Advisory Committee on Pesticides Annual Report 2001

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Section C: Inclusion of new active substances in Annex I of Directive 91/414/EEC The DAR had been distributed to all Member States for consideration in the EU peer review process. A number of key deficiencies and minor issues were identified that had to be addressed prior to inclusion of dimethenamid-P in Annex 1 of Directive 91/414 EEC. The ACP considered the DAR and draft comments prepared by PSD. The key concern related to the data available to support the contention that activity resided solely in the P-isomer and the possibility that adjustment to the proposed ADI and AOEL could be required. The ACP agreed that the one year dog study was appropriate to set the ARfD. A further in vivo UDS study was considered unnecessary, particularly as the submitted in vitro study was negative and the dosing in the available in vivo study was acceptable. The ACP noted that metabolites M23 and M27 were mobile and persistent and might contaminate ground water. Thus evidence could be needed that these metabolites were not toxicologically relevant. The <strong>Committee</strong> commented that acceptable uses could only be achieved using large buffer zones that would currently not be acceptable in the UK. It was also noted that there was no aquatic plant risk assessment for exposure via drainflow, which would be relevant in consideration of any UK use. 35 Foramsulfuron Foramsulfuron is a new sulfonylurea herbicide. The biochemical target site is the enzyme acetolactate synthase (ALS) in the aliphatic amino acid pathway in sensitive plants. It is a new pesticide to the EU. The EU application had been evaluated by Germany, the Rapporteur Member State (RMS), and a Draft Assessment Report (DAR) prepared. The DAR assessed the product ‘Equip’, a non-aqueous oil-based suspension concentrate (SC), containing 22.5 g/l foramsulfuron and 22.5 g/l of a safener. The safener, isoxadifen-ethyl, acts by increasing foramsulfuron degradation in meristematic regions of the crop. The product is intended to control post-germination grass and dicotyledonous weed species in maize (not seed or sweet maize). No UK applications had been notified. The DAR had been distributed to all Member States for consideration in the EU peer review process. The ACP was invited to consider the DAR and provide written comments. The DAR was considered to be well produced and the toxicological end points acceptable, provided the interpretations of toxicological studies were appropriate. It was also agreed that setting an ARfD was unnecessary.
<strong>Advisory</strong> <strong>Committee</strong> on Pesticides Annual Report 2001 S-metolachlor Metolachlor belongs to the chloroacetamide class of herbicides, which inhibit germination and seedling growth via effects on cell division. It is a racemic mixture of four R and S stereoisomers. The partially resolved S-metolachlor isomeric form (>80–100 percent S form/0–20 percent R form) is considered to be a new active ingredient in the EU within the remit of EU Directive 91/414/EEC. The EU application had been evaluated by Belgium, the Rapporteur Member State (RMS), and a Draft Assessment Report (DAR) prepared. The DAR assessed the product ‘Dual Gold 960 EC’ an emulsifiable concentrate (EC) containing 960 g/l S-metolachlor used to control annual weeds in maize, sweetcorn, sorghum, beet crops, sunflower, soybean and potato in northern and southern EU Member States. There had been no applications for use of S-metolachlor in the UK, although future applications were possible. The DAR had been distributed to all Member States for consideration in the EU peer review process. 36 The ACP considered the DAR and draft comments prepared by PSD. The <strong>Committee</strong> noted that the aquatic risk was only acceptable with stipulation of a large (10–20 m) buffer zone, which would not currently be an option for UK use. Overall the <strong>Committee</strong> endorsed the critique provided by PSD.
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Advisory Committee on Pesticides Annual Report 2001

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