Synthesis and Comparison of the Reactivity of Allyl Fluorides and ...

More documents

Recommendations

Info

33 Chapter One [52] W. S. Johnson, R. A. Buchanan, W. R. Bartlett, F. S. Tham, R. K. Kullnig, J. Am. Chem. Soc. 1993, 115, 504. [53] W. S. Johnson, V. R. Fletcher, B. Chenera, W. R. Bartlett, F. S. Tham, R. K. Kullnig, J. Am. Chem. Soc. 1993, 115, 497. [54] W. S. Johnson, B. Chenera, F. S. Tham, R. K. Kullnig, J. Am. Chem. Soc. 1993, 115, 493. [55] J. Murata, M. Tamura, A. Sekiya, Green Chem. 2002, 4, 60. [56] T. Hanamoto, S. Harada, K. Shindo, M. Kondo, Chem. Commun. 1999, 2397. [57] G. D. Crouse, J. D. Webster, J. Org. Chem. 1992, 57, 6643. [58] T. Hanamoto, K. Shindo, M. Matsuoka, Y. Kiguchi, M. Kondo, J. Chem. Soc., Perkin Trans. 1 2000, 103. [59] X. Yue, X. Zhang, F. L. Qing, Org. Lett. 2009, 11, 73. [60] W. J. Middleton, J. Org. Chem. 1975, 40, 574. [61] Y.-Y. Wu, X. Zhang, W. D. Meng, F. L. Qing, Org. Lett. 2004, 6, 3941. [62] Z.-Y. Yang, D. J. Burton, J. Fluorine Chem. 1989, 44, 339. [63] Z.-Y. Yang, D. J. Burton, J. Org. Chem. 1991, 56, 1037. [64] D. Seyferth, R. M. Simon, D. J. Sepelak, H. A. Klein, J. Org. Chem. 1980, 45, 2273. [65] D. Seyferth, R. M. Simon, D. J. Sepelak, H. A. Klein, J. Am. Chem. Soc. 1983, 105, 4634. [66] D. Seyferth, K. R. Wursthorn, J. Organomet. Chem. 1979, 182, 455. [67] N. Boyer, P. Gloanec, G. De Nanteuil, P. Jubault, J.-C. Quirion, Eur. J. Org. Chem. 2008, 4277. [68] E. Juaristi, D. Quintana, J. Escalante, Aldrichim. Acta 1994, 27, 3. [69] T. C. Boge, G. I. Georg, Enantioselective Synthesis of �-amino acids Wiley-VCH, New York, 1996. [70] J. J. McAtee, R. F. Schinazi, D. C. Liotta, J. Org. Chem. 1998, 63, 2161. [71] P. Lin, J. Jiang, Tetrahedron 2000, 56, 3635. [72] N. Reineke, N. A. Zaidi, M. Mitra, D. O'Hagan, A. S. Batsanov, J. A. K. Howard, D. Y. Naumov, J. Chem. Soc. Perkin Trans. 1 1996, 147. [73] T. Saeki, Y. Takashima, K. Tamao, Synlett 2005, 1771. [74] K. Manabe, S. Ishikawa, Synthesis 2008, 2645. [75] D. W. Robertson, J. H. Krushinski, R. W. Fuller, J. D. Leander, J. Med. Chem. 1988, 31, 1418. [76] J. Ichikawa, Y. Wada, M. Fujisawa, K. Sakoda, Synthesis 2002, 1917. [77] S. Yamada, T. Takahashi, T. Konno, T. Ishihara, Chem. Commun. 2007, 3679. [78] Y. Yamauchi, T. Fukuhara, S. Hara, H. Senboku, Synlett 2008, 438.
[79] M. Schlosser, D. Michael, Z.-W. Guo, C. J. Sih, Tetrahedron 1996, 52, 8257. [80] F. Bellezza, A. Cipiciani, G. Ricci, R. Ruzziconi, Tetrahedron 2005, 8005. 34 Chapter One [81] H. Fujisawa, T. Fujiwara, Y. Takeuchi, K. Omata, Chem. Pharm. Bull. 2005, 53, 524. [82] T. Miura, Y. Ito, M. Murakami, Chem. Lett. 2008, 37, 1006. [83] M. Hudlicky, J. Fluorine Chem 1989, 44, 345. [84] T. Narumi, K. Tomita, E. Inokuchi, K. Kobayashi, S. Oishi, H. Ohno, N. Fujii, Org. Lett. 2007, 9, 3465. [85] G. Dutheuil, S. Couve-Bonnaire, X. Pannecoucke, Angew. Chem., Int. Ed. Engl. 2007, 46, 1290. [86] T. Narumi, A. Niida, K. Tomita, S. Oishi, A. Otaka, H. Ohno, N. Fujii, Chem. Commun. 2006, 4720. [87] Y. Nakamura, M. Okada, A. Sato, H. Horikawa, M. Koura, A. Saito, T. Taguchi, Tetrahedron 2005, 61, 5741. [88] T. Allmendinger, E. Felder, E. Hungerbuhler, Tetrahedron Lett. 1990, 31, 7301. [89] P. Bey, J. R. McCarthy, I. A. McDonald, ACS Symp. Ser. 1991, 456, 105. [90] O. Yokokoji, T. Shimizu, S. Kumai, Chem. Abstr. 1996, 124, 316586.
Page 1 and 2: Synthesis and Comparison of the Rea
Page 3 and 4: Acknowledgements Firstly, I would l
Page 5 and 6: 2.2.2.1.1 Synthesis of 1-(Benzyloxy
Page 7 and 8: 6.2.12 Preparation of 2-(4-trimethy
Page 9 and 10: 6.4.12 Experimental Data for Dimeth
Page 11 and 12: AgF ap Bn Bz CsF d DAST dba DCM DME
Page 13 and 14: Chapter one
Page 15 and 16: 2 Chapter One potentially explosive
Page 17 and 18: 4 Chapter One ortho-biphenyl trifla
Page 19 and 20: 6 Chapter One 2,10 (3,3-dichlorocam
Page 21 and 22: 8 Chapter One both enantiomers were
Page 23 and 24: 10 Chapter One poor to moderate ena
Page 25 and 26: Scheme 1.10 Fluorination of (17) 12
Page 27 and 28: 14 Chapter One fluorine donors, Lew
Page 29 and 30: 1.3 Enantioselective Nucleophilic F
Page 31 and 32: Scheme 1.16 Fluorination of (32) 18
Page 33 and 34: 20 Chapter One (iii) SN2’ type su
Page 35 and 36: 22 Chapter One cytotoxicity in the
Page 37 and 38: 24 Chapter One Manabe and Ishikawa
Page 39 and 40: Scheme 1.25 Synthesis of (41)-(44)
Page 41 and 42: Figure 1.12 �-fluorinated NSAIDs
Page 43 and 44: 1.6 Thesis Outline 30 Chapter One T
Page 45: 32 Chapter One [26] M. Abdul-Ghani,
Page 49 and 50: 2.1 Introduction 2 Synthesis of All
Page 51 and 52: 37 Chapter Two In dehydroxyfluorina
Page 53 and 54: Scheme 2.6 Fluorination with IF5/Et
Page 55 and 56: 41 Chapter Two desired allylic fluo
Page 57 and 58: 43 Chapter Two c) Formation of a su
Page 59 and 60: Scheme 2.14 Reaction of cis-3-methy
Page 61 and 62: Substrate (60) (61) (62) (63) R = O
Page 63 and 64: Alcohol Product Yield (%) Table 2.7
Page 65 and 66: 51 Chapter Two completion. This ena
Page 67 and 68: 53 Chapter Two Chapter Three. Follo
Page 69 and 70: 55 Chapter Two Two allyl alcohols w
Page 71 and 72: 57 Chapter Two The conversion of (8
Page 73 and 74: Starting substrate (88) (89) (90) (
Page 75 and 76: Starting substrate (99) (76) (77) (
Page 77 and 78: 63 Chapter Two Both (105) and (104)
Page 79 and 80: Scheme 2.25 Mechanistic pathway for
Page 81 and 82: 2.3 Conclusions 67 Chapter Two The
Page 83 and 84: [28] D. F. Taber, J. Am. Chem. Soc.
Page 85 and 86: Chapter THRee
Page 87 and 88: 72 Chapter Three Kurosawa reacted a
Page 89 and 90: 74 Chapter Three These results demo
Page 91 and 92: 76 Chapter Three More recently, wor
Page 93 and 94: 3.2 Results and Discussion 3.2.1 Re
Page 95 and 96: 80 Chapter Three Starting substrate
Page 97 and 98:
82 Chapter Three Figure 3.4 Crystal
Page 99 and 100:
Scheme 3.12 Oxidative addition of 1
Page 101 and 102:
86 Chapter Three when the reaction
Page 103 and 104:
88 Chapter Three Therefore, from th
Page 105 and 106:
-140 -140 -140 -140 -140 -150 -150
Page 107 and 108:
92 Chapter Three monitored for 80 m
Page 109 and 110:
3.4 References [1] W. T. Dent, R. L
Page 111 and 112:
Chapter Four
Page 113 and 114:
97 Chapter Four nucleophilic substi
Page 115 and 116:
99 Chapter Four Further reactions w
Page 117 and 118:
Figure 4.3 Structure of co-product
Page 119 and 120:
4.2.2 Reactions of palladium cation
Page 121 and 122:
105 Chapter Four substituents on th
Page 123 and 124:
107 Chapter Four The desired produc
Page 125 and 126:
109 Chapter Four The reaction of (1
Page 127 and 128:
111 Chapter Four were both reacted
Page 129 and 130:
[28] D. Landini, A. Maia, A. Rampol
Page 131 and 132:
5.1 Introduction 5 Synthesis and Re
Page 133 and 134:
116 Chapter Five The first enantios
Page 135 and 136:
118 Chapter Five Gem(difluoroallyl)
Page 137 and 138:
120 Chapter Five benzaldehyde, 3-br
Page 139 and 140:
Starting Substrate (76) (77) (78) (
Page 141 and 142:
Starting Substrate Product Yield (%
Page 143 and 144:
5.2.4 Synthesis of Allylic Difluori
Page 145 and 146:
5.2.5 Metal-mediated synthesis of 3
Page 147 and 148:
130 Chapter Five process. [40] Unfo
Page 149 and 150:
132 Chapter Five compounds were pur
Page 151 and 152:
134 Chapter Five [30] H. L. Sham, N
Page 153 and 154:
6.1 General Experimental Procedures
Page 155 and 156:
6.2 Experimental Details for Chapte
Page 157 and 158:
139 Chapter Six (1 g, 0.75 cm 3 , 6
Page 159 and 160:
6.2.7 Preparation of allyl 4-(trifl
Page 161 and 162:
6.2.10 Preparation of (3-[1,3]Dioxa
Page 163 and 164:
145 Chapter Six reaction mixture wa
Page 165 and 166:
147 Chapter Six mg, 1.1 mmol), ally
Page 167 and 168:
149 Chapter Six 260.3 Hz, ArCF), 16
Page 169 and 170:
6.2.22 Preparation of 2-fluorobut-3
Page 171 and 172:
6.2.25 Preparation of 2-fluorobut-3
Page 173 and 174:
6.2.28 Preparation of 2-hydroxybut-
Page 175 and 176:
157 Chapter Six 1 JCF = 253.5 Hz, A
Page 177 and 178:
159 Chapter Six drying under high v
Page 179 and 180:
6.2.37 Preparation of 2-chlorobut-3
Page 181 and 182:
6.2.40 Preparation of 2-chlorobut-3
Page 183 and 184:
6.3.2 Preparation of Bis[�-chloro
Page 185 and 186:
167 Chapter Six 6.3.5 Preparation o
Page 187 and 188:
169 Chapter Six 4 JHH = 1.2 Hz, ArH
Page 189 and 190:
Time (minutes) 4 11 18 25 Table 6.2
Page 191 and 192:
Time (minutes) 19 F{ 1 H} (ppm) Tim
Page 193 and 194:
175 Chapter Six suspension of sodiu
Page 195 and 196:
177 Chapter Six Hz, Ha), 5.19 (1H,
Page 197 and 198:
6.4.9 Preparation of Dimethyl 2-(4-
Page 199 and 200:
181 Chapter Six 6.4.13 Preparation
Page 201 and 202:
6.5 Experimental Details for Chapte
Page 203 and 204:
185 Chapter Six CHCH2), 133.9 (d, 3
Page 205 and 206:
187 Chapter Six 6.5.6 Preparation o
Page 207 and 208:
189 Chapter Six (5 mg, 0.27 mmol) a
Page 209 and 210:
191 Chapter Six (d, 1 JCF = 255.0 H
Page 211 and 212:
193 Chapter Six layer separated and
Page 213 and 214:
195 Chapter Six Hz, 4 JHF = 3.2 Hz,
Page 215 and 216:
Page 217 and 218:
Page 219 and 220:
Appendix
Page 221 and 222:
II Appendix Second generation Grubb
Page 223 and 224:
IV Appendix mixture was stirred at
Page 225 and 226:
VI Appendix stirred at room tempera
Page 227 and 228:
VIII Appendix The organic phase was
Page 229 and 230:
X Appendix A6 Crystal data and stru
Page 231 and 232:
XII Appendix A8 Crystal data and st
Page 233 and 234:
XIV Appendix A10 Crystal data and s
Page 235 and 236:
A12 Lecture Courses Attended XVI Ap
Page 237 and 238:
A14 Conferences Attended RSC Organi
show all

Synthesis and Comparison of the Reactivity of Allyl Fluorides and ...

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?