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Advisory Committee on Pesticides Annual Report 2001

ACP Annual Report 2001 - Pesticides Safety Directorate

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<str<strong>on</strong>g>Advisory</str<strong>on</strong>g> <str<strong>on</strong>g>Committee</str<strong>on</strong>g> <strong>on</strong> <strong>Pesticides</strong> <strong>Annual</strong> <strong>Report</strong> <strong>2001</strong><br />

c) approval for the professi<strong>on</strong>al use of slow-release strips and c<strong>on</strong>trollable and<br />

n<strong>on</strong>-c<strong>on</strong>trollable cassettes c<strong>on</strong>taining dichlorvos in museums be retained<br />

subject to the fulfilment of physicochemical, operator exposure and efficacy<br />

data requirements;<br />

d) approval for the use of slow-release strips in pherom<strong>on</strong>e traps in areas<br />

where food may be stored, prepared or c<strong>on</strong>sumed be suspended pending<br />

the provisi<strong>on</strong> of informati<strong>on</strong> <strong>on</strong> food residues; and<br />

e) approval for the use of slow release strips in pherom<strong>on</strong>e traps in areas<br />

where food is not present be retained subject to the fulfilment of<br />

physicochemical and efficacy data requirements.<br />

A review of the agricultural uses of dichlorvos was also c<strong>on</strong>sidered by the<br />

ACP at the same time (see page 42).<br />

58<br />

The ACP also noted that dichlorvos was under discussi<strong>on</strong> by the <str<strong>on</strong>g>Committee</str<strong>on</strong>g><br />

<strong>on</strong> Mutagenicity of Chemicals in Food, C<strong>on</strong>sumer Products and the<br />

Envir<strong>on</strong>ment (CoM), and recognised that their recommendati<strong>on</strong>s would<br />

perhaps require modificati<strong>on</strong> in accordance with the COM’s findings.<br />

At the July <strong>2001</strong> ACP meeting, the <str<strong>on</strong>g>Committee</str<strong>on</strong>g> c<strong>on</strong>sidered the implicati<strong>on</strong>s of<br />

the COM’s possible c<strong>on</strong>clusi<strong>on</strong>s, and agreed to advise Ministers as follows:<br />

a) If the COM’s final c<strong>on</strong>clusi<strong>on</strong>s were that dichlorvos was an in-vivo<br />

mutagen, and it could not exclude the possibility that the occurrence<br />

of tumours in animal tests of carcinogenicity resulted from a genotoxic<br />

mechanism, there should be immediate revocati<strong>on</strong> of all uses (both<br />

agricultural and n<strong>on</strong>-agricultural).<br />

b) Alternatively, if the COM c<strong>on</strong>cluded that dichlorvos was an in-vivo<br />

mutagen, but that the tumours observed in animal tests did not result from<br />

a genotoxic mechanism, or if it could not c<strong>on</strong>firm that dichlorvos was an<br />

in-vivo mutagen, or if it took the view that dichlorvos was not an in-vivo<br />

mutagen, then the ACP’s previous recommendati<strong>on</strong>s would be maintained.<br />

The COM c<strong>on</strong>cluded, following a sec<strong>on</strong>d meeting in July <strong>2001</strong>, that dichlorvos<br />

should be regarded as an in-vivo mutagen (i.e. capable of inducing mutati<strong>on</strong>s<br />

in living animals) at site of c<strong>on</strong>tact and that it could not exclude the possibility<br />

of it acting as a genotoxic carcinogen. The COM statement <strong>on</strong> dichlorvos was<br />

finalised in late July <strong>2001</strong>.<br />

C<strong>on</strong>sequently the ACP recommended to Ministers that, as a precauti<strong>on</strong>ary<br />

measure, it would be prudent to revoke, with immediate effect, all agricultural

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