Internal-Medicine

50 2: Skin
50. (C) Chloroquine is used for certain skin diseases
such as lupus and polymorphous light
eruption, but can also cause skin reactions and
exacerbate porphyria cutanea tarda. Black pigmentation
can involve the face, mucous membrane,
and pretibial and subungual areas.
(Kasper, pp. 302, 322)
51. (D) Birth control pills, sulfonamides, and penicillins
are common drugs that can cause erythema
nodosum. This is a panniculitis
characterized by tender, subcutaneous, erythematous
nodules characteristically found on the
anterior portion of the legs. (Wolff, pp. 148–149)
is contraindicated in children under 8 years of
age because of the risk of discoloring permanent
teeth. (Kasper, p. 802)
53. (D, E) The combination of sulfamethoxazole and
trimethoprim causes two distinct cutaneous
reactions: an urticarial eruption in the first few
days of therapy and a morbilliform eruption
occurring a week or more after therapy has
begun. This latter reaction is particularly
common in patients with AIDS. Sulfonamides
cause numerous skin lesions, including erythema
nodosum. (Wolff, pp. 148–149)
52. (B) The only common skin reaction with tetracyclines
is photosensitivity. However, the drug