frontal Hypoplastic, Reduced,Rudimentary10445 Unossified frontalHyoid 10446 Absent hyoid Agenesis, Aplastic10447 Bent hyoid Angulated, Bowed10448 Incomplete ossification Reduced ossificationof hyoid10449 Misshapen hyoid Abnormally shaped,Asymmetric, Irregularlyshaped10450 Small hyoid Hypoplastic, Reduced,Rudimentary10451 Unossified hyoidInterparietal 10452 Absent interparietal Agenesis, Aplastic10453 Bipartite ossification of Bifid ossificationinterparietal10454 Fused interparietal Specify structures that arefused10455 Incomplete ossification Reduced ossificationof interparietal10456 Interparietal hole(s)10457 Misshapen interparietal Abnormally shaped,Asymmetric, Irregularlyshaped10458 Small interparietal Hypoplastic, Reduced,Rudimentary10459 Unossified interparietalLacrimal 10460 Absent lacrimal Agenesis, Aplastic10461 Fused lacrimal Specify structures that arefused10462 Incomplete ossification Reduced ossificationof lacrimal10463 Misshapen lacrimal Abnormally shaped,Irregularly shaped10464 Small lacrimal Hypoplastic, Reduced,RudimentaryTERMINOLOGY OF ANATOMICAL DEFECTS 943© 2006 by Taylor & Francis Group, LLC
Terminology of developmental abnormalities in common laboratory mammals (version 1): Skeletal abnormalities 1 (continued)Region/Organ/StructureCodeNumberObservationSynonym orRelated TermNon-preferredTerm Definition Note10465 Unossified lacrimalMandible 10466 Absent mandible Agenesis, Aplastic10467 Fused mandible Specify structures that arefused10468 Incomplete ossification Reduced ossificationof mandible10469 Misshapen mandible Abnormally shaped,Asymmetric, Irregularlyshaped10470 Small mandible Hypoplastic, Reduced,Rudimentary10471 Unossified mandibleMaxilla 10472 Absent maxilla Agenesis, Aplastic10473 Fused maxilla Specify structures that arefused10474 Incomplete ossification Reduced ossificationof maxilla10475 Misshapen maxilla Abnormally shaped,Irregularly shaped10476 Small maxilla Hypoplastic, Reduced,Rudimentary10477 Unossified maxillaNasal 10478 Absent nasal Agenesis, Aplastic10479 Fused nasal Specify structures that arefused10480 Incomplete ossification Reduced ossificationof nasal10481 Misshapen nasal Abnormally shaped,Asymmetric, Irregularlyshaped10482 Nasal hole(s)10483 Small nasal Hypoplastic, Reduced,Rudimentary10484 Unossified nasalPalatine 10485 Absent palatine Agenesis, Aplastic944 DEVELOPMENTAL REPRODUCTIVE TOXICOLOGY: A PRACTICAL APPROACH, SECOND EDITION© 2006 by Taylor & Francis Group, LLC
Page 2 and 3: Second EditionDEVELOPMENTALandREPRO
Page 4 and 5: Published in 2006 byCRC PressTaylor
Page 6 and 7: Chapter 12Chapter 13Chapter 14Chapt
Page 8 and 9: The EditorRonald D. Hood, Ph.D., is
Page 10 and 11: Alan M. HobermanArgus ResearchHorsh
Page 12 and 13: APPENDIX ATerminology of Anatomical
Page 14 and 15: TERMINOLOGY OF ANATOMICAL DEFECTS 9
Page 24 and 25: Organ/StructureCodeNumberObservatio
Page 30 and 31: Organ/Structure10145 Ocular colobom
Page 34 and 35: Organ/StructurePulmonaryarteryPulmo
Page 42 and 43: Terminology of developmental abnorm
Page 54 and 55: Organ/StructureCervicalcentrumCodeN
Page 56 and 57: Organ/Structure10689 Misshapen thor
Page 58 and 59: Organ/StructureSacralcentrumSacralv
Page 68 and 69: 968 DEVELOPMENTAL REPRODUCTIVE TOXI
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994 DEVELOPMENTAL REPRODUCTIVE TOXI
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1000 DEVELOPMENTAL REPRODUCTIVE TOX
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Table 1Human Non-human Primate Rat
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Table 1 (continued)Sertoli CellsHum
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Table 2 (continued) Landmarks in th
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Table 2 (continued) Landmarks in th
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POSTNATAL DEVELOPMENTAL MILESTONES
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PART IPrinciples and Mechanisms© 2
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4 DEVELOPMENTAL REPRODUCTIVE TOXICO
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10 DEVELOPMENTAL REPRODUCTIVE TOXIC
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Table 2.6Receptor(Official Name a )
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Clearly, more research needs to be
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CHAPTER 6Comparative Features of Ve
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COMPARATIVE FEATURES OF VERTEBRATE
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Table 6.2Comparative reproductive a
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Maturation andRelease ofGametesSper
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Amniotic cavity 9.5 1.5 1-4 1-4,6,9
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Posteriorcardinal veinsestablishedT
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PosteriorcardinaldegenerationRight
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StomachappearsThirdpharyngealpouch;
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Table 6.6DescriptionComparative ges
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ParathyroidParathyroids 12.5 6.2 41
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Table 6.8DescriptionComparative ges
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Formation ofchoroid plexusof latera
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Optic nervefibers presentDifferenti
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Table 6.10DescriptionMuscular Syste
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Distalphalanges offingersseparatedF
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Table 6.11DescriptionIntermediateme
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Table 6.12DescriptionComparative ge
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CHAPTER 7Developmental Toxicity Tes
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DEVELOPMENTAL TOXICITY TESTING —
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Female 0.00-0.69 0.004-0.39 0.00-0.
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Figure 8.11775Pott DescribesScrotal
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The underlying physiology of juveni
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Table 8.5Total body composition by
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Table 8.6Serum chemistry values for
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Table 8.7Parameter bHematology valu
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CHAPTER 9Significance, Reliability,
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DEVELOPMENTAL AND REPRODUCTIVE TOXI
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Prior to the early 1980s, numerous
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Figure 9.51906Food andDrugs Act2000
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Table 9.18Selected comparison point
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Table 9.33Selected comparison point
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Table 9.48What do regulatorswant to
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CHAPTER 10Testing for Reproductive
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TESTING FOR REPRODUCTIVE TOXICITY 4
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CHAPTER 12Role of Xenobiotic Metabo
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ROLE OF XENOBIOTIC METABOLISM IN DE
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y ESR spectrometry. 122 Further ESR
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CHAPTER 13Use of Toxicokinetics in
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USE OF TOXICOKINETICS IN DEVELOPMEN
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CHAPTER 17Statistical Analysis for
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STATISTICAL ANALYSIS FOR DEVELOPMEN
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CHAPTER 19Perspectives on the Devel
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PERSPECTIVES ON THE DEVELOPMENTAL A
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Guideline OECD 415 (One Generation)
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The Office of Prevention, Pesticide
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CHAPTER 20Human Studies — Epidemi
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HUMAN STUDIES 801I. INTRODUCTIONEpi
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HUMAN STUDIES 803is actively trying
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HUMAN STUDIES 811from monstrous, us
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HUMAN STUDIES 837with spina bifida
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CHAPTER 21Developmental and Reprodu
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There are six factors that may affe
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