Advisory Committee on Pesticides Annual Report 2001

More documents

Recommendations

Info

Section B: Applications for provisional approvals for products containing new active substances were all less than 1 percent of the ADI. Hence, the long-term consumer exposure was considered acceptable. No acute reference dose was proposed, as it appeared there was negligible acute dietary risk from cyazofamid. Investigations in rats indicated that CCIM might present a greater acute dietary risk. However, it was considered that since CCIM was the primary metabolite in rat metabolism and CCIM residues in potatoes were low (less than 0.01 mg/kg), dietary exposure to CCIM would be acceptable. The applicant attributed apparent differences in the toxicity of cyazofamid and CCIM to differences in oral absorption of the two compounds. The <strong>Committee</strong> agreed a short-term systemic acceptable operator exposure level (AOEL) of 0.03 mg/kg bw/day, based on the NOAEL of 500 ppm in a 90-day rat study. This was determined on increased kidney weight, basophilic tubules and clinical chemistry changes, with a 10 per cent oral absorption correction factor and a 100-fold assessment factor. The ACP considered it unlikely that the exposure of users, workers or bystanders would exceed the AOEL. However, it was agreed that gloves should be worn when mixing/loading and during application of the product. In addition, as the product was classified as a severe eye irritant, the use of a faceshield when handling the concentrate should be required. 11 The metabolite, CTCA (4-chloro-5-p-tolylimidazole-2-carboxylic acid) was likely to be very persistent in UK soils under both aerobic and anaerobic conditions. However, it was agreed that the ecotoxicology evaluation indicated an acceptable risk to non-target species. Due to a combination of relatively high sorption and a summer application, contamination of shallow vulnerable groundwater by CTCA was considered unlikely. The ACP agreed that use of ‘Ranman’ as proposed for post-emergence treatment in potato crops did not pose any unacceptable risks to birds, aquatic life, wild mammals, bees, other terrestrial arthropods, earthworms, soil macro and micro-organisms, or to non-target flora. The <strong>Committee</strong> concluded that the submitted efficacy data showed that commercially acceptable control of foliar potato blight could be obtained if ‘Ranman’ was used as recommended. There were no adverse effects in terms of phytotoxicity or on yield or quality of yield. It was considered that there would be no unacceptable risk to following or adjacent crops. The <strong>Committee</strong> considered there was a high risk of resistance development and agreed a strategy of a maximum of six applications of ‘Ranman’ per
<strong>Advisory</strong> <strong>Committee</strong> on Pesticides Annual Report 2001 potato crop, to be delivered in tranches of three applications in alternation with fungicides from a different cross-resistance group. The <strong>Committee</strong> recommended provisional approval for ‘Ranman’ for use on potatoes under the Plant Protection Products Regulations, for three years pending the Commission decision on inclusion of cyazofamid (IKF-916) in Annex I of Council Directive 91/414/EEC. The <strong>Committee</strong> also highlighted a number of issues to be discussed as part of the European consideration. Flufenacet Flufenacet (code name FOE 5043) is the proposed name for a new oxyacetamide herbicide. The molecular mode of action of oxyacetamides is unclear but at the cellular level inhibition of cell division in root and shoot meristematic regions of plants is observed. 12 The ACP considered applications for two products, namely ‘ACH 210’ and ‘Artist’, containing flufenacet in mixture with pendimethalin and metribuzin, respectively. ‘ACH 210’ is an emulsifiable concentrate (EC) containing 60 g flufenacet/l and 300 g pendimethalin/l for use on winter wheat and barley. ‘Artist’ is a water dispersible granule (WG) containing 240 g flufenacet/kg and 175 g metribuzin/kg for use on potatoes prior to emergence of both crop and weeds. The rates of use of pendimethalin and metribuzin are within precedent of extant UK approvals. Flufenacet was also new to the European Union (EU) with France acting as the Rapporteur Member State (RMS). A different product, ‘FOE 5043 WG 60’, a WG containing 600 g flufenacet/kg for pre-emergence weed control in maize, cereals, soybean and sunflower was evaluated. A Draft Assessment Report (DAR) had been prepared and end points agreed at EU (ECCO) peer review meetings and flufenacet was being considered by the EU Scientific <strong>Committee</strong> on Plants (SCP). Although a final decision on inclusion of flufenacet in Annex I of Directive 91/414/EEC had not been made, the end point list agreed in the EU was used in the UK assessment and, along with the DAR, was appended to the UK evaluation document. Acute toxicological studies required ‘ACH 210’ to be classified as ‘Harmful if swallowed’ and ‘Irritating to skin’ and for ‘Artist’ to be classified as ‘Harmful if swallowed’. The ACP concluded that there was little evidence to suggest a potentiation of toxicological effects by the second active substance in the formulations when compared with flufenacet alone and that the effects seen in these studies on the formulated products could be attributable to high dosage.
Page 1 and 2: Department for Environment, Food an
Page 3 and 4: Department for Environment, Food an
Page 5 and 6: Advisory C
Page 19: Advisory C
Page 71 and 72:
Advisory C
Page 73 and 74:
Advisory C
Page 75 and 76:
Advisory C
Page 77 and 78:
Advisory C
Page 79 and 80:
Advisory C
Page 81 and 82:
Advisory C
Page 83 and 84:
Advisory C
Page 85 and 86:
Advisory C
Page 87 and 88:
Advisory C
Page 89 and 90:
Advisory C
Page 91 and 92:
Advisory C
Page 93 and 94:
Advisory C
Page 95 and 96:
Advisory C
Page 97 and 98:
Advisory C
Page 99 and 100:
Advisory C
Page 101 and 102:
Advisory C
Page 103 and 104:
Advisory C
Page 105 and 106:
Advisory C
Page 107 and 108:
Advisory C
Page 109 and 110:
Advisory C
Page 111 and 112:
Advisory C
Page 113 and 114:
Advisory C
Page 115 and 116:
Advisory C
Page 117 and 118:
Advisory C
show all

Advisory Committee on Pesticides Annual Report 2001

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?