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Internal-Medicine

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188 9: Muscles and Joints<br />

71. Most common form of eye involvement<br />

(SELECT ONE)<br />

72. Associated with increased frequency of infections<br />

(SELECT ONE)<br />

73. Found in association with occupational lung<br />

disease (SELECT ONE)<br />

74. Commonly involves Achillis tendon (SELECT<br />

ONE)<br />

DIRECTIONS (Questions 75 through 83): Each of<br />

the numbered items in this section is followed by<br />

answers. Select the ONE lettered answer that is<br />

BEST in each case.<br />

75. A 67-year-old woman develops symptoms of<br />

cough and sputum production after an upper<br />

respiratory tract infection. A CXR does not<br />

show any signs of pneumonia but the report<br />

mentions a “pseudofracture” sign (Looser<br />

zones) seen in the left scapula compatible with<br />

osteomalacia. She has no pain in the scapula.<br />

Which of the following best differentiates rickets<br />

and osteomalacia?<br />

(A)<br />

(B)<br />

(C)<br />

(D)<br />

(E)<br />

the mineralization defect is less severe<br />

in osteomalacia<br />

osteomalacia is only produced by vitamin<br />

D deficiency, unlike rickets<br />

the skeleton is at a different stage when<br />

affected<br />

parathyroid hormone levels are only<br />

routinely elevated in rickets<br />

rickets always is characterized by<br />

hypocalcemia<br />

76. A 72-year-old man is recently found to have<br />

hypocalcemia and osteomalacia is suspected<br />

based on the decrease in the cortical bone thickness<br />

and osteopenia is seen on x-rays. Which of<br />

the following is the most likely mechanism of<br />

the resistance to the effects of vitamin D?<br />

(A) excess parathyroid hormone secretion<br />

(B) insufficient parathyroid hormone<br />

secretion<br />

(C) defective receptors for 25(OH)<br />

vitamin D<br />

(D)<br />

(E)<br />

defective receptors for 1,25(OH)2<br />

vitamin D<br />

mineralocorticoid excess<br />

77. A 66-year-old woman complains of pain in her<br />

left hip when walking. Three days ago, she<br />

tripped and fell in her apartment. On examination,<br />

there is decreased range of motion in the<br />

hip, no leg length discrepancy. X-rays of the hip<br />

reveal osteopenia. Which of the following is the<br />

primary defect in vitamin D metabolism that<br />

causes osteopenia associated with aging?<br />

(A)<br />

(B)<br />

(C)<br />

(D)<br />

(E)<br />

impaired intestinal absorption of<br />

vitamin D<br />

impaired liver hydroxylation of<br />

vitamin D<br />

impaired renal hydroxylation of 1(OH)<br />

vitamin D<br />

low parathyroid hormone levels<br />

low phosphate levels<br />

78. Which of the following clinical findings is characteristic<br />

of both osteomalacia and rickets?<br />

(A)<br />

(B)<br />

(C)<br />

(D)<br />

(E)<br />

frontal bossing in the skull<br />

muscle weakness<br />

prominent costochondral junctions<br />

defects in tooth enamel<br />

knock-knees<br />

79. An 84-year-old man, previously well except for<br />

chronic osteoarthritis, develops a hot, red,<br />

painful knee. Physical examination reveals an<br />

exquisitely tender, swollen knee. Which of the<br />

following is the most likely finding on synovial<br />

fluid analysis?<br />

(A)<br />

(B)<br />

(C)<br />

(D)<br />

(E)<br />

staphylococcal infection<br />

gonococcal infection<br />

calcium hydroxyapatite crystals<br />

calcium pyrophosphate crystal deposition<br />

calcium oxalate<br />

80. A 74-year-old man has recurrent attacks of<br />

pain, swelling, and redness in his left knee. He<br />

has background osteoarthritis of both knees,<br />

which require him to take acetaminophen on a<br />

regular basis. Joint fluid was removed during<br />

one acute episode of knee pain, and synovial

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