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A Practical Approach, Second Edition=Ronald D. Ho.pdf

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IN VITRO METHODS FOR THE STUDY OF MECHANISMS OF DEVELOPMENTAL TOXICOLOGY 68772. Fantel, A.G., Greenaway, J.C., Juchau, M.R., and Shepard, T.H., Teratogenic bioactivation of cyclophosphamidein vitro, Life Sci., 25, 67, 1979.73. Faustman-Watts, E.M., Greenaway, J.C., Namkung, M.J., Fantel, A.G., and Juchau, M.R., Teratogenicityin vitro of 2-acetylaminofluorene: role of biotransformation in the rat, Teratology, 27, 19, 1983.74. Greenaway, J.C., Bark, D.H., and Juchau, M.R., Embryotoxic effects of salicylates: role of biotransformation,Toxicol. Appl. Pharmacol., 74, 141, 1984.75. Fantel, A.G., Greenaway, J.C. and Juchau, M.R., The embryotoxicity of adriamycin in rat embryosin vitro, Toxicol. Appl. Pharmacol., 80, 155, 1985.76. Harris, C., Stark, K.L., Luchtel, D.L. and Juchau, M.R., Abnormal neurulation induced by 7-hydroxy-2-acetylaminofluorene and acetaminophen: evidence for catechol metabolites as proximate dysmorphogens,Toxicol. Appl. Pharmacol., 101, 432, 1989.77. Steele, C.E., Marlow, R., Turton, J., and Hicks, R.M., In vitro teratogenicity of retinoids, Br. J. Exp.Path., 68, 215, 1987.78. Creech Kraft, J. and Juchau, M.R., Conceptal biotransformation of 4-oxo-all-trans-retinoic acid, 4-oxo-13-cis-retinoic acid and all-trans-retinoyl-beta-glucuronide in rat whole embryo culture, Biochem.Pharmacol., 43, 2289, 1992.79. Klug, S., Lewandowski, C., Zappel, F., merker, H.-J., Nau, H. and Neubert, D., Effects of valproicacid, some of its metabolites and analogues on prenatal development of rats in vitro and comparisonwith effects in vivo, Arch. Toxicol. 64, 545, 1990.80. Bruckner, A., Lee, Y.J., O’Shea, K.S., and Henneberry, R.C., Teratogenic effects of valproic acid anddiphenylhydantoin on mouse embryos in culture, Teratology, 27, 29, 1983.81. Fantel, A.G., Greenaway, J.C., Walker, E., and Juchau, M.R., The toxicity of niridazole in rat embryosin vitro, Teratology, 33, 105, 1986.82. Fantel, A.G., Greenaway, J.C. Shepard, T.H., Juchau, M.R., and Selleck, S.B., The teratogenicity ofcytochalasin D and its inhibition by drug metabolism, Teratology, 23, 223, 1981.83. Greenaway, J.C. and Fantel, A.G., Enhancement of rifampin teratogenicity in cultured rat embryos.Toxicol. Appl. Pharmacol., 69, 81, 1983.84. Faustman-Watts, E.M., Namkung, M.J., Greenaway, J.C. and Juchau, M.R., Analyses of metabolitesof 2-acetylaminofluorene generated in an embryo culture system: relationship of biotransformationto teratogenicity in vitro, Biochem. Pharmacol., 34, 2853, 1985.85. Yang, H.-Y.L., Namkung, M.J., and Juchau, M.R. Cytochrome P-450-dependent biotransformation ofa series of phenoxazone ethers in the rat conceptus during early organogenesis: evidence for multipleP-450 isozymes. Mol. Pharmacol., 34, 67, 1988.86. Yang, H.-Y.L., Zelus, B.D. and Juchau, M.R., Organogenesis-stage cytochrome P450 isoforms: utilizationof PCR for detection of CYP1A1 mRNA in rat conceptal tissues, Biochem. Biophys. Res.Commun., 178, 236, 1991.87. Chapman, D.E., Yang, H.Y., Watters, J.J., and Juchau, M.R., Induction in vitro and complete codingregion sequence of cytochrome P4501A1 cDNA from cultured whole rat conceptuses during earlyorganogenesis, Biochem. Pharmacol., 48, 1807, 1994.88. Martz, F., Failinger, C., III, and Blake, D.A., Phenytoin teratogenesis: correlation between embryopathiceffect and covalent binding on putative arene oxide metabolite in gestational tissue, J. Pharmacol.Exp. Ther., 203, 231, 1986.89. Wells, P.G., Zubovits, J.T., Wong, S.T., Molinari, L.M., and Ali, S., Modulation of phenytoin teratogenicityand embryonic covalent binding by the cyclooxygenase inhibitor acetylsalicylic acid, caffeicacid, and α-phenyl-N-t-butylnitrone: implications for bioactivation by prostaglandin H synthease,Toxicol. Appl. Pharmacol., 97, 192, 1989.90. Kubow, S. and Wells, P.G., In vitro bioactivation of phenytoin to a reactive free radical intermediateby prostaglandin H synthase, horseradish peroxidase, and thyroid peroxidase, Mol. Pharmacol., 35,504, 1989.91. Yu, W.K. and Wells, P.G., Evidence for lipoxygenase-catalyzed bioactivation of phenytoin to ateratogenic reactive intermediate: in vitro studies using linoleic acid-dependent soybean lipoxygenase,and in vivo studies using pregnant CD-1 mice, Toxicol. Appl. Pharmacol., 131, 1, 1995.92. Roy, S.K., Mitra, A.K., Hilbelink, D.R., Dwornik, J.J., and Kulkarni, A.P., Lipoxygenase activity inrat embryos and its potential for xenobiotic oxidation, Biol. Neonate, 63, 297, 1993.© 2006 by Taylor & Francis Group, LLC

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