Internal-Medicine

CHAPTER 11
Immunology and Allergy
Questions
DIRECTIONS (Questions 1 through 20): Each of
the numbered items in this section is followed by
answers. Select the ONE lettered answer that is
BEST in each case.
(C)
(D)
(E)
T lymphocytes, suppressor subset
B lymphocytes
granulocytes
1. A 29-year-old woman is being treated with
penicillin for “strep throat.” She develops
arthralgia, lymphadenopathy, urticaria, and an
active urine sediment 6 days after starting the
antibiotics. Which of the following is the most
likely mechanism of this drug reaction?
(A)
(B)
(C)
(D)
(E)
immunoglobulin E (IgE) release
mast cell degranulation
immediate-type hypersensitivity
macrophage-endothelial cell interaction
circulating immune complexes
2. A 24-year-old man is diagnosed with disseminated
histoplasmosis after developing symptoms
of fever, lymphadenopathy, hepatosplenomegaly,
and pancytopenia. Which of the following
is the body’s major immunologic defense against
histoplasmosis?
(A)
(B)
(C)
(D)
(E)
immunoglobulin G (IgG) antibodies
mononuclear leukocytes
complement
immunoglobulin M (IgM) antibody
neutrophils
3. Which of the following are large, granular lymphoid
cells that are mediators of antibodydependent
cellular cytotoxicity?
4. A 9-year-old boy presents with sneezing, runny
nose, and nasal congestion. The symptoms are
seasonal and worse in the spring time. He is
diagnosed with hay fever (allergic rhinitis).
Which of the following statements about hay
fever is correct?
(A) sufferers may develop asthma
(B) symptoms are not improved by moving
to different locations
(C) sufferers are less prone to develop
upper respiratory infections (URIs)
(D) sufferers are severely disturbed emotionally
(E) hay fever can be improved symptomatically
only with steroids
5. A 19-year-old man has recurrent attacks of gastrointestinal
colic and swelling of his face and
legs. There is no relationship of the attacks to
any foods or activity. His father has a similar
syndrome. Which of the following is the most
likely cause of death in this disease?
(A)
(B)
(C)
(D)
(E)
an unrelated condition
an anaphylactic shock reaction
edema of the glottis
overtreatment
a reaction
(A)
(B)
macrophages
natural killer (NK) cells
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