A Practical Approach, Second Edition=Ronald D. Ho.pdf

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Organ/StructureCodeNumberObservationSynonym orRelated Term10188 Microcardia Hypoplastic, Reduced,Rudimentary10189 Misshapen aortic valve Abnormally shaped,Irregularly shaped10190 Misshapen left A-V Abnormally shaped,valveIrregularly shaped10191 Misshapen pulmonic Abnormally shaped,valveIrregularly shaped10192 Misshapen right A-V Abnormally shaped,valveIrregularly shapedNon-preferredTerm Definition NoteSmall heartUsed in absence ofstructural changesIncludes alterations innumber of cuspsA-V = atrioventricularIncludes alterations innumber of cuspsIncludes alterations innumber of cusps.A-V=atrioventricular[Tetralogy of Fallot]10193 Muscular ventricularseptum defectMuscular VSDAn opening in the muscular septumbetween the ventricles10194 Persistent A-V canal Defects of endocardial cushionsA-V = atrioventricularresulting in low atrial and highventricular septal defects10195 Small aortic valve Hypoplastic, Reduced,Rudimentary10196 Small left A-V valve Hypoplastic, Reduced,A-V = atrioventricularRudimentary10197 Small pulmonic valve Hypoplastic, Reduced,Rudimentary10198 Small right A-V valve Hypoplastic, Reduced,A-V = atrioventricularRudimentary10199 Small ventricular Hypoplastic, Reduced,chamberRudimentaryAorta 10200 Aortic atresia Imperforate Absence of patent communicationbetween the ascending aorta and theventricular mass which is usuallygrossly hypoplastic10201 Dilated aorta Bulbous10202 Double aorta10203 Malpositioned aorta Displaced, Ectopic10204 Narrowed aorta Coarctation, Constricted,Stenosis, Stricture10205 Overriding aorta Biventricular origin of aorta [Tetralogy of Fallot]Aortic arch 10206 Aortic arch atresia Imperforate10207 Dilated aortic arch Bulbous10208 Interrupted aortic arch Ascending aorta not connected todescending aorta10209 Narrowed aortic arch Coarctation, Constricted,Stenosis, StrictureTERMINOLOGY OF ANATOMICAL DEFECTS 931© 2006 by Taylor & Francis Group, LLC
Terminology of developmental abnormalities in common laboratory mammals (version 1): Visceral abnormalities 1 (continued)Region/Organ/StructureCarotidarteryDuctusarteriosusGreatvesselsInnominatearteryCodeNumberObservationSynonym orRelated Term10210 Retroesophageal aorticarch10211 Right-sided aortic arch10212 Absent carotid Agenesis, Aplastic10213 Dilated carotid Bulbous10214 Malpositioned carotid Displaced, EctopicbranchNon-preferredTerm Definition NoteIncludes right carotidoriginating from aorta(i.e., no innominate)10215 Narrowed carotid Coarctation, Constricted,Stenosis, Stricture10216 Retroesophagealcarotid10217 Absent ductusAgenesis, Aplasticarteriosus10218 Dilated ductusBulbousarteriosus10219 Malpositioned ductus Displaced, Ectopicarteriosus10220 Narrowed ductus Coarctation, Constricted,Normal occurrence afterarteriosusStenosis, Stricturebirth10221 Patent ductusPersistentOpen and unobstructed ductusNormal only in fetal periodarteriosusarteriosus postnatally10222 A-P septum defect Communication between ascending A-P = Aorticopulmonaryaorta and pulmonary trunk10223 Persistent truncus Truncus arteriosusA common aortic and pulmonary truncusarteriosuscommunis10224 Transposition of greatOrigin of aorta from right ventricle andvesselspulmonary trunk from left ventricle10225 Dilated innominate Bulbous Also known as brachiocephalic trunk10226 Elongated innominate Also known as brachiocephalic trunk10227 MalpositionedDisplaced, EctopicAlso known as brachiocephalic trunkinnominate10228 Narrowed innominate Coarctation, Constricted,Stenosis, StrictureAlso known as brachiocephalic trunk932 DEVELOPMENTAL REPRODUCTIVE TOXICOLOGY: A PRACTICAL APPROACH, SECOND EDITION© 2006 by Taylor & Francis Group, LLC
Page 2 and 3: Second EditionDEVELOPMENTALandREPRO
Page 4 and 5: Published in 2006 byCRC PressTaylor
Page 6 and 7: Chapter 12Chapter 13Chapter 14Chapt
Page 8 and 9: The EditorRonald D. Hood, Ph.D., is
Page 10 and 11: Alan M. HobermanArgus ResearchHorsh
Page 12 and 13: APPENDIX ATerminology of Anatomical
Page 14 and 15: TERMINOLOGY OF ANATOMICAL DEFECTS 9
Page 24 and 25: Organ/StructureCodeNumberObservatio
Page 30 and 31: Organ/Structure10145 Ocular colobom
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Page 42 and 43: Terminology of developmental abnorm
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Page 56 and 57: Organ/Structure10689 Misshapen thor
Page 58 and 59: Organ/StructureSacralcentrumSacralv
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982 DEVELOPMENTAL REPRODUCTIVE TOXI
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1000 DEVELOPMENTAL REPRODUCTIVE TOX
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Table 1Human Non-human Primate Rat
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Table 1 (continued)Sertoli CellsHum
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Table 2 (continued) Landmarks in th
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Table 2 (continued) Landmarks in th
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POSTNATAL DEVELOPMENTAL MILESTONES
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PART IPrinciples and Mechanisms© 2
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4 DEVELOPMENTAL REPRODUCTIVE TOXICO
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10 DEVELOPMENTAL REPRODUCTIVE TOXIC
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Table 2.6Receptor(Official Name a )
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Clearly, more research needs to be
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CHAPTER 6Comparative Features of Ve
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COMPARATIVE FEATURES OF VERTEBRATE
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Table 6.2Comparative reproductive a
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Maturation andRelease ofGametesSper
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Amniotic cavity 9.5 1.5 1-4 1-4,6,9
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Posteriorcardinal veinsestablishedT
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PosteriorcardinaldegenerationRight
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StomachappearsThirdpharyngealpouch;
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Table 6.6DescriptionComparative ges
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ParathyroidParathyroids 12.5 6.2 41
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Table 6.8DescriptionComparative ges
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Formation ofchoroid plexusof latera
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Optic nervefibers presentDifferenti
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Table 6.10DescriptionMuscular Syste
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Distalphalanges offingersseparatedF
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Table 6.11DescriptionIntermediateme
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Table 6.12DescriptionComparative ge
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CHAPTER 7Developmental Toxicity Tes
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DEVELOPMENTAL TOXICITY TESTING —
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Female 0.00-0.69 0.004-0.39 0.00-0.
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Figure 8.11775Pott DescribesScrotal
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The underlying physiology of juveni
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Table 8.5Total body composition by
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Table 8.6Serum chemistry values for
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Table 8.7Parameter bHematology valu
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CHAPTER 9Significance, Reliability,
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DEVELOPMENTAL AND REPRODUCTIVE TOXI
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Prior to the early 1980s, numerous
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Figure 9.51906Food andDrugs Act2000
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Table 9.18Selected comparison point
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Table 9.33Selected comparison point
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Table 9.48What do regulatorswant to
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CHAPTER 10Testing for Reproductive
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TESTING FOR REPRODUCTIVE TOXICITY 4
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We would like to acknowledge the ef
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CHAPTER 12Role of Xenobiotic Metabo
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ROLE OF XENOBIOTIC METABOLISM IN DE
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y ESR spectrometry. 122 Further ESR
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CHAPTER 13Use of Toxicokinetics in
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USE OF TOXICOKINETICS IN DEVELOPMEN
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CHAPTER 17Statistical Analysis for
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STATISTICAL ANALYSIS FOR DEVELOPMEN
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CHAPTER 19Perspectives on the Devel
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PERSPECTIVES ON THE DEVELOPMENTAL A
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Guideline OECD 415 (One Generation)
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The Office of Prevention, Pesticide
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CHAPTER 20Human Studies — Epidemi
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HUMAN STUDIES 801I. INTRODUCTIONEpi
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HUMAN STUDIES 803is actively trying
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HUMAN STUDIES 805100908070Induced a
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HUMAN STUDIES 80940003500Mean birth
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HUMAN STUDIES 811from monstrous, us
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HUMAN STUDIES 829B. The Formation o
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HUMAN STUDIES 837with spina bifida
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CHAPTER 21Developmental and Reprodu
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There are six factors that may affe
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