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Advisory Committee on Pesticides Annual Report 2001

ACP Annual Report 2001 - Pesticides Safety Directorate

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<str<strong>on</strong>g>Advisory</str<strong>on</strong>g> <str<strong>on</strong>g>Committee</str<strong>on</strong>g> <strong>on</strong> <strong>Pesticides</strong> <strong>Annual</strong> <strong>Report</strong> <strong>2001</strong><br />

Appendix VI:<br />

Terms and abbreviati<strong>on</strong>s<br />

104<br />

ACP<br />

Adenoma<br />

ADI<br />

Aneugenic<br />

Aneuploidy<br />

AOEL<br />

BCF<br />

bw<br />

d<br />

CAP<br />

Carcinogens<br />

<str<strong>on</strong>g>Advisory</str<strong>on</strong>g> <str<strong>on</strong>g>Committee</str<strong>on</strong>g> <strong>on</strong> <strong>Pesticides</strong><br />

a benign tumour with a gland-like structure or developed from<br />

the glandular epithelium<br />

acceptable daily intake, defined as ’an estimate of the amount<br />

of a substance, expressed <strong>on</strong> a bodyweight basis, that can be<br />

ingested daily over a lifetime without appreciable health risk’<br />

inducing aneuploidy (q.v.)<br />

the circumstances in which the total number of chromosomes<br />

within a cell is not an exact multiple of the normal haploid<br />

(see polyploidy) number. Chromosomes may be lost or gained<br />

during cell divisi<strong>on</strong><br />

acceptable operator exposure level<br />

bioc<strong>on</strong>centrati<strong>on</strong> factor<br />

bodyweight<br />

day<br />

Comm<strong>on</strong> Agricultural Policy<br />

the causal agents which induce tumours. They include external<br />

factors (chemicals, physical agents, viruses) and internal factors<br />

such as horm<strong>on</strong>es. Chemical carcinogens are structurally diverse<br />

and include naturally occurring substances as well as synthetic<br />

compounds. An important distincti<strong>on</strong> can be drawn between<br />

genotoxic (q.v.) carcinogens, which have been shown to react<br />

directly with and mutate DNA, and n<strong>on</strong>-genotoxic carcinogens,<br />

which act through other mechanisms. The activity of genotoxic<br />

carcinogens can often be predicted from their chemical<br />

structure. Most chemical carcinogens exert their effects after<br />

prol<strong>on</strong>ged exposure, show a dose-resp<strong>on</strong>se relati<strong>on</strong>ship and<br />

tend to act <strong>on</strong> a limited range of susceptible target tissues.<br />

Carcinogens are sometimes species- or sex-specific. Several<br />

different chemical and other carcinogens may interact and

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