Advisory Committee on Pesticides Annual Report 2001

More documents

Recommendations

Info

Section B: Applications for provisional approvals for products containing new active substances proposed use. Therefore, no formal risk assessment for aquatic organisms was conducted. Spinosad is of low toxicity to other forms of wildlife (i.e. mammals, birds, earthworms and soil microbial processes). Given the low toxicity and limited exposure, the risk to these groups was considered sufficiently low not to warrant detailed assessment. The efficacy data submitted were considered sufficient to support the use of ‘Conserve’ to control western flower thrips in protected ornamentals. The <strong>Committee</strong> recommended that ‘Conserve’ should be granted a provisional approval for use on protected ornamentals under the Plant Protection Product Regulations, for three years pending the Commission decision on inclusion of spinosad in Annex I of Council Directive 91/414/EEC. The ACP highlighted a number of issues to be discussed as part of the European consideration. Sulfosulfuron Sulfosulfuron is a new sulfonylurea herbicide. The <strong>Committee</strong> considered an application for approval of the product ‘Monitor’, a water dispersible granule, for use on winter wheat to control certain grass and broad-leaved weeds. The active substance was also being considered for inclusion in Annex I of Directive 91/414/EEC with Ireland acting as Rapporteur Member State. 27 Sulfosulfuron and the formulated product are of low acute toxicity and are not classifiable on the grounds of human health effects. For both the acceptable daily intake (ADI) and systemic acceptable operator exposure level (AOEL), the toxic end point was the formation of calculi and associated lesions in the urinary bladder. An ADI of 0.24 mg/kg bw/day was agreed, based on a no observable adverse effect level (NOAEL) of 24 mg/kg bw/day observed in a two-year combined carcinogenicity/chronic feeding study in the rat and applying a 100-fold assessment factor. A systemic AOEL of 1.0 mg/kg bw/day was set, based on the NOAEL of 100 mg/kg bw/day observed in a 90-day dog study and a 100-fold assessment factor. A correction for oral absorption was not considered necessary for sulfosulfuron because absorption, distribution, metabolism and excretion (ADME) studies indicated a high extent of oral absorption. A dermal AOEL of 10 mg/kg bw/day was set based on the limit dose of 1000 mg/kg bw/day used in a 28-day dermal study in the rat (the study showed no effects related to treatment) and applying a 100-fold assessment factor. This was in line with the systemic AOEL (1.0 mg/kg bw/day) when the default dermal absorption value of ten percent was applied. A conservative estimate of operator exposure was two percent of the systemic AOEL.
<strong>Advisory</strong> <strong>Committee</strong> on Pesticides Annual Report 2001 Acceptable data were available on the nature and magnitude of residues that would result in wheat when sulfosulfuron was used in accordance with the principles of Good Agricultural Practice. Estimates of consumer dietary intakes were significantly lower than the ADI. The risks to birds, terrestrial vertebrates, bees, earthworms and soil microorganisms from the proposed use of sulfosulfuron and from metabolites formed in the environment were considered acceptable. The potential risk to aquatic higher plants is high. On the basis of its toxicity to Lemna gibba, ‘Monitor’ is classified as extremely dangerous to aquatic organisms. A five metre no spray zone was considered sufficient to manage the risk to aquatic higher plants from spray drift. 28 Sulfosulfuron might reach surface waters via drainflow. To address the potential risk to aquatic higher plants posed by parent compound as a consequence of drainflow, the applicant submitted modelling data for a number of scenarios covering five soil types and three climate types and using weather data for 30 years. These data indicated that only in a very few exceptional scenarios would the concentration of sulfosulfuron in surface water pose a risk to higher aquatic plants. The data on non-target plants provided indicated that there is a potential risk to plants close to the treated area. It was therefore recommended that the product label should carry a strong warning to avoid drift onto non-target plants. The <strong>Committee</strong> recommended provisional approval for ‘Monitor’ for use on winter wheat pending the Commission decision on inclusion of sulfosulfuron in Annex I of Council Directive 91/414/EEC. Zoxamide Zoxamide (Development code RH-7281) is the ISO proposed name for a new fungicide intended to control late blight on potato and downy mildew on grape. The <strong>Committee</strong> considered an application for approval of RH-7281 mancozeb, a water dispersible granule containing both zoxamide and mancozeb, a fungicidally active substance used in a number of products that are already approved for use in the UK. It was noted that the use of the two active substances in combination provided improved disease control over that achieved with mancozeb alone and allowed for a reduction in the rate of use for mancozeb. Zoxamide is also being considered for inclusion in Annex I of Directive 91/414/EEC with the UK acting as Rapporteur Member State.
Page 1 and 2: Department for Environment, Food an
Page 3 and 4: Department for Environment, Food an
Page 5 and 6: Advisory C
Page 35: Advisory C
Page 87 and 88:
Advisory C
Page 89 and 90:
Advisory C
Page 91 and 92:
Advisory C
Page 93 and 94:
Advisory C
Page 95 and 96:
Advisory C
Page 97 and 98:
Advisory C
Page 99 and 100:
Advisory C
Page 101 and 102:
Advisory C
Page 103 and 104:
Advisory C
Page 105 and 106:
Advisory C
Page 107 and 108:
Advisory C
Page 109 and 110:
Advisory C
Page 111 and 112:
Advisory C
Page 113 and 114:
Advisory C
Page 115 and 116:
Advisory C
Page 117 and 118:
Advisory C
show all

Advisory Committee on Pesticides Annual Report 2001

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?