Advisory Committee on Pesticides Annual Report 2001

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Section E: UK Review Programme 3-iodo-2-propynyl-N-butyl carbamate is a carbamate compound that has weak anticholinesterase activity. DO NOT USE if under medical advice not to work with anticholinesterase compounds. Having been informed that the ACP had rejected its case for removal of the original label, and recommended that an alternative phrase must be used, the company asked the ACP whether it could continue to use the original rather than the alternative phrase. The company stated that, since the new phrase was unique to IPBC, introducing it would risk confusion and uncertainty among its customers. It was also reluctant to have its clients reprint labels when further changes might be necessary on completion of the review. The <strong>Committee</strong> agreed to this request. Azamethiphos Azamethiphos is an organophosphorus compound approved for use both as an agricultural and non-agricultural insecticide. It is one of the chemicals in the current UK review of organophosphorous and carbamate compounds. At the time of the review there were two approved non-agricultural pesticide products containing azamethiphos. These were impregnated bait stickers for application to hard surfaces by non-professional users. 53 A human health review of the agricultural uses of azamethiphos had previously been considered by the ACP earlier in the year. The supplier was common to both agricultural and non-agricultural uses and therefore its physical chemistry and mammalian toxicology data had already been considered (see page 41). The <strong>Committee</strong> examined additional published toxicology data and considered the human health and efficacy issues associated with the non-agricultural uses of azamethiphos. Results obtained from a storage stability study for one of the products showed a significant loss of azamethiphos over a two-week period. The <strong>Committee</strong> agreed that approval holders should be required to provide an appropriate storage stability study. The <strong>Committee</strong> was also concerned that people might wish to remove the bait stickers within the lifespan of the product, and perhaps come into contact with the remaining azamethiphos. Therefore it recommended that approval holders be required to provide information on the change in azamethiphos content with time during product use. The <strong>Committee</strong> also noted that azamethiphos was classified as a skin sensitiser and that one of the products also attracted this classification. However, there had been no reports of skin sensitisation arising from use of these products,
<strong>Advisory</strong> <strong>Committee</strong> on Pesticides Annual Report 2001 in the literature. Therefore, the <strong>Committee</strong> agreed that it had no concerns in this respect and that no further data should be required at this stage. The estimated exposures from initial handling of the product and continued residential use gave no cause for concern. The <strong>Committee</strong> considered that the assessment for continued residential exposure should assume use in at least two rooms. This did not identify any cause for concern. The acute exposure estimated to occur following accidental ingestion of the entire product by infants or children did give cause for concern. However, data from the National Poisons Information Service (NPIS) on incidents involving these products provided some reassurance that the likelihood of this occurring was low. 54 Overall, the <strong>Committee</strong> concluded that approval for the two products should continue subject to the companies redesigning products to include a mechanism to prevent skin contact when attaching them to windows, more secure adhesion to windows, both products containing a bittering agent, and information on changes in azamethiphos content during the lifetime of the product. These recommendations would ensure that the risk of acute exposure by contact or ingestion was acceptably low. Continued approval was also subject to further data requirements. CCA Copper chrome arsenic (CCA) wood preservatives contain arsenic pentoxide, hexavalent chromium (chromium trioxide or sodium dichromate) and copper (II) oxide or copper (II) sulphate. They are supplied as pastes or water-based concentrates which are diluted to between one percent and ten percent w/w total salts and used in the industrial vacuum-pressure impregnation of timber. The <strong>Committee</strong> had considered a review of the use of CCA in industrial wood preservation in September 1999. It had agreed that approval for CCA products could be allowed to continue, subject to a number of conditions and requirements, including the provision of specific environmental data. The <strong>Committee</strong> now considered the approval holders’ responses to the environmental data requirements, which had previously been considered by its Environmental Panel. The <strong>Committee</strong> agreed that the exposure scenario proposed by approval holders was an acceptable alternative to HSE’s previous exposure scenario. However, it noted that this scenario assumed good practice, of which the British Wood Preserving and Damp Proofing Association (BWPDA) voluntary code of practice was considered to be an appropriate benchmark. The <strong>Committee</strong>’s Environmental Panel had identified several
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Advisory Committee on Pesticides Annual Report 2001

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