A Practical Approach, Second Edition=Ronald D. Ho.pdf

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Organ/StructureCodeNumberObservationSynonym orRelated TermNon-preferredTerm Definition Note10355 Small bladder Hypoplastic, Reduced,RudimentaryUreter 10356 Absent ureter Agenesis, Aplastic10357 Convoluted ureter Coiled, Folded, Kinked,Folded, curved, and/or tortuous windingsTwisted10358 Dilated ureter Bulbous, Distended Slight or moderate distention of ureter(s)10359 Doubled ureter10360 Hydroureter Markedly dilated ureter(s) Compare to Dilated; mayaccompanyhydronephrosis10361 Retrocaval ureter Passing dorsally to the vena cavaGonad 10362 Absent gonads Agenesis, Agonad,Aplastic10363 Hermaphroditism Hermaphrodism Presence of both male and femalegonadal tissue10364 Small gonad Hypoplastic, Reduced,RudimentaryUsed when sex can not bedeterminedUsed when sex can not bedetermined10365 Supernumerary gonad Additional, Extra Used when sex can not bedeterminedTestis 10366 Anorchia Agenesis, Aplastic Absence of a testis If both gonads are absentuse “Absent gonad”10367 Enlarged testis10368 Hemorrhagic testis10369 Malpositioned testis Displaced, Ectopic Cryptorchidism Cryptorchidism =testis(es) neverdescended into scrotum10370 Misshapen testis Abnormally shaped,Irregularly shaped10371 Small testis Hypoplastic, Microrchidia,Reduced, Rudimentary10372 Supernumerary testis Additional, ExtraEpididymis 10373 Absent epididymis Agenesis, Aplastic10374 Hemorrhagicepididymis10375 MalpositionedDisplaced, Ectopicepididymis10376 Short epididymis Rudimentary10377 Small epididymis Hypoplastic, Reduced,RudimentaryVasdeferens10378 Absent vas deferens Agenesis, AplasticTERMINOLOGY OF ANATOMICAL DEFECTS 939© 2006 by Taylor & Francis Group, LLC
Terminology of developmental abnormalities in common laboratory mammals (version 1): Visceral abnormalities 1 (continued)Region/Organ/StructureCodeNumberObservation10379 Atresia of vas deferens Imperforate10380 Malpositioned vas Displaced, Ectopicdeferens10381 Short vas deferens RudimentaryOvary 10382 Absent ovary Agenesis, Aplastic If both gonads are absentuse Absent gonads10383 Cyst on ovary10384 Enlarged ovary10385 Hemorrhagic ovary Oophorrhagia10386 Malpositioned ovary Displaced, Ectopic10387 Misshapen ovary Abnormally shaped,Irregularly shaped10388 Small ovary Hypoplastic, Reduced,Rudimentary10389 Supernumerary ovary Additional, ExtraOviduct 10390 Absent oviduct Agenesis, Aplastic10391 Cyst on oviduct10392 Enlarged oviduct10393 Hemorrhagic oviduct10394 Malpositioned oviduct Displaced, Ectopic10395 Misshapen oviduct Abnormally shaped,Irregularly shaped10396 Short oviduct RudimentaryUterus 10397 Absent uterine horn Agenesis, Ametria,AplasticAbsence of one uterine hornUse Absent uterus if bothhorns are absent10398 Atresia of uterus Hysteratresia, Imperforate Specify total or partial10399 Hemorrhagic uterus10400 Misshapen uterus Abnormally shaped,Irregularly shaped10401 Small uterus Hypoplastic, Reduced,Rudimentary1For terms in brackets, see Appendix 1-B.Synonym orRelated TermNon-preferredTerm Definition Note940 DEVELOPMENTAL REPRODUCTIVE TOXICOLOGY: A PRACTICAL APPROACH, SECOND EDITION© 2006 by Taylor & Francis Group, LLC
Page 2 and 3: Second EditionDEVELOPMENTALandREPRO
Page 4 and 5: Published in 2006 byCRC PressTaylor
Page 6 and 7: Chapter 12Chapter 13Chapter 14Chapt
Page 8 and 9: The EditorRonald D. Hood, Ph.D., is
Page 10 and 11: Alan M. HobermanArgus ResearchHorsh
Page 12 and 13: APPENDIX ATerminology of Anatomical
Page 14 and 15: TERMINOLOGY OF ANATOMICAL DEFECTS 9
Page 24 and 25: Organ/StructureCodeNumberObservatio
Page 30 and 31: Organ/Structure10145 Ocular colobom
Page 34 and 35: Organ/StructurePulmonaryarteryPulmo
Page 42 and 43: Terminology of developmental abnorm
Page 54 and 55: Organ/StructureCervicalcentrumCodeN
Page 56 and 57: Organ/Structure10689 Misshapen thor
Page 58 and 59: Organ/StructureSacralcentrumSacralv
Page 68 and 69: 968 DEVELOPMENTAL REPRODUCTIVE TOXI
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990 DEVELOPMENTAL REPRODUCTIVE TOXI
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1000 DEVELOPMENTAL REPRODUCTIVE TOX
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Table 1Human Non-human Primate Rat
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Table 1 (continued)Sertoli CellsHum
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Table 2 (continued) Landmarks in th
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Table 2 (continued) Landmarks in th
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POSTNATAL DEVELOPMENTAL MILESTONES
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PART IPrinciples and Mechanisms© 2
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4 DEVELOPMENTAL REPRODUCTIVE TOXICO
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10 DEVELOPMENTAL REPRODUCTIVE TOXIC
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Table 2.6Receptor(Official Name a )
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Clearly, more research needs to be
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CHAPTER 6Comparative Features of Ve
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COMPARATIVE FEATURES OF VERTEBRATE
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Table 6.2Comparative reproductive a
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Maturation andRelease ofGametesSper
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Amniotic cavity 9.5 1.5 1-4 1-4,6,9
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Posteriorcardinal veinsestablishedT
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PosteriorcardinaldegenerationRight
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StomachappearsThirdpharyngealpouch;
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Table 6.6DescriptionComparative ges
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ParathyroidParathyroids 12.5 6.2 41
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Table 6.8DescriptionComparative ges
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Formation ofchoroid plexusof latera
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Optic nervefibers presentDifferenti
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Table 6.10DescriptionMuscular Syste
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Distalphalanges offingersseparatedF
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Table 6.11DescriptionIntermediateme
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Table 6.12DescriptionComparative ge
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CHAPTER 7Developmental Toxicity Tes
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DEVELOPMENTAL TOXICITY TESTING —
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Female 0.00-0.69 0.004-0.39 0.00-0.
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Figure 8.11775Pott DescribesScrotal
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The underlying physiology of juveni
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Table 8.5Total body composition by
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Table 8.6Serum chemistry values for
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Table 8.7Parameter bHematology valu
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CHAPTER 9Significance, Reliability,
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DEVELOPMENTAL AND REPRODUCTIVE TOXI
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Prior to the early 1980s, numerous
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Figure 9.51906Food andDrugs Act2000
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Table 9.18Selected comparison point
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Table 9.33Selected comparison point
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Table 9.48What do regulatorswant to
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CHAPTER 10Testing for Reproductive
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TESTING FOR REPRODUCTIVE TOXICITY 4
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We would like to acknowledge the ef
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CHAPTER 12Role of Xenobiotic Metabo
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ROLE OF XENOBIOTIC METABOLISM IN DE
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y ESR spectrometry. 122 Further ESR
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CHAPTER 13Use of Toxicokinetics in
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USE OF TOXICOKINETICS IN DEVELOPMEN
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CHAPTER 17Statistical Analysis for
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STATISTICAL ANALYSIS FOR DEVELOPMEN
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CHAPTER 19Perspectives on the Devel
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PERSPECTIVES ON THE DEVELOPMENTAL A
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Guideline OECD 415 (One Generation)
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The Office of Prevention, Pesticide
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CHAPTER 20Human Studies — Epidemi
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HUMAN STUDIES 801I. INTRODUCTIONEpi
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HUMAN STUDIES 803is actively trying
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HUMAN STUDIES 805100908070Induced a
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HUMAN STUDIES 80940003500Mean birth
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HUMAN STUDIES 811from monstrous, us
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HUMAN STUDIES 813A distinction is s
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CHAPTER 21Developmental and Reprodu
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